77-54-3

• 常用中文名：乙酸柏木酯
• 常用英文名：Cedryl acetate
• CAS号：77-54-3
• 分子式：C₁₇H₂₈O₂
• 分子量：264.403
• 相关类别： 香精与香料 合成香料 羧酸及酯类香料 脂肪族羧酸酯
• 发布时间：2018-07-02 16:35:38
• 更新时间：2026-07-01 19:13:55
• 【用途一】
  用作日化香精原料
  【用途二】
  GB 2760--1996规定为允许使用的食用香料。用于调配木香型香精。
  【用途三】
  可作定香剂用于木香气息的东方型、檀香型、玫瑰麝香型、素心兰型及木香型香精。皂用香精用得较多，且用量可达20%。也用于烟草、皮革香精中。
  【用途四】
  酸类合成香料。

名称

• 中文名: 乙酸柏木酯
• 英文名: Cedryl acetate
• 中文别名: (+)-乙酸柏木酯; 醋酸柏木酯; 乙酸柏木酯,10 MM DMSO 溶液; 八氢-3,6,8,8-四甲基-1H-3A,7-亚甲基甘菊环-6-醇乙酸酯; (3R,3AS,6R,7R,8AS)-3,6,8,8-四甲基八氢-1H-3A,7-甲桥薁-6-基乙酸酯; 乙酸香柏酯; 乙酸柏木酯晶体; 乙酸香柏酯,醋酸柏木酯; 乙酸雪松酯
• 英文别名: 1h-3a,7-methanoazulen-6-ol,octahydro-3,6,8,8-tetramethyl-,acetate,[3theta-(; 7-Methanoazulen-6-ol,octahydro-3,6,8,8-tetramethyl-,acetate,[3R-(3.alpha.,3a.beta.,6.alpha.,7.be1H-3a; CEDROL ACETATE; 7-methanoazulen-6-ol,octahydro-3,6,8,8-tetramethyl-1h-3acetate; [3R-(3alpha,3abeta,6alpha,7beta,8aalpha)]-octahydro-3,6,8,8-tetramethyl-1H-3a,7-methanoazulen-5-yl acetate; (+)-cedryl acetate; CEDRIN ACETATE; CedrylAcetate; (3R,3aS,6R,7R,8aS)-Octahydro-3,6,8,8-tetramethyl-1H-3a,7-methanoazulen-6-ol-6-acetate; cedranylacetate; MFCD00077764; CEDRYL ACETATE LIQUID; Cedryl acetate //BP; CEDRYLACETAT CRIST; 8-beta-h-cedran-8-ol,acetate; 1H-3a,7-Methanoazulen-6-ol, octahydro-3,6,8,8-tetramethyl-, 6-acetate, (3R,3aS,6R,7R,8aS); CEDWOOD ACETATE; OCTAHYDRO-3,6,8,8-TETRAMETHYL-1H-3A,7-METHANOAZULEN-6-YL ACETATE; High quality Cedryl acetate; 1H-3a,7-Methanoazulen-6-ol, octahydro-3,6,8,8-tetramethyl-, acetate; 8-BETA-CEDRAN-8-OL,ACETATE; (3R,3aS,6R,7R,8aS)-3,6,8,8-Tetramethyloctahydro-1H-3a,7-methanoazulen-6-yl acetate; 8βH-Cedran-8-ol acetate; CEDRENYL ACETATE SPECIAL; Cedryl Acetate (Extra, Crystal); Acetic acid cedryl ester; CEDRENYL ACETATE; Cedryl acetate, 10 mM in DMSO; Kashiwagi acid ester; Cedrylacetat; (3R-(3alpha,3abeta,6alpha,7beta,8aalpha))-Octahydro-3,6,8,8-tetramethyl-1H-3a,7-methanoazulen-5-ylacetat; CedrylEster（UncleStructure）; 8betaH-Cedran-8-ol, acetate; [3R-(3α,3aβ,6α,7β,8aα)]-octahydro-3,6,8,8-tetramethyl-1H-3a,7-methanoazulen-5-yl acetate; aceticacid,cedrolester; Acetic acid (3R,8aβ)-decahydro-3β,6α,8,8-tetramethyl-3aα,7α-methanoazulen-6β-yl ester; 1H-3a,7-Methanoazulen-6-ol, octahydro-3,6,8,8-tetramethyl-, acetate, (3R,3aS,6R,7R,8aS); Credrol acetate; EINECS 201-036-1; Cypress acetate; CEDRYL ACETATE P50; cedrylactate; Cedryl Acetate; 1H-3a,7-Methanoazulen-6-ol, octahydro-3,6,8,8-tetramethyl-, acetate, [3R-(3alpha,3abeta,6alpha,7beta,8aalpha)]; (3R,8aβ)-2,3,4,5,6,7,8,8a-Octahydro-3β,6,8,8-tetramethyl-1H-3aα,7α-methanoazulen-6β-ol acetate; Cedryl acetate -3; CEDARWOOD ACETATE; Acetic acid, cedrol ester; OCTAHYDRO-3,6,8,8-TETRAMETHYL-1H-3ALPHA,7-METHANOAZULEN-6-YL ACETATE; Cedranyl acetate; Cedran-8-yl acetate; Supply Cedryl Acetate High Quality; CEDRYL ACETATE CRYSTALS

