33538-71-5

• 常用中文名：杀黑星菌素A
• 常用英文名：Venturicidin A
• CAS号：33538-71-5
• 分子式：C₄₁H₆₇NO₁₁
• 分子量：749.971
• 相关类别： 信号通路 跨膜转运 ATP合成酶
• 发布时间：2016-09-15 09:16:45
• 更新时间：2024-01-03 11:12:04
• 文丘里菌素A(Aabomycin A1)是放线菌中的一种ATP合成酶的膜活性天然产物抑制剂。文丘里菌素A增强了氨基糖苷类抗生素庆大霉素对葡萄球菌、肠球菌和铜绿假单胞菌的多重耐药临床分离株的作用。文丘里菌素A对人类胚胎肾(HEK)细胞具有明显的毒性,IC50为31 μg/mL【1】。

名称

• 中文名: 杀黑星菌素A
• 英文名: venturicidin A
• 英文别名: 4,21-dioxabicyclo[15.3.1]heneicosa-9,15,18-trien-3-one, 11-[[3-O-(aminocarbonyl)-2,6-dideoxy-β-D-arabino-hexopyranosyl]oxy]-1-hydroxy-5-[(1R,3R,4S,5S)-4-hydroxy-1,3,5-trimethyl-6-oxooctyl]-6,8,16,18-tetramethyl-, (1R,5S,6R,8R,9E,11R,15E,17R)-; (1R,5S,6R,8R,9E,11R,15E,17R)-1-Hydroxy-5-[(2R,4R,5S,6S)-5-hydroxy-4,6-dimethyl-7-oxononan-2-yl]-6,8,16,18-tetramethyl-3-oxo-4,21-dioxabicyclo[15.3.1]henicosa-9,15,18-trien-11-yl 3-O-carbamoyl-2,6-dideoxy-β-D-arabino-hexopyranoside; Venturicidin A; (1R,5S,6R,8R,9E,11R,15E,17R)-1-Hydroxy-5-[(2R,4R,5S,6S)-5-hydroxy-4,6-dimethyl-7-oxo-2-nonanyl]-6,8,16,18-tetramethyl-3-oxo-4,21-dioxabicyclo[15.3.1]henicosa-9,15,18-trien-11-yl 3-O-carbamoyl-2,6-dide ;oxy-β-D-arabino-hexopyranoside; venturicidin a (aabomycin a1); 4,21-Dioxabicyclo[15.3.1]heneicosa-9,15,18-trien-3-one, 11-[[3-O-(aminocarbonyl)-2,6-dideoxy-β-D-arabino-hexopyranosyl]oxy]-1-hydroxy-5-[(1R,3R,4S,5S)-4-hydroxy-1,3,5-trimethyl-6-oxooctyl]-6,8,16,1 8-tetramethyl-, (1R,5S,6R,8R,9E,11R,15E,17R)-

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 874.9±65.0 °C at 760 mmHg
• 分子式: C₄₁H₆₇NO₁₁
• 分子量: 749.971
• 闪点: 482.9±34.3 °C
• 精确质量: 749.471436
• PSA: 184.07000
• LogP: 5.54
• 蒸汽压: 0.0±0.6 mmHg at 25°C
• 折射率: 1.541

生物活性

• 描述: 文丘里菌素A(Aabomycin A1)是放线菌中的一种ATP合成酶的膜活性天然产物抑制剂。文丘里菌素A增强了氨基糖苷类抗生素庆大霉素对葡萄球菌、肠球菌和铜绿假单胞菌的多重耐药临床分离株的作用。文丘里菌素A对人类胚胎肾(HEK)细胞具有明显的毒性,IC50为31 μg/mL【1】。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 跨膜转运 >> ATP合成酶
• 参考文献:

  [1]. Venkateswarlu Yarlagadda, et al. Venturicidin A, A Membrane-active Natural Product Inhibitor of ATP synthase Potentiates Aminoglycoside Antibiotics. Sci Rep. 2020 May 18;10(1):8134.