982-57-0

• 常用中文名：琥珀酸钠氯霉素
• 常用英文名：Chloramphenicol sodium succinate
• CAS号：982-57-0
• 分子式：C₁₅H₁₅Cl₂N₂NaO₈
• 分子量：445.184
• 相关类别： 分析化学 标准品 药典标准品和杂志标准品
• 发布时间：2018-09-05 21:15:04
• 更新时间：2024-01-02 15:35:14
• Chloramphenicol succinate sodium 是 Chloramphenicol 的前药,具有血液学毒性。Chloramphenicol succinate sodium 是琥珀酸脱氢酶 (SDH) 的竞争底物和抑制剂,可能是其产生毒性的原因。

名称

• 中文名: 琥珀酸钠氯霉素
• 英文名: Chloramphenicol sodium succinate
• 中文别名: 4-[2-[(2,2-二氯乙酰)氨基]-3-羟基-3-(4-硝基苯基)丙氧基]-4-氧代丁酸钠
• 英文别名: (R-(R*,R*))(-)-Butanedioic Acid Mono(2-((2,2-dichloroacetyl)amino)-3-hydroxy-3-(4-nitrophenyl)propyl) Ester Monosodium Salt; Globenicol; Chloramphenicol succinate sodium; Nevimycin; Clorofenicina; Solnicol; 2,2-Dichloro-N-(b-hydroxy-a-(hydroxymethyl)-p-nitrophenethyl)acetamide a-Ester with Sodium Succinate; Chloramphenicol monosuccinate sodium salt; protophenicol; Betamicetin; Nalecin; EINECS 213-568-1; MFCD00083598; Levomycetin-Nalcein; D-threo-(-)-2,2-Dichloro-N-(b-hydroxy-a-(hydroxymethyl)-p-nitrophenethyl)acetamide a-(Sodium Succinate); Cloromoin; butanedioic acid, mono[(2R,3R)-2-[(dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl] ester, monosodium salt; CHLORAMPHENICOL,NASUCCINATE; Butanedioic acid, mono[(2R,3R)-2-[(2,2-dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl] ester, sodium salt (1:1); Chloramphenicol sodium succinate; Sodium 4-{[(2R,3R)-2-[(dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl]oxy}-4-oxobutanoate; Mychel-S; Sodium chloramphenicol succinate

物化性质

• 沸点: 716.3ºC at 760mmHg
• 分子式: C₁₅H₁₅Cl₂N₂NaO₈
• 分子量: 445.184
• 闪点: 387ºC
• 精确质量: 444.010315
• PSA: 161.58000
• LogP: 0.90410
• 外观性状: 白色粉末
• 储存条件: 库房低温通风干燥

生物活性

• 描述: Chloramphenicol succinate sodium 是 Chloramphenicol 的前药,具有血液学毒性。Chloramphenicol succinate sodium 是琥珀酸脱氢酶 (SDH) 的竞争底物和抑制剂,可能是其产生毒性的原因。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Ambrose PJ. Clinical pharmacokinetics of chloramphenicol and chloramphenicol succinate. Clin Pharmacokinet. 1984 May-Jun;9(3):222-38.

  [2]. Ambekar CS, et al. Chloramphenicol succinate, a competitive substrate and inhibitor of succinate dehydrogenase: possible reason for its toxicity. Toxicol In Vitro. 2004 Aug;18(4):441-7.

  [3]. Turton JA, et al. Haemotoxicity of chloramphenicol succinate in the CD-1 mouse and Wistar Hanover rat. Hum Exp Toxicol. 1999 Sep;18(9):566-76.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : AB6905000 CHEMICAL NAME : Acetamide, 2,2-dichloro-N-(beta-hydroxy-alpha-(hydroxymethyl)-p- nitrophenethyl)-, alpha-ester with sodium succinate CAS REGISTRY NUMBER : 982-57-0 LAST UPDATED : 199504 DATA ITEMS CITED : 12 MOLECULAR FORMULA : C15-H15-Cl2-N2-O8.Na MOLECULAR WEIGHT : 445.21 WISWESSER LINE NOTATION : WNR DYQYMVY1&1&1OV2VO &-NA- HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Human - infant DOSE/DURATION : 135 mg/kg/3D-I TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - irritability Lungs, Thorax, or Respiration - respiratory stimulation TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1400 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1530 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 60 gm/kg/5W-I TOXIC EFFECTS : Liver - other changes Blood - normocytic anemia Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 156 gm/kg/26W-I TOXIC EFFECTS : Liver - other changes Kidney, Ureter, Bladder - other changes Blood - normocytic anemia TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 6 gm/kg SEX/DURATION : female 11-14 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 35 gm/kg SEX/DURATION : male 35 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - testes, epididymis, sperm duct TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous DOSE : 1200 mg/kg SEX/DURATION : female 7-12 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) MUTATION DATA TYPE OF TEST : Mutation in mammalian somatic cells TEST SYSTEM : Rodent - mouse Lymphocyte DOSE/DURATION : 2953 mg/L REFERENCE : EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 12(Suppl 13),37,1988 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3875 No. of Facilities: 585 (estimated) No. of Industries: 2 No. of Occupations: 10 No. of Employees: 19269 (estimated) No. of Female Employees: 15096 (estimated)

安全

• 符号: GHS08
• 信号词: Warning
• 危害声明: H351
• 警示性声明: P280
• 个人防护装备: Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
• 危害码 (欧洲): Xn: Harmful;
• 风险声明 (欧洲): R40
• 安全声明 (欧洲): 22-36
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 3
• RTECS号: AB6905000