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4-[6-[4-异丙氧基苯基]吡唑并[1,5-a]嘧啶-3-基]喹啉

4-[6-[4-异丙氧基苯基]吡唑并[1,5-a]嘧啶-3-基]喹啉结构式
4-[6-[4-异丙氧基苯基]吡唑并[1,5-a]嘧啶-3-基]喹啉结构式
品牌特惠专场
常用名 4-[6-[4-异丙氧基苯基]吡唑并[1,5-a]嘧啶-3-基]喹啉 英文名 DMH-1
CAS号 1206711-16-1 分子量 380.442
密度 1.2±0.1 g/cm3 沸点 N/A
分子式 C24H20N4O 熔点 N/A
MSDS 中文版 美版 闪点 N/A
符号 GHS06
GHS06
信号词 Danger

Spinal muscular atrophy patient-derived motor neurons exhibit hyperexcitability.

Sci. Rep. 5 , 12189, (2015)

Spinal muscular atrophy (SMA) presents severe muscle weakness with limited motor neuron (MN) loss at an early stage, suggesting potential functional alterations in MNs that contribute to SMA symptom presentation. Using SMA induced pluripotent stem cells (iPSC...

Derivation of mesenchymal stromal cells from pluripotent stem cells through a neural crest lineage using small molecule compounds with defined media.

PLoS ONE 9(12) , e112291, (2014)

Neural crest cells (NCCs) are an embryonic migratory cell population with the ability to differentiate into a wide variety of cell types that contribute to the craniofacial skeleton, cornea, peripheral nervous system, and skin pigmentation. This ability sugge...

The BMP Pathway Participates in Human Naive CD4+ T Cell Activation and Homeostasis.

PLoS ONE 10 , e0131453, (2015)

Bone Morphogenetic Proteins (BMPs) form a group of secreted factors that belongs to the TGF-β superfamily. Among different roles in a number of immune cell types, BMPs are known to regulate T cell development within the thymus, although the role of BMP signal...

Bone morphogenetic protein 2 promotes primordial follicle formation in the ovary.

Sci. Rep. 5 , 12664, (2015)

Primordial follicles (PF) are formed when somatic cells differentiate into flattened pregranulosa cells, invaginate into the oocyte nests and encircle individual oocytes. We hypothesize that BMP2 regulates PF formation by promoting the transition of germ cell...

(4-[6-(4-isopropoxyphenyl)pyrazolo [1,5-a]pyrimidin-3-yl] quinoline) is a novel inhibitor of autophagy.

Br. J. Pharmacol. 171(21) , 4970-80, (2014)

Autophagy is an important intracellular degradation system, which is related to various diseases. In preliminary experiments we found that D4-[6-(4-isopropoxyphenyl)pyrazolo [1,5-a]pyrimidin-3-yl] quinoline (DMH1) inhibited autophagy responses. However DMH1 a...

Discovery and mapping of Brassica juncea Sdt 1 gene associated with determinate plant growth habit.

Theor. Appl. Genet. 128(2) , 235-45, (2015)

Newly discovered determinate plant growth habit in Brassica juncea is simply inherited and can help in architectural restructuring of Brassica oilseeds. Brassica juncea is naturally indeterminate. This growth habit tends to accentuate intra-plant competition ...

Optimal effector functions in human natural killer cells rely upon autocrine bone morphogenetic protein signaling.

Cancer Res. 74(18) , 5019-31, (2014)

Natural killer (NK) cells are critical for innate tumor immunity due to their specialized ability to recognize and kill neoplastically transformed cells. However, NK cells require a specific set of cytokine-mediated signals to achieve optimal effector functio...

Commercially Available Preparations of Recombinant Wnt3a Contain Non-Wnt Related Activities Which May Activate TGF-β Signaling.

J. Cell. Biochem. 117 , 938-45, (2016)

The Wnt ligands are a family of secreted signaling proteins which play key roles in a number of cellular processes under physiological and pathological conditions. Wnts bind to their membrane receptors and initiate a signaling cascade which leads to the nucle...

The zebrafish tailbud contains two independent populations of midline progenitor cells that maintain long-term germ layer plasticity and differentiate in response to local signaling cues.

Development 143 , 244-54, (2016)

Vertebrate body axis formation depends on a population of bipotential neuromesodermal cells along the posterior wall of the tailbud that make a germ layer decision after gastrulation to form spinal cord and mesoderm. Despite exhibiting germ layer plasticity, ...