144-75-2

• 常用中文名：阿地砜钠
• 常用英文名：Aldesulfone Sodium
• CAS号：144-75-2
• 分子式：C₁₄H₁₄N₂Na₂O₆S₃
• 分子量：448.44500
• 相关类别： 原料药 人工合成抗感染类药 抗结核麻风分支杆菌类药
• 发布时间：2018-07-10 20:57:42
• 更新时间：2024-01-02 08:56:59
• 磺胺酮二钠是一种口服活性磺胺类抗生素,用于治疗麻风病。磺胺酮二钠也可用于疱疹样皮炎的研究[1][2]。

名称

• 中文名: 阿地砜钠
• 英文名: disodium,[4-[4-(sulfinatomethylamino)phenyl]sulfonylanilino]methanesulfinate
• 中文别名: 阿地砜
• 英文别名: Sodium sulfoxone; Aldapsone; Diazon; (4,4'-sulfonyl-dianilino)-bis-methanesulfinic acid,disodium-salt; Adesulfone sodium; (4,4'-Sulfonyl-dianilino)-bis-methansulfinsaeure,Dinatrium-Salz; Diamidin; Novotrone; Aldesulfone [Sodium]; SULFOXONE SODIUM; Diasone

物化性质

• 沸点: 857.3ºC at 760 mmHg
• 分子式: C₁₄H₁₄N₂Na₂O₆S₃
• 分子量: 448.44500
• 闪点: 472.3ºC
• 精确质量: 447.98100
• PSA: 185.26000
• LogP: 3.97460
• 蒸汽压: 2.64E-31mmHg at 25°C
• 稳定性: Stable. Incompatible with strong oxidizing agents.
• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:2

  3.氢键受体数量:10

  4.可旋转化学键数量:6

  5.互变异构体数量:无

  6.拓扑分子极性表面积185

  7.重原子数量:27

  8.表面电荷:0

  9.复杂度:509

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:3

生物活性

• 描述: 磺胺酮二钠是一种口服活性磺胺类抗生素,用于治疗麻风病。磺胺酮二钠也可用于疱疹样皮炎的研究[1][2]。
• 相关类别:
  研究领域 >> 感染
  研究领域 >> 炎症/免疫
  信号通路 >> 抗感染 >> 细菌

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : PB0390100 CHEMICAL NAME : Methanesulfinic acid, (sulfonylbis(p-phenyleneimino))di-, disodium salt CAS REGISTRY NUMBER : 144-75-2 LAST UPDATED : 199606 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C14-H14-N2-O6-S3.2Na MOLECULAR WEIGHT : 448.46 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >7 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JLCMAK Journal of Laboratory and Clinical Medicine. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1915- Volume(issue)/page/year: 30,317,1945 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 10 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JACSAT Journal of the American Chemical Society. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1879- Volume(issue)/page/year: 70,1268,1948 TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >3 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JACSAT Journal of the American Chemical Society. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1879- Volume(issue)/page/year: 61,617,1939 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 3 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JLCMAK Journal of Laboratory and Clinical Medicine. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1915- Volume(issue)/page/year: 30,317,1945 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 1500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JLCMAK Journal of Laboratory and Clinical Medicine. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1915- Volume(issue)/page/year: 30,317,1945 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 18900 mg/kg/21D-C TOXIC EFFECTS : Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Related to Chronic Data - death REFERENCE : JLCMAK Journal of Laboratory and Clinical Medicine. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1915- Volume(issue)/page/year: 30,317,1945

安全

• 海关编码: 2930909090

海关

海关编码	2930909090
中文概述	2930909090. 其他有机硫化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途
Summary	2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%