1649-18-9

• 常用中文名：阿扎哌隆
• 常用英文名：Azaperone
• CAS号：1649-18-9
• 分子式：C₁₉H₂₂FN₃O
• 分子量：327.396
• 相关类别： 原料药 神经系统用药 抗精神病药
• 发布时间：2018-07-20 23:02:54
• 更新时间：2026-07-02 18:09:53
• Azaperone (R-1929) 是一种多巴胺拮抗剂, 具有一些抗组胺和抗胆碱特性, 有镇静及止吐作用。

名称

• 中文名: 阿扎哌隆
• 英文名: 1-(4-fluorophenyl)-4-(4-pyridin-2-ylpiperazin-1-yl)butan-1-one
• 中文别名: 罗恩 阿扎哌隆 R005272; 甲醇中阿扎哌酮; 氟苯酮吡哌嗪; 氮哌酮(阿扎哌隆); 氯丁酰苯哌嗪/阿扎哌隆; 阿扎哌酮; 阿扎哌隆 阿扎哌隆 氟苯酮哌吡嗪; 4′-氟-4-[4-(2-吡啶基)-1-哌嗪基]丁酰苯; 阿扎哌隆(氮哌酮)检测标准品; 溴化度米芬; 氮杂萘酮; 阿扎佩隆; 氯丁酰苯哌嗪; 乙腈中阿扎哌隆; 氮哌酮; 氟苯酮哌吡嗪; 甲醇中氮哌酮溶液,1000UG/ML; 阿扎哌隆 标准品; 阿扎哌隆,10 MM DMSO 溶液; 氮哌酮(氯丁酰苯哌嗪/阿扎哌隆) 标准品; 乙腈中氮哌酮(阿扎哌隆); 1-(4-氟苯基)-4-[4-(2-吡啶基)-1-哌嗪]-1-丁酮; 1-(4-氟苯基)-4-(4-(吡啶-2-基)哌嗪-1-基)丁-1-酮; 阿扎哌隆/A1A; 氮哌酮 标准品; 1-(4-氟苯基)-4-(4-(2-吡啶基)-1-哌嗪基)-1-丁酮
• 英文别名: 4’-fluoro-4-(4-(2-pyridyl)-1-piperazinyl)butyrophenone; 1-(4-FLUOROPHENYL)-4-[4-(2-PYRIDINYL)-1-PIPERAZINYL]-1-BUTANONE; Azerone; 4'-Fluoro-4-[4-(2-pyridyl)-1-piperazinyl]butyrophenone; 1-(4-fluoro-phenyl)-4-(4-pyridin-2-yl-piperazin-1-yl)-butan-1-one; Stresnil; Azaperone in acetonitrile; 1-(4-Fluorophenyl)-4-(4-(2-pyridinyl)-1-piperazinyl)-1-butanone; Azaperone 1000 μg/mL in Acetonitrile; AZAPERONE(4''-FLUORO-4-(4-(2-PYRIDYL)PIPERAZIN-1-YL)BUTYROPHENONE); AZAPERONE; 1-(4-fluorophenyl)-4-(4-(2-pyridinyl)-1-piperazinyl)-1-butanon; 1-(4-Fluorophenyl)-4-[4-(2-pyridinyl)-1-piperazinyl]-1-butanone; 1-(4-fluorophenyl)-4-[4-(pyridin-2-yl)piperazin-1-yl]butan-1-one; Fluoperidol; 1-<3-(4-Fluorbenzoyl)propyl>-4-(2-pyridyl)piperazin; EINECS 216-715-8; Butyrophenone, 4'-fluoro-4-[4-(2-pyridyl)-1-piperazinyl]; {4'-Fluoro-4-[4-(2-pyridyl)-1-piperazinyl]butyrophenone}; Azaperone in Methanol; r1929; Azeperone; 1-[3-(4-Fluorobenzoyl)propyl]-4-(2-pyridyl)piperazine; Suicalm; 4’-fluoro-4-(4-(2-pyridyl)-1-piperazinyl)-butyrophenon; Azaperone //BP; C10340510 Azaperone; 1-(4-FLUOROPHENYL)-4-[4-(2-PYRIDINYL)-1-PIPERAZINYL]-1-BUTZNONE; Azaperone, 10 mM in DMSO; Azaperon; Azaperone CRS; Azaperone Solution in Methanol, 1000ug/ml; 1-Butanone, 1-(4-fluorophenyl)-4-[4-(2-pyridinyl)-1-piperazinyl]; 4'-Fluoro-4-(4-(2-pyridyl)-1-piperazinyl)butyrophenone; Azaperone 100 μg/mL in Acetonitrile; Azaperone 1-(4-Fluorophenyl)-4-[4-(2-pyridinyl)-1-piperazinyl]-1-butanone; 1-(3-(4-Fluorobenzoyl)propyl)-4-(2-pyridyl)piperazine; Eucalmyl; 4-fluoro-4-(4-(2-pyridyl)piperazin-1-yl)butyrophenone; AZAPERON; 1-(4-Fluorophenyl)-4-(4-(pyridin-2-yl)piperazin-1-yl)butan-1-one; 1-(4-FLUORO-PHENYL)-4-(4-PYRIDIN-2-YL-PIPERAZIN-1-YL)-BUTAN-1-ONE; Sedaperone vet; Azaperone Standd; Pulegone Impurity 1 ((S)-Pulegone); Azaperone VETRANAL; 4'-Fluoro-4-[4-(2-pyridinyl)-1-piperazinyl]butyrophenone; MFCD00866692; R-1929; 4μ-Fluoro-4-[4-(2-pyridyl)-1-piperazinyl]butyrophenone, 1-(4-Fluorophenyl)-4-(4-(2-pyridinyl)-1-piperazinyl)-1-butanone; Azaperone (1.0 mg/mL in Methanol); 1-(4-fluorophenyl)-4-[4-(2-pyridyl)piperazin-1-yl]butan-1-one; Azaperone (USP)

