盐酸替洛隆
盐酸替洛隆结构式
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常用名 | 盐酸替洛隆 | 英文名 | Tilorone dihydrochloride |
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| CAS号 | 27591-69-1 | 分子量 | 483.471 | |
| 密度 | 1.102g/cm3 | 沸点 | 552.3ºC at 760 mmHg | |
| 分子式 | C25H36Cl2N2O3 | 熔点 | 230-233 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 287.8ºC | |
| 符号 |
GHS07, GHS08 |
信号词 | Warning |
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Development of sustained-release matrix tablets of BKP-01-041 (tilorone derivative) containing Hypromellose.
Pharmazie 68(10) , 796-9, (2013) The objective of this research was to develop and evaluate sustained-release matrix tablets of BKP-01-041 (tilorone derivative) based on Hypromellose (hydroxypropyl methylcellulose, HPMC) as the matrix forming polymer. The sustained-release tablets were prepa... |
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SAR of α7 nicotinic receptor agonists derived from tilorone: exploration of a novel nicotinic pharmacophore.
Bioorg. Med. Chem. Lett. 22 , 1633-8, (2012) The well-known interferon-inducer tilorone was found to possess potent affinity for the agonist site of the α7 neuronal nicotinic receptor (K(i)=56 nM). SAR investigations determined that both basic sidechains are essential for potent activity, however active... |
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Discovery of inhibitors of Bacillus anthracis primase DnaG.
Biochemistry 52(39) , 6905-10, (2013) Primase DnaG is an essential bacterial enzyme that synthesizes short ribonucleotide primers required for chromosomal DNA replication. Inhibitors of DnaG can serve as leads for development of new antibacterials and biochemical probes. We recently developed a n... |
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[Experimental and clinicolaboratory evaluation of complex therapy efficacy in arboviral infections].
Antibiot. Khimioter. 57(7-8) , 12-22, (2012) Search for drugs efficient in prophylaxis and treatment of dangerous infections (especially arboviral ones) is rather actual, since no specific therapy is available. Many-year investigations of interferon inductors showed that they had immunomodulating, antiv... |
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[Allergenic and immunotropic properties of yeast RNA-tilorone hydrochloride molecular complex].
Zh. Mikrobiol. Epidemiol. Immunobiol. (2) , 70-4, (2006) Immunotropic properties of the interferon-inducing molecular complex (MC) yeast RNA--tilorone hydrochloride have been under study. MC was experimentally studied in vivo to establish its influence on the amount of antibody-forming cells and the level of antibo... |
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[Antiviral effectiveness of the combined use of amixine and virasole in experimental hemorrhagic fever with renal syndrome in sucking albino mice].
Vopr. Virusol. 50(6) , 30-2, (2005) The antiviral effectiveness of the combined and single use of superlow-dose amixine and virasole on the course of experimental hemorrhagic fever with renal syndrome was studied in sucking albino mice parenterally infected with their virus Hantaan. The co-admi... |
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Small molecule activation of adaptive gene expression: tilorone or its analogs are novel potent activators of hypoxia inducible factor-1 that provide prophylaxis against stroke and spinal cord injury.
Ann. N. Y. Acad. Sci. 1147 , 383-94, (2008) A major challenge for neurological therapeutics is the development of small molecule drugs that can activate a panoply of downstream pathways without toxicity. Over the past decade our group has shown that a family of enzymes that regulate posttranscriptional... |
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alpha7 nicotinic acetylcholine receptor agonist properties of tilorone and related tricyclic analogues.
Br. J. Pharmacol. 153(5) , 1054-61, (2008) The alpha7 nicotinic acetylcholine receptor (nAChR) has attracted considerable interest as a target for cognitive enhancement in schizophrenia and Alzheimer's Disease. However, most recently described alpha7 agonists are derived from the quinuclidine structur... |
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DNA binding of tilorone: 1H NMR and calorimetric studies of the intercalation.
Biochemistry 46(27) , 8156-63, (2007) The fluorene derivative tilorone has received great attention as a DNA intercalator and has been widely recognized as an inducer of interferon. The biological activity of tilorone is known to be related to its binding mode with DNA; however, few structural an... |
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Chemically induced accumulation of GAGs delays PrP(Sc) clearance but prolongs prion disease incubation time.
Cell. Mol. Neurobiol. 28(7) , 1005-15, (2008) Prion diseases are a group of fatal neurodegenerative diseases affecting humans and animals. The only identified component of the infectious prion is PrP(Sc), an aberrantly folded isoform of PrP(C). Glycosaminoglycans, which constitute the main receptor for p... |