<生产厂家价格>

奥昔卡因

奥昔卡因用途

Oxethazaine是一种局部麻醉剂,在防止酸诱导的食管疼痛。

奥昔卡因名称

[ CAS 号 ]:
126-27-2

[ 中文名 ]:
奥昔卡因

[ 英文名 ]:
Oxethazaine

[中文别名 ]:

阿塞赛因

[英文别名 ]:

EINECS 204-780-5
MFCD00079202
oxethazine

奥昔卡因生物活性

[ 描述 ]:

Oxethazaine是一种局部麻醉剂,在防止酸诱导的食管疼痛。

[ 相关类别 ]:

信号通路 >> 抗感染 >> HBV

研究领域 >> 神经疾病

[相关活性小分子]

奥昔卡因物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
630.4±55.0 °C at 760 mmHg

[ 熔点 ]:
104-105°C

[ 分子式 ]:
C₂₈H₄₁N₃O₃

[ 分子量 ]:
467.643

[ 闪点 ]:
335.1±31.5 °C

[ 精确质量 ]:
467.314789

[ PSA ]:
64.09000

[ LogP ]:
4.94

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
0.0±1.9 mmHg at 25°C

[ 折射率 ]:
1.558

[ 储存条件 ]:
2-8℃

[ 水溶解性 ]:
<0.1 g/100 mL at 23 ºC

奥昔卡因MSDS

奥昔卡因毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AC3325000

CHEMICAL NAME :: Acetamide, 2,2'-((2-hydroxyethyl)imino)bis(N-(alpha,alpha-dimeth ylphenethyl)-N-methyl-

CAS REGISTRY NUMBER :: 126-27-2

BEILSTEIN REFERENCE NO. :: 2404063

LAST UPDATED :: 199806

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C28-H41-N3-O3

MOLECULAR WEIGHT :: 467.72

WISWESSER LINE NOTATION :: R1X1&1&N1&V1N2Q1VN1&X1&1&1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 30 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 27 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 58 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TEST SYSTEM :: Mold - Aspergillus nidulans

DOSE/DURATION :: 1 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 26,159,1974 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82267 No. of Facilities: 838 (estimated) No. of Industries: 2 No. of Occupations: 5 No. of Employees: 29119 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82267 No. of Facilities: 32 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1056 (estimated) No. of Female Employees: 490 (estimated)

奥昔卡因安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
AC3325000

奥昔卡因合成路线

奥昔卡因上下游产品

奥昔卡因上游产品

奥昔卡因下游产品

奥昔卡因文献

Oxethazaine as the source of mephentermine and phentermine in athlete's urine

Forensic Sci. Int. 185(1-3) , e1-5, (2009)

The urine specimens of numerous athletes were found to be positive for mephentermine both in-competition and out-of-competition in Taiwan. The donor of one specimen claimed she had only taken Mucaine ...

Confirming urinary excretion of mephentermine and phentermine following the ingestion of oxethazaine by gas chromatography-mass spectrometry analysis.

J. Anal. Toxicol. 34(2) , 73-7, (2010)

Mephentermine and phentermine, substances prohibited in sports by the World Anti-Doping Agency, were found for the first time in urine specimens following the administration of a therapeutic medicatio...

A double-blind controlled study to compare the efficacy of an antacid plus oxethazaine with that of an antacid alone in the treatment of pain due to gastric or duodenal ulceration.

Curr. Med. Res. Opin. 10(2) , 128-34, (1986)

A double-blind study was carried out in 40 patients with typical ulcer pain and suffering from gastric or duodenal ulcer to compare the pain-relieving efficacy of oxethazaine/magnesium and aluminium h...

更多文献