729-99-7

• 常用中文名：磺胺二甲唑
• 常用英文名：sulfamoxol
• CAS号：729-99-7
• 分子式：C₁₁H₁₃N₃O₃S
• 分子量：267.30400
• 相关类别： 分析化学 标准品 法医和兽医标准品
• 发布时间：2018-05-23 08:00:00
• 更新时间：2024-01-02 16:08:08
• Sulfamoxole 是一种广谱化疗抗菌(antimicrobial agent) 试剂。Sulfamoxole 可用于小儿感染的相关研究。

名称

• 中文名: 磺胺二甲唑
• 英文名: sulfamoxole
• 中文别名: 磺胺二甲恶唑; 磺胺噁唑
• 英文别名: SULFAMOXOLE; Sulfamoxol; 4-amino-N-(4,5-dimethyl-1,3-oxazol-2-yl)benzenesulfonamide; Sulphamoxole; Sulfavigor; sulphamoxazole; Oxasulfa; Sulfmidil; Sulfadimethyloxazole; Sulfamoxolum; Justamil; sulfisoxazole; Sulfuno

物化性质

• 密度: 1.411g/cm3
• 沸点: 481ºC at 760 mmHg
• 熔点: 197-199℃
• 分子式: C₁₁H₁₃N₃O₃S
• 分子量: 267.30400
• 闪点: 244.7ºC
• 精确质量: 267.06800
• PSA: 106.60000
• LogP: 3.40940
• 折射率: 1.626
• 储存条件: 库房通风低温干燥
• 计算化学:

  1.疏水参数计算参考值（XlogP）:1.3

  2.氢键供体数量:2

  3.氢键受体数量:6

  4.可旋转化学键数量:3

  5.互变异构体数量:2

  6.拓扑分子极性表面积:107

  7.重原子数量:18

  8.表面电荷:0

  9.复杂度:374

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

生物活性

• 描述: Sulfamoxole 是一种广谱化疗抗菌(antimicrobial agent) 试剂。Sulfamoxole 可用于小儿感染的相关研究。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 参考文献:

  [1]. F Lagler, R Kretzschmar, et al. Toxicological Investigations of the Combination Sulfamoxole/Trimethoprim, a New Broad-Spectrum Chemotherapeutic. Arzneimittelforschung. 1976;26(42):634-43.

  [2]. J A DUGGER, et al. Sulfamoxole (Nuprin), a New Sulfonamide, in Pediatric Practice. J New Drugs. Sep-Oct 1961;1:223-9.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : WO9150000 CHEMICAL NAME : Sulfanilamide, N(sup 1)-(4,5-dimethyl-2-oxazolyl)- CAS REGISTRY NUMBER : 729-99-7 LAST UPDATED : 199706 DATA ITEMS CITED : 7 MOLECULAR FORMULA : C11-H13-N3-O3-S MOLECULAR WEIGHT : 267.33 WISWESSER LINE NOTATION : T5N COJ BMSWR DZ& D1 E1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >12500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 26,634,1976 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2500 mg/kg TOXIC EFFECTS : Behavioral - changes in motor activity (specific assay) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 26,634,1976 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 15200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 10,612,1960 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1800 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - dyspnea REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 26,634,1976 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1285 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 10,612,1960 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 10,612,1960 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1525 mg/kg/9W-C TOXIC EFFECTS : Behavioral - food intake (animal) Endocrine - changes in pituitary weight Endocrine - changes in thyroid weight REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 10,617,1960

安全

• 符号: GHS07
• 信号词: Warning
• 危害声明: H317
• 警示性声明: P280
• 个人防护装备: dust mask type N95 (US);Eyeshields;Faceshields;Gloves
• 危害码 (欧洲): Xi
• 风险声明 (欧洲): 43
• 安全声明 (欧洲): 36/37
• 危险品运输编码: NONH for all modes of transport
• RTECS号: WO9150000

合成路线

45529-92-8 ~% 729-99-7

文献：DE1003737 , ;

110490-38-5 ~% 729-99-7

文献：DE1003737 , ; US2809966 , ;

103640-72-8 ~% 729-99-7

文献：DE1003737 , ; US2809966 , ;

121-60-8 ~% 729-99-7

文献：DE1003737 , ; US2809966 , ;

98-74-8 ~% 729-99-7

文献：DE1003737 , ;

上下游产品

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