芦平曲韦
芦平曲韦结构式
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常用名 | 芦平曲韦 | 英文名 | Rupintrivir |
|---|---|---|---|---|
| CAS号 | 223537-30-2 | 分子量 | 598.66200 | |
| 密度 | 1.213g/cm3 | 沸点 | 866.7ºC at 760mmHg | |
| 分子式 | C31H39FN4O7 | 熔点 | 170-171°C | |
| MSDS | 美版 | 闪点 | 477.9ºC |
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Crystal structures of enterovirus 71 3C protease complexed with rupintrivir reveal the roles of catalytically important residues.
J. Virol. 85(19) , 10021-30, (2011) EV71 is the primary pathogenic cause of hand-foot-mouth disease (HFMD), but an effective antiviral drug currently is unavailable. Rupintrivir, an inhibitor against human rhinovirus (HRV), has potent antiviral activities against EV71. We determined the high-re... |
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Conservation of amino acids in human rhinovirus 3C protease correlates with broad-spectrum antiviral activity of rupintrivir, a novel human rhinovirus 3C protease inhibitor.
Antimicrob. Agents Chemother. 49(2) , 619-26, (2005) The picornavirus 3C protease is required for the majority of proteolytic cleavages that occur during the viral life cycle. Comparisons of published amino acid sequences from 6 human rhinoviruses (HRV) and 20 human enteroviruses (HEV) show considerable variabi... |
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