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澳洲茄边碱

更新时间:2025-12-28 17:52:01 采购访问:16次

常用名 澳洲茄边碱 CAS号 20311-51-7
价格 纯度 98.0%
备货期 10天 库存 现货
 产品详情(用途,包装等)
用途:
Solamargine is a major steroidal alkaloid glycoside extracted from a traditional Chinese medicinal herb, Solanum nigrum L. (SNL); has been shown to inhibit growth and induce apoptosis of various cancer cells. IC50 value:Target: Anticancer natural compoundin vitro: Solamargine reduced HepG2 cell viability in a concentration-dependent manner. At 7.5μM solamargine decreased cell viability by less than 20% in HepG2 cells. At the highest dose, solamargine decreased cell migration and invasion by more than 70% and 72% in HepG2 cells, respectively. Western blotting and gelatin zymography results showed that solamargine reduced expression and function of MMP-2 and MMP-9 proteins [1]. SM increased phosphorylation of p38 mitogen-activated protein kinase (p38 MAPK) in a time-dependent fashion. SM also inhibited phosphorylation and protein expression of signal transducer and activator of transcription 3 (Stat3), a transcription factor, which was abrogated by the SB203580, a specific inhibitor of p38 MAPK. In addition, SM induced protein expression of p21, one of cyclin-dependent kinase inhibitors, and this was not observed in cell overexpression of Stat3 or cells treated with SB203580 [2]. SM significantly inhibited the growth of SMMC-7721 and HepG2 cells and induced cell apoptosis. Cell cycle analysis revealed that SM caused cell cycle arrest at the G2/M phase. Moreover, SM could up-regulate the expression of caspase-3 [3].
物理化学性质:
CAS号:20311-51-7
常用中文名:澳洲茄边碱
常用英文名:Solamargine
分子式:C45H73NO15
分子量:868.059
密度:1.4±0.1 g/cm3
沸点:N/A
熔点:N/A
闪点:N/A
储存条件:-20°C

供应商信息

上海念兴实业有限公司 认证供应商

认证状态:已认证供应商
商品数:403768件
电话:18916513247
地址:2222 Huancheng Road, Juyuan New District, Jiading District, Shanghai
地区: 上海市 上海市 普陀区
联系人:小陈
联系人电话:0086-021-52280163
邮件:sales@echemcloud.com
网址:http://www.echemcloud.com
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参考价格:$206/10mM*1mLinDMSO
其他供应商价格:
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价格:¥350.0
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价格:¥2489.0
2024-05-08 澳洲茄边碱
价格:¥需询单

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