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3β-羟基-Δ5-胆烯酸

3β-羟基-Δ5-胆烯酸用途

3b-Hydroxy-5-cholenoic acid 是一种内源性的单羟基胆酸,在患有肝胆管状发育不全的儿童体内大量存在。

3β-羟基-Δ5-胆烯酸名称

[ CAS 号 ]:
5255-17-4

[ 中文名 ]:
3B-羟基-D5-胆烯酸

[ 英文名 ]:
3b-Hydroxy-5-cholenoic acid

[中文别名 ]:

[英文别名 ]:

MFCD00069468
Cholenic acid
3b-Hydroxy-5-cholenoic acid
5-cholenic acid-3B-ol
5-CHOLENIC ACID-3BETA-OL
3β-Hydroxy-DELTA5-cholenic Acid

3β-羟基-Δ5-胆烯酸生物活性

[ 描述 ]:

3b-Hydroxy-5-cholenoic acid 是一种内源性的单羟基胆酸,在患有肝胆管状发育不全的儿童体内大量存在。

[ 相关类别 ]:

天然产物 >> 酸和醛

研究领域 >> 代谢疾病

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Back P, et al. Identification of 3 beta-hydroxy-5-cholenoic acid in human meconium. Hoppe Seylers Z Physiol Chem. 1973 Jan;354(1):83-9.

[相关活性小分子]

3β-羟基-Δ5-胆烯酸物理化学性质

[ 密度 ]:
1.11 g/cm3

[ 沸点 ]:
522.8ºC at 760 mmHg

[ 熔点 ]:
232ºC

[ 分子式 ]:
C₂₄H₃₈O₃

[ 分子量 ]:
374.55700

[ 闪点 ]:
284.1ºC

[ 精确质量 ]:
374.28200

[ PSA ]:
57.53000

[ LogP ]:
5.42720

[ 外观性状 ]:
白色至灰白色粉末

[ 折射率 ]:
-39.5 ° (C=1, Dioxane)

[ 储存条件 ]:
室温

3β-羟基-Δ5-胆烯酸MSDS

3β-羟基-Δ5-胆烯酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
22-24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

3β-羟基-Δ5-胆烯酸合成路线

3β-羟基-Δ5-胆烯酸上下游产品

3β-羟基-Δ5-胆烯酸上游产品

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3β-羟基-Δ5-胆烯酸文献

Hepatic bile salt sulfotransferases in the rat: sulfation of 3 beta-hydroxy-5-cholenoate during development.

J. Pediatr. Gastroenterol. Nutr. 12(2) , 260-8, (1991)

Bile salt sulfotransferase (BSS) activity for the fetal bile acid, 3 beta-hydroxy-5-cholenoate, was first detected in the fetus at 18-19 days of gestation and was twofold greater than for glycolithoch...

Determination of 3 beta-hydroxy-5-cholen-24-oic acid and its sulfate in human serum by gas chromatography-mass spectrometry.

Steroids 44(1) , 47-55, (1984)

The glycine conjugate of 3 beta-hydroxy-5-cholen-24-oic acid and its sulfate labeled with deuterium at the C-2, -4, and -23 positions were synthesized. A highly sensitive and specific quantitative ass...

Unusual serum bile acid pattern in children with the syndrome of hepatic ductular hypoplasia.

Clin. Chim. Acta 145(3) , 289-96, (1985)

Fasting bile acids in serum of eight children with the syndrome of hepatic ductular hypoplasia were analyzed by gas chromatography. The children did not receive any kind of treatment during the month ...

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