Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Dimethindene
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

DC Chemicals Limited
China
Product Name: Dimethindene
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Stocking Period: 10 Day
Contact: Tony Cao

5636-83-9

5636-83-9 structure

5636-83-9 structure

Name: dimethindene
Chemical Name: N,N-dimethyl-2-[3-(1-pyridin-2-ylethyl)-1H-inden-2-yl]ethanamine
CAS Number: 5636-83-9
Molecular Formula: C₂₀H₂₄N₂
Molecular Weight: 292.41800
Catalog: API Antiallergic Antihistamine
Create Date: 2018-07-02 20:11:41
Modify Date: 2024-01-02 12:44:42
Dimethindene is a potent, selective histamine H1 antagonist. Dimethindene impairs cutaneous wound healing (WH). Dimethindene can block K+ currents[1][2].

Name	N,N-dimethyl-2-[3-(1-pyridin-2-ylethyl)-1H-inden-2-yl]ethanamine
Synonyms	Triten Dimethpyrindene Dimetindeno N,N-dimethyl-3-[1-(2-pyridyl)ethyl]inden-2-ethylamine Dimetindene dimethyl-{2-[3-(1-pyridin-2-yl-ethyl)-inden-2-yl]-ethyl}-amine Pecofenil dimethindene Dimetindenum Foristal Fenistil Forhistal

Description	Dimethindene is a potent, selective histamine H1 antagonist. Dimethindene impairs cutaneous wound healing (WH). Dimethindene can block K+ currents[1][2].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
Target	Human Endogenous Metabolite
In Vitro	Dimethindene (5-500 μM; follicle-enclosed Xenopus oocytes) decreases Cromakalim cromakalim-induced K+ currents with an IC50 value of 29.5 μM[2].
In Vivo	Dimethindene (0.25 mg; i.p.; once; C57BL/6 mice with skin WH) impaires cutaneous wound healing (WH) and delays skin wound closure[1]. Animal Model: C57BL/6 mice with skin WH[1] Dosage: 0.25 mg Administration: intraperitoneal injection; once Result: Delayed skin wound closure as compared to vehicle treated mice.

Density	1.065 g/cm3
Boiling Point	416.3ºC at 760 mmHg
Melting Point	50 - 53 °C
Molecular Formula	C₂₀H₂₄N₂
Molecular Weight	292.41800
Flash Point	205.6ºC
Exact Mass	292.19400
PSA	16.13000
LogP	4.14670
Index of Refraction	1.587
Storage condition	2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UT0800000

CHEMICAL NAME :: Pyridine, 2-(1-(2-(2-(dimethylamino)ethyl)inden-3-yl)ethyl)-

CAS REGISTRY NUMBER :: 5636-83-9

BEILSTEIN REFERENCE NO. :: 0489974

LAST UPDATED :: 199712

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C20-H24-N2

MOLECULAR WEIGHT :: 292.46

WISWESSER LINE NOTATION :: L56 BHJ C2N1&1 DY1&- BT6NJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 618 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973 Volume(issue)/page/year: -,95,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 27 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973 Volume(issue)/page/year: -,95,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 45 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973 Volume(issue)/page/year: -,95,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 888 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973 Volume(issue)/page/year: -,95,1973

Precursor 0
DownStream 1
121367-05-3