丁二酸酐
丁二酸酐结构式
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常用名 | 丁二酸酐 | 英文名 | Succinic anhydride |
|---|---|---|---|---|
| CAS号 | 108-30-5 | 分子量 | 100.073 | |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 261.0±0.0 °C at 760 mmHg | |
| 分子式 | C4H4O3 | 熔点 | 118-120 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 122.1±15.9 °C | |
| 符号 |
GHS05, GHS07, GHS08 |
信号词 | Danger |
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Synthesis of PS/PO-chimeric oligonucleotides using mixed oxathiaphospholane and phosphoramidite chemistry.
Org. Biomol. Chem. 13(1) , 269-76, (2014) Chimeric oligonucleotides containing phosphodiester and phosphorothioate linkages have been obtained using the solid phase synthesis. The oligonucleotide parts possessing natural internucleotide phosphate bonds were assembled using commercially available nucl... |
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Quantification of Sorafenib in Human Serum by Competitive Enzyme-Linked Immunosorbent Assay.
Biol. Pharm. Bull. 38 , 1788-93, (2015) The multikinase inhibitor sorafenib has been used in the treatment of hepatocellular carcinoma, renal cell carcinoma, and differentiated thyroid carcinoma. Here we have demonstrated the production of the first specific antibody against sorafenib. Anti-sorafen... |
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Iron Oxide and Titanium Dioxide Nanoparticle Effects on Plant Performance and Root Associated Microbes.
Int. J. Mol. Sci. 16 , 23630-50, (2015) In this study, we investigated the effect of positively and negatively charged Fe₃O₄ and TiO₂ nanoparticles (NPs) on the growth of soybean plants (Glycine max.) and their root associated soil microbes. Soybean plants were grown in a greenhouse for six weeks a... |
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Enhanced Antitumor Efficacy and Reduced Toxicity of Docetaxel Loaded Estradiol Functionalized Stealth Polymeric Nanoparticles.
Mol. Pharm. 12 , 3871-84, (2015) In spite of extensive research over the decades, breast cancer treatment is still a major challenge due to nonspecific distribution of the chemotherapeutics. This void can be filled by restricting the distribution of chemotherapeutics toward the cancerous cel... |
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Easy preparation of enantiomerically enriched heteroaromatic alcohols through lipase-catalyzed acylation with succinic anhydride under unconventional activation.
Bioprocess Biosyst. Eng. 38 , 1579-88, (2015) This study reports the lipase-catalyzed resolution of heteroaromatic secondary alcohols by succinic anhydride under different activation conditions by convenient procedure with succinic anhydride. The effects of succinic anhydride and the nature of the hetero... |
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Mass spectrometric evaluation of mephedrone in vivo human metabolism: identification of phase I and phase II metabolites, including a novel succinyl conjugate.
Drug Metab. Dispos. 43(2) , 248-57, (2014) In recent years, many new designer drugs have emerged, including the group of cathinone derivatives. One frequently occurring drug is mephedrone; although mephedrone was originally considered as a "legal high" product, it is currently banned in most Western c... |
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Swellable ciprofloxacin-loaded nano-in-micro hydrogel particles for local lung drug delivery.
AAPS PharmSciTech 15(6) , 1535-44, (2014) Incorporation of drug-loaded nanoparticles into swellable and respirable microparticles is a promising strategy to avoid rapid clearance from the lung and achieve sustained drug release. In this investigation, a copolymer of polyethylene glycol grafted onto p... |
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Somatostatin receptor-mediated specific delivery of paclitaxel prodrugs for efficient cancer therapy.
J. Pharm. Sci. 104 , 2018-28, (2015) In this study, a novel PTX prodrug, octreotide(Phe)-polyethene glycol-paclitaxel [OCT(Phe)-PEG-PTX], was successfully synthesized and used for targeted cancer therapy. A nontargeting conjugate, mPEG-PTX, was also synthesized and used as a control. Chemical st... |
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Stabilization of resveratrol in blood circulation by conjugation to mPEG and mPEG-PLA polymers: investigation of conjugate linker and polymer composition on stability, metabolism, antioxidant activity and pharmacokinetic profile.
PLoS ONE 10(3) , e0118824, (2015) Resveratrol is naturally occurring phytochemical with diverse biological activities such as chemoprevention, anti-inflammatory, anti-cancer, anti-oxidant. But undergoes rapid metabolism in the body (half life 0.13h). Hence Polymer conjugation utilizing differ... |
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Organic Radical Contrast Agents Based on Polyacetylenes Containing 2,2,6,6-Tetramethylpiperidine 1-Oxyl (TEMPO): Targeted Magnetic Resonance (MR)/Optical Bimodal Imaging of Folate Receptor Expressing HeLa Tumors in Vitro and in Vivo(a).
Macromol. Biosci. 15 , 788-98, (2015) Nitroxides have great potential as magnetic resonance imaging (MRI) contrast agents for tumor detection. Polyacetylenes(PAs) containing 2,2,6,6-tetramethyl-piperidine oxyl (TEMPO) and poly(ethylene glycol) were synthesized via metathesis polymerization of the... |