Lovastatin hydroxy acid sodium

Modify Date: 2025-08-26 14:08:11

Lovastatin hydroxy acid sodium Structure
Lovastatin hydroxy acid sodium structure
Common Name Lovastatin hydroxy acid sodium
CAS Number 75225-50-2 Molecular Weight 444.537
Density N/A Boiling Point 602.3ºC at 760 mmHg
Molecular Formula C24H37NaO6 Melting Point 154-160ºC
MSDS N/A Flash Point 199.1ºC

 Use of Lovastatin hydroxy acid sodium


Lovastatin hydroxy acid sodium (Mevinolinic acid sodium) is a highly potent inhibitor of HMG-CoA reductase with a Ki of 0.6 nM[1].

 Names

Name Lovastatin sodium salt
Synonym More Synonyms

 Lovastatin hydroxy acid sodium Biological Activity

Description Lovastatin hydroxy acid sodium (Mevinolinic acid sodium) is a highly potent inhibitor of HMG-CoA reductase with a Ki of 0.6 nM[1].
Related Catalog
Target

Ki: 0.6 nM (HMG-CoA reductase)[1]

In Vitro Mevinolin in the hydroxy-acid form, mevinolinic acid, is a potent competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase [mevalonate: NADP+ oxidoreductase (CoA-acylating)][1].
References

[1]. A W Alberts, eta al. Mevinolin: A Highly Potent Competitive Inhibitor of Hydroxymethylglutaryl-Coenzyme A Reductase and a Cholesterol-Lowering Agent. Proc Natl Acad Sci U S A. 1980 Jul;77(7):3957-61.

 Chemical & Physical Properties

Boiling Point 602.3ºC at 760 mmHg
Melting Point 154-160ºC
Molecular Formula C24H37NaO6
Molecular Weight 444.537
Flash Point 199.1ºC
Exact Mass 444.248779
PSA 106.89000
LogP 2.38090

 Safety Information

Hazard Codes Xi

 Synthetic Route

~%

Lovastatin hydroxy acid sodium Structure

Lovastatin hydr...

CAS#:75225-50-2

Literature: US2005/85528 A1, ; Page/Page column 4 ; US 20050085528 A1

 Precursor & DownStream

Precursor  1

DownStream  0

 Synonyms

MB 530B
sodium mevinolinate
lovastatin acid sodium salt
lovastatinic sodium salt
pravastatin
lovastatin hydroxy acid sodium salt
Sodium (3R,5R)-7-[(1S,2S,6R,8S,8aR)-2,6-dimethyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydro-1-naphthalenyl]-3,5-dihydroxyheptanoate
sodium (3R,5R)-7-[(1S,2S,6R,8S,8aR)-2,6-dimethyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoate
[1S-[1a(bS,dS),2a,6b,8b(R),8aa]]-1,2,6,7,8,8a-Hexahydro-b,d-dihydroxy-2,6-dimethyl-8-(2-methyl-1-oxobutoxy)-1-naphthaleneheptanoic acid monosodium salt
1-Naphthaleneheptanoic acid, 1,2,6,7,8,8a-hexahydro-β,δ-dihydroxy-2,6-dimethyl-8-[(2S)-2-methyl-1-oxobutoxy]-, sodium salt, (βR,δR,1S,2S,6R,8S,8aR)- (1:1)
lovastatin Na
Lovastatin Hydroxy Acid
LOVASTATIN SODIUM
mevinolin sodium salt
Lovastatin Impurity 2
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