138926-19-9

• 常用中文名：伊班膦酸钠
• 常用英文名：Ibandronate sodium
• CAS号：138926-19-9
• 分子式：C₉H₂₄NNaO₈P₂
• 分子量：359.226
• 相关类别： 有机原料 有机膦化合物
• 发布时间：2018-03-18 08:00:00
• 更新时间：2026-07-02 10:24:09
• Ibandronate钠盐一水合物是高活性的含氮二磷酸盐,可用于骨质疏松。

名称

• 中文名: 伊班膦酸钠
• 英文名: Ibandronate Sodium Monohydrate
• 中文别名: 伊班膦酸钠 标准品; 伊班磷酸钠; 伊班膦酸钠一水合物; 伊班膦酸钠水合物; 鲁米昔布; 1-羟基-3-(甲基戊基胺)-丙烷-1,1-双膦酸钠(伊班膦酸钠); 1-羟基-3-(甲基戊基胺)-丙烷-1,1-双膦酸钠 一水合物; 伊班膦酸钠一水物; IBANDRONATE SODIUM, 中间体名 3-(N-METHYL-N-PENTYLAMINO)PROPIONIC ACID SODIUM SALT; 1-羟基-3-(甲基戊基胺)-丙烷-1,1-双膦酸钠水合物; 伊班磷酸钠一水合物; 埃本膦酸钠盐一水化物; 伊班膦酸钠单水合物; 伊班膦酸钠 / 伊班膦酸钠(一水); 伊班膦酸钠,1-羟基-3-(甲基戊基胺)-丙烷-1,1-双膦酸钠
• 英文别名: Ibandrate; Phosphonic acid, P,P'-[1-hydroxy-3-(methylpentylamino)propylidene]bis-, sodium salt, hydrate (1:1:1); Ibandronic acid monosodium salt monohydrate; 1-Hydroxy-3-(methylpentylamino)propylidenebisphosphonatemonosodiummonohydrate; Ibandronate sodium hydrate; sodium,hydroxy-[1-hydroxy-3-[methyl(pentyl)amino]-1-phosphonopropyl]phosphinate,hydrate; Ibandronate Sodium MonohydrateQ: What is Ibandronate Sodium Monohydrate Q: What is the CAS Number of Ibandronate Sodium Monohydrate Q: What is the storage condition of Ibandronate Sodium Monohydrate Q: What e the applications of Ibandronate Sodium Monohydrate; Ibandronate Sodium Hydrate; Ibandronate (Sodium Monohydrate); IBANDRONATE SODIUM SALT; BM-21.0955 monosodium salt monohydrate; Sodium trihydrogen (1-hydroxy-3-(methylpentylamino)propylidene)diphosphonate, monohydrate.; Phosphonic acid, [1-hydroxy-3-(methylpentylamino)propylidene]bis-, sodium salt, hydrate (1:1:1); IBANDRONATE SODIUM/1-HYDROXY-3-(METHYLPENTYLAMINO)PROPYLIDENE; Ibandronate sodium monohydrate; {1-hydroxy-3-[Methyl(pentyl)amino]-1-phosphonopropyl}phosphonic acid; Ibandronate sodium monohydrate - Bio-X; Phosphonic acid, (1-hydroxy-3-(methylpentylamino)propylidene)bis-, monosodium salt, monohydrate; MFCD00912167; Sodium hydrogen(1-hydroxy-3-(methyl(pentyl)amino)-1-phosphonopropyl)phosphonate hydrate; Bondronat monohydrate; Ibronate Sodium; Sodium Trihydrogen (1-Hydroxy-3-(methylpenthylamino)propylidene)diphosphonate Monohydrate; IBANDRONATE SODIUM MONOHYDRATE; Ibandronate sodiuM salt Monhydrate; Ibandromate Monosodium; Ibandronate sodium monohydrate, >=; (1-​Hydroxy-​3-​(methylpentylamino)​propylidene)​bisphosphonic acid sodium; Ibadronate SodiuM; RPR-102289A; [1-Hydroxy-3-(methylpentylamino)propylidene]bisphosphonic acid sodium salt monohydrate; Bonviva; [1-Hydroxy-3-(methylpentylamino)-propylidene]bisphosphonic acid sodium salt; BM 21.0955Na.H2O; Sodium hydrogen {1-hydroxy-3-[methyl(pentyl)amino]-1-phosphonopropyl}phosphonate hydrate (1:1:1); BM-21.0955; Boniva; Boniva monohydrate

物化性质

• 沸点: 587.8ºC at 760 mmHg
• 熔点: 84ºC (dec)
• 分子式: C₉H₂₄NNaO₈P₂
• 分子量: 359.226
• 闪点: 309.3ºC
• 精确质量: 359.087494
• PSA: 170.21000
• LogP: 0.87390
• 外观性状: 白色结晶粉末
• 蒸汽压: 2.88E-16mmHg at 25°C
• 储存条件: -20°C Freezer

生物活性

• 描述: Ibandronate钠盐一水合物是高活性的含氮二磷酸盐,可用于骨质疏松。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 其他
• 参考文献:

  [1]. Morgan, C., S. Jeremiah, and J. Wagstaff, Metronomic administration of ibandronate and its anti-angiogenic effects in vitro. Microvasc Res, 2009. 78(3): p. 453-8.

  [2]. Epplen, R., et al., Differential effects of ibandronate, docetaxel and farnesol treatment alone and in combination on the growth of prostate cancer cell lines. Acta Oncol, 2011. 50(1): p. 127-33.

  [3]. Chesnut, I.C., et al., Effects of oral ibandronate administered daily or intermittently on fracture risk in postmenopausal osteoporosis. J Bone Miner Res, 2004. 19(8): p. 1241-9.

  [4]. Bauss, F., et al., Effects of treatment with ibandronate on bone mass, architecture, biomechanical properties, and bone concentration of ibandronate in ovariectomized aged rats. J Rheumatol, 2002. 29(10): p. 2200-8.

安全

• 危害码 (欧洲): Xn: Harmful;
• 风险声明 (欧洲): R40
• 安全声明 (欧洲): 22-36
• 危险品运输编码: UN 1759 8 / PGIII
• 海关编码: 2922199090

合成路线

114084-78-5 ~% 138926-19-9

文献：WO2005/63779 A2, ; Page/Page column 6 ;

1263180-40-0 ~% 138926-19-9

文献：WO2011/16738 A1, ; Page/Page column 9-10 ;

1310-73-2 114084-78-5 ~% 138926-19-9

文献：WO2008/60609 A1, ; Page/Page column 21 ;

1310-73-2 ~% 138926-19-9

文献：WO2008/14510 A2, ; Page/Page column 24-25 ;

1330-43-4 114084-78-5 ~% 138926-19-9

文献：WO2008/60609 A1, ; Page/Page column 21 ;

127-09-3 114084-78-5 ~% 138926-19-9

文献：WO2008/60609 A1, ; Page/Page column 22 ;

上下游产品

上游产品  4
114084-78-5 1263180-40-0 1330-43-4 127-09-3
下游产品  0

海关

海关编码	2922199090
中文概述	2922199090. 其他氨基醇及其醚，酯和它们的盐（但含一种以上含氧基的除外）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
Summary	2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%