2-([1,1-联苯]-4-基氨基甲酰)苯甲酸
![2-([1,1-联苯]-4-基氨基甲酰)苯甲酸结构式](https://image.chemsrc.com/caspic/271/4727-31-5.png)
2-([1,1-联苯]-4-基氨基甲酰)苯甲酸结构式
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常用名 | 2-([1,1-联苯]-4-基氨基甲酰)苯甲酸 | 英文名 | Kartogenin |
|---|---|---|---|---|
| CAS号 | 4727-31-5 | 分子量 | 317.338 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 464.4±38.0 °C at 760 mmHg | |
| 分子式 | C20H15NO3 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 234.6±26.8 °C | |
| 符号 |
GHS07, GHS09 |
信号词 | Warning |
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Hyaluronic acid prevents immunosuppressive drug-induced ovarian damage via up-regulating PGRMC1 expression.
Sci. Rep. 5 , 7647, (2015) Chemotherapy treatment in women can frequently cause damage to the ovaries, which may lead to primary ovarian insufficiency (POI). In this study, we assessed the preventative effects of hyaluronic acid (HA) in immunosuppressive drug-induced POI-like rat model... |
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Impaired development of female mouse offspring maternally exposed to simazine.
Environ. Toxicol. Pharmacol. 38(3) , 845-51, (2014) Simazine is a suspected endocrine disruptor and the second most commonly detected pesticide in surface and groundwater worldwide. We evaluated the toxicity of simazine in female mouse offspring with in utero and lactational exposure to the agent. Pregnant mic... |
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Full-thickness cartilage defects are repaired via a microfracture technique and intraarticular injection of the small-molecule compound kartogenin.
Arthritis. Res. Ther. 17 , 20, (2015) Microfracture does not properly repair full-thickness cartilage defects. The purpose of this study was to evaluate the effect of intraarticular injection of the small-molecule compound kartogenin (KGN) on the restoration of a full-thickness cartilage defect t... |
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Mouse GDF9 decreases KITL gene expression in human granulosa cells.
Endocrine 48(2) , 686-95, (2015) Kit ligand (KITL) is an important granulosa cell-derived growth factor in ovarian folliculogenesis, but its expression and function in human granulosa cells are currently poorly understood. Based on studies performed in animal models, it was hypothesised that... |
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Kartogenin, transforming growth factor-β1 and bone morphogenetic protein-7 coordinately enhance lubricin accumulation in bone-derived mesenchymal stem cells.
Cell Biol. Int. 39 , 1026-35, (2015) Osteoarthritis, a common joint degeneration, can cause breakdown of articular cartilage with the presence of lubricin metabolic abnormalities. Lubricin is a multi-level chondroprotective mucinous glycoprotein in articular joints. Joint defect and infection is... |
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Tyrosine Kinase Inhibitors as Potential Therapeutic Agents in the Treatment of Granulosa Cell Tumors of the Ovary.
Int. J. Gynecol. Cancer 25 , 1224-31, (2015) Granulosa cell tumors of the ovary (GCTs) represent a specific subset of malignant ovarian tumors, of which there are 2 distinct subtypes, the juvenile and the adult form. Aside from surgery, no reliable therapeutic options currently exist for patients with G... |
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Frataxin inactivation leads to steroid deficiency in flies and human ovarian cells.
Hum. Mol. Genet. 24 , 2615-26, (2015) Friedreich ataxia (FA), the most common inherited autosomal-recessive ataxia in Caucasians, is characterized by progressive degeneration of the central and peripheral nervous system, hypertrophic cardiomyopathy and increased incidence of diabetes. FA is cause... |
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FOXL2 Is an Essential Activator of SF-1-Induced Transcriptional Regulation of Anti-Müllerian Hormone in Human Granulosa Cells.
PLoS ONE 11 , e0159112, (2016) Anti-Müllerian hormone (AMH) is required for proper sexual differentiation by regulating the regression of the Müllerian ducts in males. Recent studies indicate that AMH could be an important factor for maintaining the ovarian reserve. However, the mechanisms... |
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Creating an Animal Model of Tendinopathy by Inducing Chondrogenic Differentiation with Kartogenin.
PLoS ONE 11 , e0148557, (2016) Previous animal studies have shown that long term rat treadmill running induces over-use tendinopathy, which manifests as proteoglycan accumulation and chondrocytes-like cells within the affected tendons. Creating this animal model of tendinopathy by long ter... |