抗痛素二盐酸盐

抗痛素二盐酸盐用途

Antipain dihydrochloride是一种从 Actinomycetes 分离的蛋白酶 (protease) 抑制剂。Antipain dihydrochloride 抑制 N-甲基-N'-硝基-N-亚硝基胍 (MNNG) 诱导的转化,增加染色体畸变。Antipain dihydrochloride 限制小鼠中子宫 DNA 合成和功能。

抗痛素二盐酸盐名称

[ CAS 号 ]:
37682-72-7

[ 中文名 ]:
抗痛素二盐酸盐

[ 英文名 ]:
BDBM32804

[中文别名 ]:

[英文别名 ]:

MFCD00135957
antipain, dihydrochloride
Antipain

抗痛素二盐酸盐生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> Ser/Thr蛋白酶

研究领域 >> 癌症

信号通路 >> 细胞周期/DNA损伤 >> DNA/RNA合成

研究领域 >> 代谢疾病

[体内研究]

完整的,骑自行车的雌性小鼠接受皮下注射盐酸安替品(3毫克)16天,与未经治疗的对照组相比,它们的子宫重量和总DNA明显减少[4]。盐酸安替品(100μg/g体重；i.p.；间隔12h,0~120h或240~360h)对乌拉坦诱发的小鼠肺肿瘤有抑制作用[5]。

[参考文献]

[1]. DiPaolo JA, et al. Antipain inhibits N-methyl-N'-nitro-N-nitrosoguanidine-induced transformation and increases chromosomal aberrations. Proc Natl Acad Sci U S A. 1980 Nov;77(11):6649-53.

[2]. Suda H,et al. Antipain, a new protease inhibitor isolated from actinomycetes. J Antibiot (Tokyo). 1972 Apr;25(4):263-6.

[3]. Sudha VT, et al. Identification of a serine protease as a major allergen (Per a 10) of Periplaneta americana. Allergy. 2008 Jun;63(6):768-76.

[4]. Nomura T, et al. Inhibiting effects of antipain on urethane-induced lung neoplasia in mice. Br J Cancer. 1980;42(4):624‐626.

[5]. Katz J, et al. Antipain and leupeptin restrict uterine DNA synthesis and function in mice. Proc Natl Acad Sci U S A. 1977;74(9):3754‐3757.

抗痛素二盐酸盐物理化学性质

[ 分子式 ]:
C₂₇H₄₆Cl₂N₁₀O₆

[ 分子量 ]:
677.623

[ 精确质量 ]:
676.297913

[ PSA ]:
277.50000

[ LogP ]:
4.25060

[ 外观性状 ]:
白色至灰白色粉末

[ 储存条件 ]:
20°C

抗痛素二盐酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YV9350800

CHEMICAL NAME :: L-Valinamide, N(sup 2)-(((1-carboxy-2-phenylethyl)amino)carbonyl)-L-argin yl-N-(4-((amino iminomethyl)amino)-1-formylbutyl)-, dihydrochloride

CAS REGISTRY NUMBER :: 37682-72-7

LAST UPDATED :: 199206

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C27-H44-N10-O6.2Cl-H

MOLECULAR WEIGHT :: 677.73

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 25,263,1972

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 25,263,1972

抗痛素二盐酸盐安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
22-24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
YV9350800

抗痛素二盐酸盐文献

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Preparation of extracts from plants.

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