物化性质

• 密度: 1.0±0.1 g/cm3
• 沸点: 291.7±8.0 °C at 760 mmHg
• 熔点: 44-46 °C
• 分子式: C₁₇H₂₈O₂
• 分子量: 264.403
• 闪点: 137.0±6.0 °C
• 精确质量: 264.208923
• PSA: 26.30000
• LogP: 5.67
• 外观性状: 无色至棕色浓液体
• 蒸汽压: 0.0±0.6 mmHg at 25°C
• 折射率: 1.503
• 储存条件: 库房低温通风干燥
• 分子结构:

  1、 摩尔折射率：76.44

  2、 摩尔体积（cm³/mol）：258.5

  3、 等张比容（90.2K）：630.7

  4、 表面张力（dyne/cm）：35.3

  5、 极化率（10-24cm3）：30.30

• 更多:

  1.熔点（℃）：44-46。

生物活性

• 描述: Cedryl acetate 是一种从草莓番石榴 (Psidium caudatum) 植物分离的三环倍半萜烯。Cedryl acetate 显示 α-葡萄糖苷酶抑制活性。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Sultan S, et al. Fungal transformation of cedryl acetate and α-glucosidase inhibition assay, quantum mechanical calculations and molecular docking studies of its metabolites. Eur J Med Chem. 2013 Apr;62:764-70.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : FJ1680000 CHEMICAL NAME : 8-beta-H-Cedran-8-ol, acetate CAS REGISTRY NUMBER : 77-54-3 LAST UPDATED : 199709 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C17-H28-O2 MOLECULAR WEIGHT : 264.45 WISWESSER LINE NOTATION : L65 B5 A 1B K BXTJ EDV1 E1 G1 G1 K1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : Standard Draize test ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rabbit REFERENCE : FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 12,847,1974 ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 44750 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Skin and Appendages - hair REFERENCE : FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 2,327,1964 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : >5 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 12,847,1974 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84086 No. of Facilities: 53 (estimated) No. of Industries: 3 No. of Occupations: 30 No. of Employees: 4405 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84086 No. of Facilities: 3722 (estimated) No. of Industries: 14 No. of Occupations: 24 No. of Employees: 39484 (estimated) No. of Female Employees: 25142 (estimated)

安全

• 危害码 (欧洲): Xi
• 风险声明 (欧洲): 38
• WGK德国: 2
• RTECS号: FJ1680000
• 海关编码: 2915390090

合成路线

108-22-5 77-53-2 ~% 77-54-3

文献：Tetrahedron Letters, , vol. 27, # 34 p. 4059 - 4062

上下游产品

上游产品  2
108-22-5 77-53-2
下游产品  2
546-28-1 469-61-4

制备

【方法一】
由柏木醇与乙酸或醋酐酯化而成，以硫酸为催化剂。然后中和、洗涤、干燥，再经减压蒸馏而得。

海关

海关编码	2915390090
中文概述	2915390090. 其他乙酸酯. 增值税率:17.0%. 退税率:13.0%. 监管条件:AB(入境货物通关单,出境货物通关单). 最惠国关税:5.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途
监管条件	A.入境货物通关单 B.出境货物通关单
检验检疫	R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验
Summary	2915390090. esters of acetic acid. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:5.5%. General tariff:30.0%