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 499.5±45.0 °C at 760 mmHg
• 熔点: 92-95ºC
• 分子式: C₁₉H₂₂FN₃O
• 分子量: 327.396
• 闪点: 255.9±28.7 °C
• 精确质量: 327.174683
• PSA: 36.44000
• LogP: 2.50
• 外观性状: 白色或灰白色结晶
• 蒸汽压: 0.0±1.3 mmHg at 25°C
• 折射率: 1.568
• 储存条件: 0-6°C

生物活性

• 描述: Azaperone (R-1929) 是一种多巴胺拮抗剂, 具有一些抗组胺和抗胆碱特性, 有镇静及止吐作用。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 多巴胺受体
  信号通路 >> 神经信号通路 >> 多巴胺受体
  研究领域 >> 神经疾病

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : EU4550000 CHEMICAL NAME : Butyrophenone, 4'-fluoro-4-(4-(2-pyridyl)-1-piperazinyl)- CAS REGISTRY NUMBER : 1649-18-9 BEILSTEIN REFERENCE NO. : 0565491 LAST UPDATED : 199612 DATA ITEMS CITED : 10 MOLECULAR FORMULA : C19-H22-F-N3-O MOLECULAR WEIGHT : 327.44 WISWESSER LINE NOTATION : T6N DNTJ D3VR DF& A- BT6NJ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 245 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - ptosis Behavioral - somnolence (general depressed activity) Behavioral - tremor REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 24,1798,1974 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 450 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - ptosis Behavioral - somnolence (general depressed activity) Behavioral - tremor REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 24,1798,1974 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 25 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,185,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 385 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - ptosis Behavioral - somnolence (general depressed activity) Behavioral - tremor REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 24,1798,1974 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 63 mg/kg TOXIC EFFECTS : Behavioral - changes in motor activity (specific assay) Behavioral - rigidity (including catalepsy) REFERENCE : FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 35,605,1980 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 179 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,185,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 42 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - ptosis Behavioral - somnolence (general depressed activity) Behavioral - tremor REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 24,1798,1974 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : >20 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - ptosis Behavioral - somnolence (general depressed activity) Gastrointestinal - nausea or vomiting REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 24,1798,1974 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : >40 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - ptosis Behavioral - somnolence (general depressed activity) Gastrointestinal - nausea or vomiting REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 24,1798,1974 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 202 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - convulsions or effect on seizure threshold REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 24,1798,1974

安全

• 符号: GHS06
• 信号词: Danger
• 危害声明: H301
• 警示性声明: Missing Phrase - N15.00950417
• 个人防护装备: dust mask type N95 (US);Eyeshields;Faceshields;Gloves
• 危害码 (欧洲): Xn: Harmful;
• 风险声明 (欧洲): R22
• 危险品运输编码: UN2811 6.1/PG 3
• RTECS号: EU4550000
• 海关编码: 2942000000

合成路线

34803-66-2 3874-54-2 ~50% 1649-18-9

文献：Jaen; Caprathe; Pugsley; Wise; Akunne Journal of Medicinal Chemistry, 1993 , vol. 36, # 24 p. 3929 - 3936

上下游产品

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34803-66-2 3874-54-2
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海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%