179474-85-2

• 常用中文名：琥珀酸普卡必利
• 常用英文名：Prucalopride Succinate
• CAS号：179474-85-2
• 分子式：C₂₂H₃₂ClN₃O₇
• 分子量：485.958
• 相关类别： 生物化工 抑制剂 神经信号通路(Neuronal Signaling) 5-HT Receptor 激动剂
• 发布时间：2018-03-20 08:00:00
• 更新时间：2026-07-02 18:47:25
• Prucalopride琥珀酸盐是5-HT4受体选择高亲和性激动剂,对5-HT4a和5-HT4b的pKi值分别为8.6和8.1。

名称

• 中文名: 丁二酸 4-氨基-5-氯-2,3-二氢-N-[1-(3-甲氧基丙基)-4-哌啶基]-7-苯并呋喃甲酰胺
• 英文名: 4-amino-5-chloro-N-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-carboxamide,butanedioic acid
• 中文别名: 琥珀酸普鲁卡必利; 丁二酸; 琥珀酸普芦卡必利 4-氨基-5-氯-2,3-二氢-N-[1-(3-甲氧基丙基)-4-哌啶基]-7-苯并呋喃甲酰胺琥珀酸盐; 琥珀酸普芦卡必利; 普卡比利琥珀酸盐; 4-氨基-5-氯-2,3-二氢-N-[1-(3-甲氧基丙基)-4-哌啶基]-7-苯并呋喃甲酰胺; 4-氨基-5-氯-N-(1-(3-甲氧基丙基)哌啶-4-基)-2,3-二氢苯并呋喃-7-甲酰胺琥珀酸盐; 琥珀酸普芦卡必利,10 MM DMSO 溶液; 琥珀酸普卢卡必利; 普芦卡必利工作对照品; 普卡必利琥珀酸盐; 普卡比利丁二酸盐; 琥珀酸普卡必利, 一种5-HT4 受体选择高亲和性激动剂; 琥珀酸普卡比利; 琥珀酸普鲁卡匹利; 普卡必利中间体; 琥珀酸普芦卡必利原料药; 普卡必利(琥珀酸); 普芦卡必利杂质; N-[1-(3-甲氧基丙基)-4-哌啶基]-4-氨基-5-氯-2,3-二氢苯并呋喃-7-甲酰胺琥珀酸盐; 普卢卡必利琥珀酸盐
• 英文别名: TIANFU-CHEM - Prucalopride Succinate; Prucalopride succinate a selective high affinity 5-HT4 rector agonist; PRUCALOPRIDE INTERMEDIATES; Butanedioic acid 4-amino-5-chloro-2,3-dihydro-N-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancboxamide; Prucalopride succinate; Pulucapride Succinate; Prucalopride succinate (R-108512; Prucalopride Succinate, 10 mM in DMSO; Butanedioic acid 4-amino-5-chloro-2,3-dihydro-N-[1-(3-methox; Prucalopride Succinate (R-108512, R-93877); 4-Amino-5-chloro-2,3-dihydro-N-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancboxamide Butanedioic Acid; Prucalopride Succinate //BP; Resolor Succinate; Butanedioic acid, compd. with 4-amino-5-chloro-2,3-dihydro-N-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancboxamide (1:1); Prucalopride (succinate); Prucalopride Succinate WS; Resolor (TN); 7-cyclopenta[b]pyrancboxamide; Prucalopride Succinate API; 4-amino-5-chloro-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-cboxamide succinate; Resolor; Prucalopride Succinate 13CD3Q: What is Prucalopride Succinate 13CD3 Q: What is the CAS Number of Prucalopride Succinate 13CD3; BUTANEDIOIC ACID 4-AMINO-5-CHLORO-2,3-DIHYDRO-N-[1-(3-METHOXYPROPYL)-4-PIPERIDINYL]-7-BENZOFURANCARBOXAMIDE; Prucalopride succinate (USAN); RESOLOR; R-108512; Pucapride Succinate; R-108512; Prucalopride Succinate 4-amino-5-chloro-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3 -dihydrobenzofuran-7-cboxamide succinate; Priucapride succinate; Succinic acid - 4-amino-5-chloro-N-[1-(3-methoxypropyl)-4-piperidinyl]-2,3-dihydro-1-benzofuran-7-carboxamide (1:1); 4-amino-5-chloro-N-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-cboxamide,butanedioic acid; 4-amino-5-chloro-N-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-cboxamide,butanedioicaci; 7-Benzofurancarboxamide, 4-amino-5-chloro-2,3-dihydro-N-[1-(3-methoxypropyl)-4-piperidinyl]-, butanedioate (1:1); Prucalopride Succinat; 4-Amino-5-chloro-N-[1-(3-methoxypropyl)-4-piperidyl]-2,3-dihydrobenzofuran-7-cboxamide Succinate; Prucalopride Impurity; PRUCALOPRIDE SUCCITE

物化性质

• 分子式: C₂₂H₃₂ClN₃O₇
• 分子量: 485.958
• 精确质量: 485.192871
• PSA: 154.91000
• LogP: 3.11750
• 外观性状: 粉末
• 储存条件: -20℃

生物活性

• 描述: Prucalopride琥珀酸盐是5-HT4受体选择高亲和性激动剂,对5-HT4a和5-HT4b的pKi值分别为8.6和8.1。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体
  信号通路 >> 神经信号通路 >> 5-HT受体
  研究领域 >> 其他
• 参考文献:

  [1]. Briejer MR, et al. The in vitro pharmacological profile of prucalopride, a novel enterokinetic compound. Eur J Pharmacol. 2001 Jun 29;423(1):71-83.

  [2]. Johnson DE, et al. The 5-hydroxytryptamine4 receptor agonists prucalopride and PRX-03140 increase acetylcholine and histamine levels in the rat prefrontal cortex and the power of stimulated hippocampal θ oscillations. J Pharmacol Exp Ther. 2012 Jun;341(3)