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氰戊菊酯

氰戊菊酯用途

Fenvalerate 是一种有效的蛋白磷酸酶 2B (钙调神经磷酸酶；calcineurin) 抑制剂,对 PP2B-Aα 的IC50 为 2-4 nM。Fenvalerate 是拟除虫菊酯杀虫剂和杀螨剂。

氰戊菊酯名称

[ CAS 号 ]:
51630-58-1

[ 中文名 ]:
氰戊菊酯

[ 英文名 ]:
fenvalerate

[中文别名 ]:

[英文别名 ]:

Phenvalerate
fenvalerate
Pydrin
Belmark
Tirade
MFCD00055324
Sumicidin
EINECS 257-326-3

氰戊菊酯生物活性

[ 描述 ]:

Fenvalerate 是一种有效的蛋白磷酸酶 2B (钙调神经磷酸酶；calcineurin) 抑制剂,对 PP2B-Aα 的IC50 为 2-4 nM。Fenvalerate 是拟除虫菊酯杀虫剂和杀螨剂。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 磷酸酶

研究领域 >> 感染

信号通路 >> 抗感染 >> 细菌

[体外研究]

氰戊菊酯对PP2B-Bβ无活性[1]。

[参考文献]

[1]. E Enan, et al. Specific Inhibition of Calcineurin by Type II Synthetic Pyrethroid Insecticides. Biochem Pharmacol. 1992 Apr 15;43(8):1777-84.

[2]. A R Reilein, et al. Regulation of Organelle Movement in Melanophores by Protein Kinase A (PKA), Protein Kinase C (PKC), and Protein Phosphatase 2A (PP2A). J Cell Biol. 1998 Aug 10;142(3):803-13.

氰戊菊酯物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
538.9±50.0 °C at 760 mmHg

[ 分子式 ]:
C₂₅H₂₂ClNO₃

[ 分子量 ]:
419.900

[ 闪点 ]:
279.7±30.1 °C

[ 精确质量 ]:
419.128815

[ PSA ]:
59.32000

[ LogP ]:
6.68

[ 外观性状 ]:
一种透明恶性黄色液体

[ 蒸汽压 ]:
0.0±1.4 mmHg at 25°C

[ 折射率 ]:
1.586

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运

氰戊菊酯MSDS

详细MSDS(安全技术说明书)

氰戊菊酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CY1576350

CHEMICAL NAME :: Benzeneacetic acid, 4-chloro-alpha-(1-methylethyl)-, cyano(3-phenoxyphenyl)methyl ester

CAS REGISTRY NUMBER :: 51630-58-1

LAST UPDATED :: 199801

DATA ITEMS CITED :: 43

MOLECULAR FORMULA :: C25-H22-Cl-N-O3

MOLECULAR WEIGHT :: 419.93

WISWESSER LINE NOTATION :: 1Y1&YR DG&VOYCN&R COR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 70200 ug/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Behavioral - excitement Behavioral - ataxia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - changes in motor activity (specific assay) Behavioral - muscle contraction or spasticity

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 202 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 185 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intracerebral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 2400 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Gastrointestinal - hypermotility, diarrhea Gastrointestinal - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: >4 gm/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - muscle weakness Behavioral - muscle contraction or spasticity

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - domestic

DOSE/DURATION :: >1600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 451 mg/kg

TOXIC EFFECTS :: Brain and Coverings - recordings from specific areas of CNS

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 36400 mg/kg/2Y-C

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2002 mg/kg/13W-C

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 290 ug/m3/24H/13W-C

TOXIC EFFECTS :: Blood - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - catalases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 109 gm/kg/2Y-C

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in bladder weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 4550 mg/kg/26W-I

TOXIC EFFECTS :: Blood - changes in cell count (unspecified) Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 14717 mg/kg/28D-I

TOXIC EFFECTS :: Blood - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: 180 gm/kg/5D-C

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: 1152 mg/kg/7D-C

TOXIC EFFECTS :: Gastrointestinal - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Parenteral

DOSE :: 100 mg/kg

SEX/DURATION :: male 5 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

TYPE OF TEST :: Morphological transformation

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Sperm Morphology

TYPE OF TEST :: Sperm Morphology

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Rodent - rabbit Cells - not otherwise specified

DOSE/DURATION :: 200 ug/L

REFERENCE :: JPFCD2 Journal of Environmental Science and Health, Part B: Pesticides, Food Contaminants, and Agricultural Wastes. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.B11- 1976- Volume(issue)/page/year: 23,439,1988 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 53,309,1991 IARC Cancer Review:Human No Available Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 53,309,1991 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 53,309,1991 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2212 No. of Facilities: 429 (estimated) No. of Industries: 8 No. of Occupations: 9 No. of Employees: 4830 (estimated) No. of Female Employees: 1319 (estimated)

