Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Lovastatin hydroxy acid sodium
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

DC Chemicals Limited
China
Product Name: Lovastatin Sodium
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Lovastatin sodium salt
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

75225-50-2

75225-50-2 structure

75225-50-2 structure

Name: Lovastatin hydroxy acid sodium
Chemical Name: Lovastatin sodium salt
CAS Number: 75225-50-2
Molecular Formula: C₂₄H₃₇NaO₆
Molecular Weight: 444.537
Catalog: Signaling Pathways Metabolic Enzyme/Protease HMG-CoA Reductase (HMGCR)
Create Date: 2018-03-16 08:00:00
Modify Date: 2024-01-02 23:15:19
Lovastatin hydroxy acid sodium (Mevinolinic acid sodium) is a highly potent inhibitor of HMG-CoA reductase with a Ki of 0.6 nM[1].

Name	Lovastatin sodium salt
Synonyms	MB 530B sodium mevinolinate lovastatin acid sodium salt lovastatinic sodium salt pravastatin lovastatin hydroxy acid sodium salt Sodium (3R,5R)-7-[(1S,2S,6R,8S,8aR)-2,6-dimethyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydro-1-naphthalenyl]-3,5-dihydroxyheptanoate sodium (3R,5R)-7-[(1S,2S,6R,8S,8aR)-2,6-dimethyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoate [1S-[1a(bS,dS),2a,6b,8b(R),8aa]]-1,2,6,7,8,8a-Hexahydro-b,d-dihydroxy-2,6-dimethyl-8-(2-methyl-1-oxobutoxy)-1-naphthaleneheptanoic acid monosodium salt 1-Naphthaleneheptanoic acid, 1,2,6,7,8,8a-hexahydro-β,δ-dihydroxy-2,6-dimethyl-8-[(2S)-2-methyl-1-oxobutoxy]-, sodium salt, (βR,δR,1S,2S,6R,8S,8aR)- (1:1) lovastatin Na Lovastatin Hydroxy Acid LOVASTATIN SODIUM mevinolin sodium salt Lovastatin Impurity 2

Description	Lovastatin hydroxy acid sodium (Mevinolinic acid sodium) is a highly potent inhibitor of HMG-CoA reductase with a Ki of 0.6 nM[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> HMG-CoA Reductase (HMGCR) Research Areas >> Metabolic Disease
Target	Ki: 0.6 nM (HMG-CoA reductase)[1]
In Vitro	Mevinolin in the hydroxy-acid form, mevinolinic acid, is a potent competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase [mevalonate: NADP+ oxidoreductase (CoA-acylating)][1].
References	[1]. A W Alberts, eta al. Mevinolin: A Highly Potent Competitive Inhibitor of Hydroxymethylglutaryl-Coenzyme A Reductase and a Cholesterol-Lowering Agent. Proc Natl Acad Sci U S A. 1980 Jul;77(7):3957-61.

Boiling Point	602.3ºC at 760 mmHg
Melting Point	154-160ºC
Molecular Formula	C₂₄H₃₇NaO₆
Molecular Weight	444.537
Flash Point	199.1ºC
Exact Mass	444.248779
PSA	106.89000
LogP	2.38090

Hazard Codes	Xi

75330-75-5 structure

75330-75-5

~%

75225-50-2 structure

75225-50-2

Literature: US2005/85528 A1, ; Page/Page column 4 ; US 20050085528 A1

Precursor 1
75330-75-5
DownStream 0