琥珀酸普卡必利

更新时间：2025-08-23 10:47:44

琥珀酸普卡必利结构式	常用名	琥珀酸普卡必利	英文名	Prucalopride Succinate
	CAS号	179474-85-2	分子量	485.958
	密度	N/A	沸点	N/A
	分子式	C₂₂H₃₂ClN₃O₇	熔点	N/A
	MSDS	N/A	闪点	N/A

琥珀酸普卡必利用途

Prucalopride琥珀酸盐是5-HT4受体选择高亲和性激动剂,对5-HT4a和5-HT4b的pKi值分别为8.6和8.1。

中文名	丁二酸 4-氨基-5-氯-2,3-二氢-N-[1-(3-甲氧基丙基)-4-哌啶基]-7-苯并呋喃甲酰胺
英文名	4-amino-5-chloro-N-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-carboxamide,butanedioic acid
中文别名	普卡比利琥珀酸盐 \| 丁二酸 \| 琥珀酸普卡必利 \| 4-氨基-5-氯-2,3-二氢-N-[1-(3-甲氧基丙基)-4-哌啶基]-7-苯并呋喃甲酰胺 \| 琥珀酸普芦卡必利
英文别名	更多

描述	Prucalopride琥珀酸盐是5-HT4受体选择高亲和性激动剂,对5-HT4a和5-HT4b的pKi值分别为8.6和8.1。
相关类别	信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体信号通路 >> 神经信号通路 >> 5-HT受体研究领域 >> 其他
参考文献	[1]. Briejer MR, et al. The in vitro pharmacological profile of prucalopride, a novel enterokinetic compound. Eur J Pharmacol. 2001 Jun 29;423(1):71-83. [2]. Johnson DE, et al. The 5-hydroxytryptamine4 receptor agonists prucalopride and PRX-03140 increase acetylcholine and histamine levels in the rat prefrontal cortex and the power of stimulated hippocampal θ oscillations. J Pharmacol Exp Ther. 2012 Jun;341(3)

描述

Prucalopride琥珀酸盐是5-HT4受体选择高亲和性激动剂,对5-HT4a和5-HT4b的pKi值分别为8.6和8.1。

相关类别

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体

信号通路 >> 神经信号通路 >> 5-HT受体

研究领域 >> 其他

参考文献

[1]. Briejer MR, et al. The in vitro pharmacological profile of prucalopride, a novel enterokinetic compound. Eur J Pharmacol. 2001 Jun 29;423(1):71-83.

[2]. Johnson DE, et al. The 5-hydroxytryptamine4 receptor agonists prucalopride and PRX-03140 increase acetylcholine and histamine levels in the rat prefrontal cortex and the power of stimulated hippocampal θ oscillations. J Pharmacol Exp Ther. 2012 Jun;341(3)

分子式	C₂₂H₃₂ClN₃O₇
分子量	485.958
精确质量	485.192871
PSA	154.91000
LogP	3.11750
InChIKey	QZRSNVSQLGRAID-UHFFFAOYSA-N
SMILES	COCCCN1CCC(NC(=O)c2cc(Cl)c(N)c3c2OCC3)CC1.O=C(O)CCC(=O)O
外观性状	粉末
储存条件	-20℃

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来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
靶标：HCMV UL50
External Id：HMS1262

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来源：ChEMBL
靶标：Severe acute respiratory syndrome coronavirus 2
External Id：CHEMBL4513082

实验名称：MELAS cybrid survival enhancement under low glucose conditions
来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
靶标：N/A
External Id：HMS1419

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来源：ChEMBL
靶标：Replicase polyprotein 1ab
External Id：CHEMBL4495582

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来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
靶标：Cellular tumor antigen p53
External Id：HMS1485

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Resolor

Prucalopride succinate

BUTANEDIOIC ACID 4-AMINO-5-CHLORO-2,3-DIHYDRO-N-[1-(3-METHOXYPROPYL)-4-PIPERIDINYL]-7-BENZOFURANCARBOXAMIDE

Prucalopride succinate (USAN)

Resolor (TN)

7-Benzofurancarboxamide, 4-amino-5-chloro-2,3-dihydro-N-[1-(3-methoxypropyl)-4-piperidinyl]-, butanedioate (1:1)

Prucalopride Succinat

Succinic acid - 4-amino-5-chloro-N-[1-(3-methoxypropyl)-4-piperidinyl]-2,3-dihydro-1-benzofuran-7-carboxamide (1:1)

Prucalopride (succinate)