氰戊菊酯安全信息

[ 符号 ]:

GHS06, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H315-H319-H335-H410

[ 警示性声明 ]:
P261-P273-P301 + P310-P305 + P351 + P338-P501

[ 危害码 (欧洲) ]:
T: Toxic;N: Dangerous for the environment;

[ 风险声明 (欧洲) ]:
R25;R36/37/38;R50/53;R57

[ 安全声明 (欧洲) ]:
S26-S45-S60-S61

[ 危险品运输编码 ]:
UN 2811 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
CY1576350

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2926909036

氰戊菊酯上下游产品

氰戊菊酯上游产品

氰戊菊酯下游产品

氰戊菊酯制备

由对氯氰苄经烷基化反应、水解、氯化制备α-异丙基对氯苯基乙酰氯，再与间苯氧基甲醛[39515-51-0]及氰化钠反应制得该品。1.烷基化，α-异丙基对氯苯基乙腈的制备将氯氰苄，苯磺酸异丙酯，氢氧化钠按摩尔比1：1.1：3配料加入石油醚中，在70℃左右搅拌反应12h。经水洗、干燥、脱溶后再进行减压蒸馏，收集100-110℃(0.04-0.08kPa)馏分，即得α-异丙基对氯苯基乙腈。含量90%，收率92%以下。烷基化剂苯磺酸异丙酯在反应中转化为苯磺酰内，可回收制备苯酚。烷基化剂也可采用溴代异丙烷或氯代异丙烷，在强碱存在下反应。2.水解，α-异丙基对氯苯基乙酸的制备α-异丙基对氯苯基乙腈与65%的硫酸按摩尔比1：1.3混合，加热至140-145℃反应11h。用溶剂萃取，分除酸层，再经水洗，脱溶，冷却结晶得α-异丙基对氯苯基乙酸，含量90%，熔点85-87℃，收率90%。3.氯化，α-异丙基对氯苯基乙酰氯的制备α-异丙基对氯苯基乙酰氯和五氯化磷按摩尔比1：1.1混合,搅拌升温到130℃，在130-140℃反应1h。冷却排除生成的氯化氢，蒸出副产的三氯氧磷后，减压蒸馏，收集100-103℃（0.4-0.47kPa)馏分，即得α-异丙基对氯苯基乙酰氯，含量95%以上，收率95%以上。4.腈氯苯苯醚菊酯的制备将氰化钠，间苯氧基苯甲醛，α-异丙基对氯苯基乙酰氯按摩尔比1.1：1：1.05依次投入水中，使氰化钠水溶液的浓度为25%。在30-35℃搅拌反应12h。用溶剂萃取，水洗，干燥，减压脱除溶剂后即得腈氯苯苯醚菊酯。原油含量90%以上，收率90%以上。按 GB6694-86，原油的浅棕色至红棕色粘稠液体，一级品有效成分含量≥92.0%，二级品≥85.0%，三级品≥80.0%。原料消耗定额：对氯苯乙腈550kg/t、溴代异丙烷600kg/t、季铵盐相转移催化剂90kg/t、氯化亚砜480kg/t、间苯氧基苯甲醛580kg/t。氰化钠190kg/t。

氰戊菊酯海关

[ 海关编码 ]: 2926909036

[ 中文概述 ]:
2926909036 氟氯苯菊酯、氰戊菊酯、乙氰菊酯。监管条件:S(进出口农药登记证明)。增值税率:17.0%。退税率:9.0%。最低关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: S.进出口农药登记证明

[ Summary ]:
2926909036 cyano(3-phenoxyphenyl)methyl 2-(4-chlorophenyl)-3-methylbutanoate。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:30.0%

氰戊菊酯文献

Endothelial Angiogenesis and Barrier Function in Response to Thrombin Require Ca2+ Influx through the Na+/Ca2+ Exchanger.

J. Biol. Chem. 290 , 18412-28, (2015)

Thrombin acts on the endothelium by activating protease-activated receptors (PARs). The endothelial thrombin-PAR system becomes deregulated during pathological conditions resulting in loss of barrier ...

Atmospheric pressure gas chromatography-time-of-flight-mass spectrometry (APGC-ToF-MS) for the determination of regulated and emerging contaminants in aqueous samples after stir bar sorptive extraction (SBSE).

Anal. Chim. Acta 851 , 1-13, (2014)

This work presents the development, optimization and validation of a multi-residue method for the simultaneous determination of 102 contaminants, including fragrances, UV filters, repellents, endocrin...

[Chemical toxicological identification of esfenvalerate].

Sud. Med. Ekspert. 55(3) , 37-41, (2012)

The optimal conditions for the isolation of esfenvalerate from the biological specimens have been determined. It was shown that this compound can be separated from the endogenous component of a biolog...

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