5636-83-9

• 常用中文名：二甲茚定
• 常用英文名：dimethindene
• CAS号：5636-83-9
• 分子式：C₂₀H₂₄N₂
• 分子量：292.41800
• 相关类别： 原料药 抗变态反应药 抗组胺药
• 发布时间：2018-07-02 20:11:41
• 更新时间：2024-01-02 12:44:42
• 二甲亚砜是一种有效的选择性组胺H1拮抗剂。二甲基亚砜损害皮肤伤口愈合(WH)。二甲基亚砜可以阻断K+电流[1][2]。

名称

• 中文名: 二甲茚定
• 英文名: N,N-dimethyl-2-[3-(1-pyridin-2-ylethyl)-1H-inden-2-yl]ethanamine
• 中文别名: 吡啶茚胺
• 英文别名: Triten; Dimethpyrindene; Dimetindeno; N,N-dimethyl-3-[1-(2-pyridyl)ethyl]inden-2-ethylamine; Dimetindene; dimethyl-{2-[3-(1-pyridin-2-yl-ethyl)-inden-2-yl]-ethyl}-amine; Pecofenil; dimethindene; Dimetindenum; Foristal; Fenistil; Forhistal

物化性质

• 密度: 1.065 g/cm3
• 沸点: 416.3ºC at 760 mmHg
• 熔点: 50 - 53 °C
• 分子式: C₂₀H₂₄N₂
• 分子量: 292.41800
• 闪点: 205.6ºC
• 精确质量: 292.19400
• PSA: 16.13000
• LogP: 4.14670
• 折射率: 1.587
• 储存条件: 2-8°C

生物活性

• 描述: 二甲亚砜是一种有效的选择性组胺H1拮抗剂。二甲基亚砜损害皮肤伤口愈合(WH)。二甲基亚砜可以阻断K+电流[1][2]。
• 相关类别:
  信号通路 >> 免疫及炎症 >> 组胺受体
  研究领域 >> 神经疾病
  信号通路 >> 跨膜转运 >> 钾通道
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 组胺受体
• 靶点:

  Human Endogenous Metabolite

• 体外研究: 二甲基亚砜(5-500μM；卵泡封闭的爪蟾卵母细胞)降低克罗马卡林诱导的K+电流,IC50值为29.5μM[2]。
• 体内研究: 二甲基亚砜(0.25 mg；i.p.；一次；C57BL/6小鼠皮肤WH)损害皮肤伤口愈合(WH)并延迟皮肤伤口闭合[1]。动物模型：C57BL/6小鼠,皮肤WH[1]剂量：0.25 mg给药：腹腔注射；结果：与载体处理的小鼠相比,皮肤伤口延迟闭合。

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UT0800000 CHEMICAL NAME : Pyridine, 2-(1-(2-(2-(dimethylamino)ethyl)inden-3-yl)ethyl)- CAS REGISTRY NUMBER : 5636-83-9 BEILSTEIN REFERENCE NO. : 0489974 LAST UPDATED : 199712 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C20-H24-N2 MOLECULAR WEIGHT : 292.46 WISWESSER LINE NOTATION : L56 BHJ C2N1&1 DY1&- BT6NJ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 618 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973 Volume(issue)/page/year: -,95,1973 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 27 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973 Volume(issue)/page/year: -,95,1973 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 45 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973 Volume(issue)/page/year: -,95,1973 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 888 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973 Volume(issue)/page/year: -,95,1973

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