Ibandronate sodium

Modify Date: 2024-01-02 12:16:19

Ibandronate sodium structure	Common Name	Ibandronate sodium
	CAS Number	138926-19-9	Molecular Weight	359.226
	Density	N/A	Boiling Point	587.8ºC at 760 mmHg
	Molecular Formula	C₉H₂₄NNaO₈P₂	Melting Point	84ºC (dec)
	MSDS	N/A	Flash Point	309.3ºC

Use of Ibandronate sodium

Ibandronate is a highly potent nitrogen-containing bisphosphonate used for the treatment of osteoporosis.Target: OthersIbandronate (1.25-2 μM) significantly reduces endothelial cell growth, while ibandronate (2 μM) also significantly reduces capillary-like tube formation and increases apoptosis of endothelial cells. Ibandronate (< 100 μM) dose-dependently increases VEGF expression in endothelial cells [1]. Ibandronate (< 100 μM) inhibits growth of both prostate cancer cell lines (LNCaP and PC-3) in a dose dependent manner [2].Ibandronate administered either daily (2.5 mg) or intermittently (20 mg every other day for 12 doses every 3 months) significantly reduces the risk of new morphometric vertebral fractures by 62% and 50% (p = 0.0006), respectively, in osteoporotic women after 3 years' treatment. Ibandronate administered either daily (2.5 mg) or intermittently (20 mg every other day for 12 doses every 3 months) significantly and progressively increases BMD of lumbar spine by 6.5% and 5.7%, respectively, in osteoporotic women after 3 years' treatment [3]. Ibandronate (< 125 mg/kg s.c.) results in a dose dependent increase in bone mineral density (BMD), trabecular bone volume and trabecular number, load to failure (Fmax), and yield load in long bones and vertebrae in ovariectomized rats, and increased trabecular separation in ovariectomized rats is fully prevented by all doses [4].

Name	Ibandronate Sodium Monohydrate
Synonym	More Synonyms

Description	Ibandronate is a highly potent nitrogen-containing bisphosphonate used for the treatment of osteoporosis.Target: OthersIbandronate (1.25-2 μM) significantly reduces endothelial cell growth, while ibandronate (2 μM) also significantly reduces capillary-like tube formation and increases apoptosis of endothelial cells. Ibandronate (< 100 μM) dose-dependently increases VEGF expression in endothelial cells [1]. Ibandronate (< 100 μM) inhibits growth of both prostate cancer cell lines (LNCaP and PC-3) in a dose dependent manner [2].Ibandronate administered either daily (2.5 mg) or intermittently (20 mg every other day for 12 doses every 3 months) significantly reduces the risk of new morphometric vertebral fractures by 62% and 50% (p = 0.0006), respectively, in osteoporotic women after 3 years' treatment. Ibandronate administered either daily (2.5 mg) or intermittently (20 mg every other day for 12 doses every 3 months) significantly and progressively increases BMD of lumbar spine by 6.5% and 5.7%, respectively, in osteoporotic women after 3 years' treatment [3]. Ibandronate (< 125 mg/kg s.c.) results in a dose dependent increase in bone mineral density (BMD), trabecular bone volume and trabecular number, load to failure (Fmax), and yield load in long bones and vertebrae in ovariectomized rats, and increased trabecular separation in ovariectomized rats is fully prevented by all doses [4].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Others
References	[1]. Morgan, C., S. Jeremiah, and J. Wagstaff, Metronomic administration of ibandronate and its anti-angiogenic effects in vitro. Microvasc Res, 2009. 78(3): p. 453-8. [2]. Epplen, R., et al., Differential effects of ibandronate, docetaxel and farnesol treatment alone and in combination on the growth of prostate cancer cell lines. Acta Oncol, 2011. 50(1): p. 127-33. [3]. Chesnut, I.C., et al., Effects of oral ibandronate administered daily or intermittently on fracture risk in postmenopausal osteoporosis. J Bone Miner Res, 2004. 19(8): p. 1241-9. [4]. Bauss, F., et al., Effects of treatment with ibandronate on bone mass, architecture, biomechanical properties, and bone concentration of ibandronate in ovariectomized aged rats. J Rheumatol, 2002. 29(10): p. 2200-8.

