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阿地砜钠

阿地砜钠用途

磺胺酮二钠是一种口服活性磺胺类抗生素,用于治疗麻风病。磺胺酮二钠也可用于疱疹样皮炎的研究[1][2]。

阿地砜钠名称

[ CAS 号 ]:
144-75-2

[ 中文名 ]:
阿地砜钠

[ 英文名 ]:
Aldesulfone Sodium

[中文别名 ]:

阿地砜

[英文别名 ]:

Sodium sulfoxone
Aldapsone
Diazon
Adesulfone sodium
Diamidin
Novotrone
Aldesulfone [Sodium]
SULFOXONE SODIUM
Diasone

阿地砜钠生物活性

[ 描述 ]:

磺胺酮二钠是一种口服活性磺胺类抗生素,用于治疗麻风病。磺胺酮二钠也可用于疱疹样皮炎的研究[1][2]。

[ 相关类别 ]:

研究领域 >> 感染

研究领域 >> 炎症/免疫

信号通路 >> 抗感染 >> 细菌

阿地砜钠物理化学性质

[ 沸点 ]:
857.3ºC at 760 mmHg

[ 分子式 ]:
C₁₄H₁₄N₂Na₂O₆S₃

[ 分子量 ]:
448.44500

[ 闪点 ]:
472.3ºC

[ 精确质量 ]:
447.98100

[ PSA ]:
185.26000

[ LogP ]:
3.97460

[ 蒸汽压 ]:
2.64E-31mmHg at 25°C

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.

阿地砜钠毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: PB0390100

CHEMICAL NAME :: Methanesulfinic acid, (sulfonylbis(p-phenyleneimino))di-, disodium salt

CAS REGISTRY NUMBER :: 144-75-2

LAST UPDATED :: 199606

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C14-H14-N2-O6-S3.2Na

MOLECULAR WEIGHT :: 448.46

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >7 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JLCMAK Journal of Laboratory and Clinical Medicine. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1915- Volume(issue)/page/year: 30,317,1945

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JACSAT Journal of the American Chemical Society. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1879- Volume(issue)/page/year: 70,1268,1948

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JACSAT Journal of the American Chemical Society. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1879- Volume(issue)/page/year: 61,617,1939

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JLCMAK Journal of Laboratory and Clinical Medicine. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1915- Volume(issue)/page/year: 30,317,1945

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JLCMAK Journal of Laboratory and Clinical Medicine. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1915- Volume(issue)/page/year: 30,317,1945 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 18900 mg/kg/21D-C

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Related to Chronic Data - death

REFERENCE :: JLCMAK Journal of Laboratory and Clinical Medicine. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1915- Volume(issue)/page/year: 30,317,1945

阿地砜钠安全信息

[ 海关编码 ]:
2930909090

阿地砜钠海关

[ 海关编码 ]: 2930909090

[ 中文概述 ]:
2930909090. 其他有机硫化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%