75225-50-2

• 常用中文名：Lovastatin Hydroxy Acid,钠盐
• 常用英文名：Lovastatin hydroxy acid sodium
• CAS号：75225-50-2
• 分子式：C₂₄H₃₇NaO₆
• 分子量：444.537
• 相关类别： 信号通路 代谢酶/蛋白酶 HMG-CoA还原酶(HMGCR)
• 发布时间：2018-03-16 08:00:00
• 更新时间：2026-07-01 09:03:25
• Lovastatin hydroxy acid sodium (Mevinolinic acid sodium) 是 HMG-CoA 还原酶的高效抑制剂,Ki 为 0.6 nM。

名称

• 中文名: 洛伐他汀钠
• 英文名: Lovastatin sodium salt
• 中文别名: 洛伐他汀杂质2(洛伐他汀杂质B); 甲醇中洛伐他汀羟酸钠盐; LOVASTATIN HYDROXY ACID,钠盐; 洛伐他汀羟酸盐(酸式莫奈可林); 洛伐他丁羟酸钠; 洛伐他汀羟基酸钠; 甲醇中洛伐他汀羟酸钠盐溶液标准物质; 洛伐他汀杂质B钠盐(洛伐他汀羟基酸钠盐); 洛伐他汀羟酸钠盐溶液, 100PPM; 甲醇中洛伐他汀羟酸钠盐溶液,1000ΜG/ML; 洛伐他汀羟基酸钠盐; (3R,5R)-7-((1S,2S,6R,8S,8-2,6-二甲基-8-(((S)-2-甲基丁酰基)氧基)-1,2,6,7,8,8A-六氢萘-1-基)-3,5-二羟基庚酸钠盐; 洛伐他汀杂质B钠盐; 洛伐他汀羟酸钠盐; 化合物:Lovastatin Hydroxy Acid (sodium salt); 洛伐他汀杂质B; 洛伐他汀羟酸钠盐/洛伐他汀杂质B; 化合物：Lovastatin Hydroxy Acid (sodium salt); 洛伐他汀钠Lovastatin Hydroxy Acid; 1,2,6,7,8,8a-六氢-2,6-二甲基-8-(2-甲基丁酰氧基)-1-萘-3',5'-二羟基庚酸钠盐; 洛伐他汀杂质B钠盐(洛伐他汀羟基酸钠); 洛伐他汀杂质B 标准品
• 英文别名: sodium mevinolinate; lovastatin acid sodium salt; lovastatinic sodium salt; pravastatin; lovastatin hydroxy acid sodium salt; LOVASTATIN SODIUM SALT; LovastatinImpurityB75-2; Lovastatin Impurity B as Sodium Salt; LOVASTATIN HYDROXY ACID, SODIUM SALT; [1s-[1a(bs,ds),2a,6b,8b(r),8aa]]-1,2,6,7,8,8a-hexahydro-b,d-dihydroxy-2,6-dimethyl-8-(2-methyl-1-oxobutoxy)-1-naphthalenehtanoic acid monosodium salt; Lovastatin Impurity B; [1S-[1a(bS,dS),2a,6b,8b(R),8aa]]-1,2,6,7,8,8a-Hexahydro-b,d-dihydroxy-2,6-dimethyl-8-(2-methyl-1-oxobutoxy)-1-naphthaleneheptanoic acid monosodium salt; Mevinolin sodium; 1-Naphthaleneheptanoic acid, 1,2,6,7,8,8a-hexahydro-β,δ-dihydroxy-2,6-dimethyl-8-[(2S)-2-methyl-1-oxobutoxy]-, sodium salt, (βR,δR,1S,2S,6R,8S,8aR)- (1:1); lovastatin Na; (3R,5R)-7-[(1S,2S,6R,8S,8-2,6-Di; MB 530B; 6-α-Methylcompactin sodium; Lovastatin sodium salt Solution in Methanol, 1000μg/mL; Lovastatin Impurity B Sodium Salt/Lovastatin Sodium Salt; (3R,5R)-7-[(1S,2S,6R,8S,8-2,6-Dimethyl-8-[[(2S)-2-methylbutanoyl]oxy]-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyhtanoic Acid Sodium Salt (Lovastatin Hydroxy Acid Sodium Salt); Lovastatin Impurity B Sodium Salt; Sodium (3R,5R)-7-[(1S,2S,6R,8S,8aR)-2,6-dimethyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydro-1-naphthalenyl]-3,5-dihydroxyheptanoate; sodium (3R,5R)-7-[(1S,2S,6R,8S,8aR)-2,6-dimethyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoate; (3R,5R)-7-[(1S,2S,6R,8S,8-2,6-Dimethyl-8-[[(2S)-2-methylbutanoyl]oxy]-1,2,6,7,8,8a-hexahydronapht; Lovastatin Hydroxy Acid Sodium SaltQ: What is Lovastatin Hydroxy Acid Sodium Salt Q: What is the CAS Number of Lovastatin Hydroxy Acid Sodium Salt Q: What is the storage condition of Lovastatin Hydroxy Acid Sodium Salt Q: What e the applications of Lovastatin Hydroxy Acid Sodium Salt; Lovastatin Impurity B Sodium Salt (Lovastatin Hydroxy Acid Sodium Salt); Lovastatin Impurity 2(Lovastatin Impurity B); Lovastatin Hydroxy Acid, Sodium Salt, 100ppm; Lovastatin Hydroxy Acid; Sodium (3R,5R)-7-((1S,2S,6R,8S,8-2,6-dimethyl-8-(((S)-2-methylbutanoyl)oxy)-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)-3,5-dihydroxyhtanoate; LOVASTATIN SODIUM; mevinolin sodium salt; Lovastatin Impurity 2

物化性质

• 沸点: 602.3ºC at 760 mmHg
• 熔点: 154-160ºC
• 分子式: C₂₄H₃₇NaO₆
• 分子量: 444.537
• 闪点: 199.1ºC
• 精确质量: 444.248779
• PSA: 106.89000
• LogP: 2.38090
• 储存条件: 2-8°C，密封，干燥

生物活性

• 描述: Lovastatin hydroxy acid sodium (Mevinolinic acid sodium) 是 HMG-CoA 还原酶的高效抑制剂,Ki 为 0.6 nM。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> HMG-CoA还原酶(HMGCR)
  研究领域 >> 代谢疾病
• 靶点:

  Ki: 0.6 nM (HMG-CoA reductase)[1]

• 体外研究: 羟基酸形式的甲基乙烯醇,即甲基乙烯基酸,是3-羟基-3-甲基戊二酰辅酶a还原酶[甲戊二酸：NADP+氧化还原酶(CoA酰化)]的有效竞争抑制剂[1]。
• 参考文献:

  [1]. A W Alberts, eta al. Mevinolin: A Highly Potent Competitive Inhibitor of Hydroxymethylglutaryl-Coenzyme A Reductase and a Cholesterol-Lowering Agent. Proc Natl Acad Sci U S A. 1980 Jul;77(7):3957-61.

安全

• 危害码 (欧洲): Xi

合成路线

75330-75-5 ~% 75225-50-2

文献：US2005/85528 A1, ; Page/Page column 4 ; US 20050085528 A1

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