Description

Related Catalog

Signaling Pathways >> Others >> Others

Research Areas >> Others

References

[1]. Morgan, C., S. Jeremiah, and J. Wagstaff, Metronomic administration of ibandronate and its anti-angiogenic effects in vitro. Microvasc Res, 2009. 78(3): p. 453-8.

[2]. Epplen, R., et al., Differential effects of ibandronate, docetaxel and farnesol treatment alone and in combination on the growth of prostate cancer cell lines. Acta Oncol, 2011. 50(1): p. 127-33.

[3]. Chesnut, I.C., et al., Effects of oral ibandronate administered daily or intermittently on fracture risk in postmenopausal osteoporosis. J Bone Miner Res, 2004. 19(8): p. 1241-9.

[4]. Bauss, F., et al., Effects of treatment with ibandronate on bone mass, architecture, biomechanical properties, and bone concentration of ibandronate in ovariectomized aged rats. J Rheumatol, 2002. 29(10): p. 2200-8.

Boiling Point	587.8ºC at 760 mmHg
Melting Point	84ºC (dec)
Molecular Formula	C₉H₂₄NNaO₈P₂
Molecular Weight	359.226
Flash Point	309.3ºC
Exact Mass	359.087494
PSA	170.21000
LogP	0.87390
Vapour Pressure	2.88E-16mmHg at 25°C
Storage condition	-20°C Freezer

Hazard Codes	Xn: Harmful;
Risk Phrases	R40
Safety Phrases	22-36
RIDADR	UN 1759 8 / PGIII
HS Code	2922199090

ibandronic acid

CAS#:114084-78-5

Ibandronate sodium

CAS#:138926-19-9

Literature: WO2005/63779 A2, ; Page/Page column 6 ;

1-hydroxy-3-(N-...

CAS#:1263180-40-0

Ibandronate sodium

CAS#:138926-19-9

Literature: WO2011/16738 A1, ; Page/Page column 9-10 ;

Sodium hydroxide

CAS#:1310-73-2

ibandronic acid

CAS#:114084-78-5

Ibandronate sodium

CAS#:138926-19-9

Literature: WO2008/60609 A1, ; Page/Page column 21 ;

Sodium hydroxide

CAS#:1310-73-2

Ibandronate sodium

CAS#:138926-19-9

Literature: WO2008/14510 A2, ; Page/Page column 24-25 ;

Sodium tetraborate

CAS#:1330-43-4

ibandronic acid

CAS#:114084-78-5

Ibandronate sodium

CAS#:138926-19-9

Literature: WO2008/60609 A1, ; Page/Page column 21 ;

Sodium acetate

CAS#:127-09-3

ibandronic acid

CAS#:114084-78-5

Ibandronate sodium

CAS#:138926-19-9

Literature: WO2008/60609 A1, ; Page/Page column 22 ;

Precursor 4
CAS#:114084-78-5 ibandronic acid CAS#:1263180-40-0 1-hydroxy-3-(N-... CAS#:1330-43-4 Sodium tetraborate CAS#:127-09-3 Sodium acetate
DownStream 0

HS Code	2922199090
Summary	2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

BM-21.0955 monosodium salt monohydrate

Sodium trihydrogen (1-hydroxy-3-(methylpentylamino)propylidene)diphosphonate, monohydrate.

Phosphonic acid, [1-hydroxy-3-(methylpentylamino)propylidene]bis-, sodium salt, hydrate (1:1:1)

Ibandronic acid monosodium salt monohydrate

Ibandronate sodium hydrate

Ibandronate sodium monohydrate

sodium,hydroxy-[1-hydroxy-3-[methyl(pentyl)amino]-1-phosphonopropyl]phosphinate,hydrate

BM 21.0955Na.H2O

(1-Hydroxy-3-(methylpentylamino)propylidene)bisphosphonic acid sodium

Sodium hydrogen {1-hydroxy-3-[methyl(pentyl)amino]-1-phosphonopropyl}phosphonate hydrate (1:1:1)

Phosphonic acid, (1-hydroxy-3-(methylpentylamino)propylidene)bis-, monosodium salt, monohydrate

MFCD00912167

Ibandronate (Sodium Monohydrate)

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China
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DC Chemicals Limited
China
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China
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Zhejiang Hangyu API Co., Ltd
China
Product Name: Ibandronate Sodium
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: Ibandronate Sodium Monohydrate
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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