Histidine
Histidine结构式
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常用名 | Histidine | 英文名 | Histidine |
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| CAS号 | 6027-02-7 | 分子量 | 191.61500 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C6H10ClN3O2 | 熔点 | 287ºC (decomp) | |
| MSDS | 中文版 美版 | 闪点 | N/A |
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Highly specific in vivo gene delivery for p53-mediated apoptosis and genetic photodynamic therapies of tumour.
Nat. Commun. 6 , 6456, (2015) Anticancer therapies are often compromised by nonspecific effects and challenged by tumour environments' inherent physicochemical and biological characteristics. Often, therapeutic effect can be increased by addressing multiple parameters simultaneously. Here... |
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Histidine kinases and response regulators in networks.
Curr. Opin. Microbiol. 15(2) , 118-24, (2011) Two-component systems, composed of a histidine kinase (HK) and a response regulator (RR), are the major signal transduction devices in bacteria. Originally it was thought that these two components function as linear, phosphorylation-driven stimulus-response s... |
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Assessing the fractions of tautomeric forms of the imidazole ring of histidine in proteins as a function of pH.
Proc. Natl. Acad. Sci. U. S. A. 108 , 5602-5607, (2011) A method is proposed to determine the fraction of the tautomeric forms of the imidazole ring of histidine in proteins as a function of pH, provided that the observed and chemical shifts and the protein structure, or the fraction of H(+) form, are known. This ... |
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Could carnosine or related structures suppress Alzheimer's disease?
J. Alzheimers Dis. 11 , 229-240, (2007) Reactive oxygen species, reactive nitrogen species, copper and zinc ions, glycating agents and reactive aldehydes, protein cross-linking and proteolytic dysfunction may all contribute to Alzheimer's disease (AD). Carnosine (beta-alanyl-L-histidine) is a natur... |
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Influence of amino acid relative position on the oxidative modification of histidine and glycine peptides.
Anal. Bioanal. Chem 399 , 2779-2794, (2011) The radical oxidation of isomeric peptides containing one reactive amino acid [histidine (H)] and another less reactive amino acid [glycine (G)] in the form of dipeptides (HG and GH) and tripeptides (HGG, GHG, and GGH) was studied by mass spectrometry coupled... |
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Histidine-rich glycoprotein: a possible modulator of coagulation and fibrinolysis.
Semin. Thromb. Hemost. 37 , 389-394, (2011) Histidine-rich glycoprotein (HRG) is one of the major plasma proteins and thought to function in blood coagulation, fibrinolysis, and innate immune systems. The amino acid sequence of HRG revealed a multidomain structure consisting of cystatin-like domains 1 ... |
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Conformationally constrained histidines in the design of peptidomimetics: strategies for the χ-space control.
Int. J. Mol. Sci. 12 , 2853-2890, (2011) A successful design of peptidomimetics must come to terms with χ-space control. The incorporation of χ-space constrained amino acids into bioactive peptides renders the χ(1) and χ(2) torsional angles of pharmacophore amino acids critical for activity and sele... |
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Effects of histidine and n-acetylcysteine on experimental lesions induced by doxorubicin in sciatic nerve of rats.
Drug Chem. Toxicol. 38 , 436-41, (2015) In this study, the effect of separate and combined intraperitoneal (i.p.) injections of histidine and n-acetylcysteine were investigated on experimental damage induced by doxorubicin (DOX) in sciatic nerve of rats. DOX was i.p. injected at a dose of 4 mg/kg o... |
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Oral administration of vitamin C and histidine attenuate cyclophosphamide-induced hemorrhagic cystitis in rats.
Indian J. Pharmacol. 45 , 126-9, (2013) Cyclophosphamide (CP), a widely used antineoplastic drug causes hemorrhagic cystitis (HC) mainly via induction of oxidative stress. Both vitamin C and histidine have antioxidant properties. The present study aimed to investigate the effects of oral (p.o.) adm... |
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Reprint of: Immobilized-Metal Affinity Chromatography (IMAC): A Review. Block H, Maertens B, Spriestersbach A, et al.
Protein Expr. Purif. , DOI: 10.1016/j.pep.2011.08.021,, (2011)
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