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18865-48-0

18865-48-0结构式
18865-48-0结构式
  • 常用中文名:放线菌素V
  • 常用英文名:Actinomycin X2
  • CAS号:18865-48-0
  • 分子式:C62H84N12O17
  • 分子量:1269.40000
  • 相关类别: 信号通路 抗感染 细菌
  • 发布时间:2018-09-13 10:46:27
  • 更新时间:2024-01-11 15:27:09
  • Actinomycin X2 (Actinomycin V) 是由许多链霉菌属物种产生的,对 MRSA 表现出强烈的抑制作用,最小抑菌浓度 (MIC) 值为 0.25 μg/mL。Actinomycin X2 可用于癌症和细菌感染。

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中文名 放线菌素V
英文名 actinomycin v
英文别名 5'-Deoxy(Methylthio-d3)adenosine
3h-phenoxazine,actinomycindderiv.
[A3-(4-oxo-L-proline)]-actinomycin-D
5'-S-(Methyl-d3)thioadenosine
3a-(4-oxo-l-proline)-actinomycin
5'-(Methylthio-d3)adenosine
actinomycin-V
ACTINOMYCIN X2
描述 Actinomycin X2 (Actinomycin V) 是由许多链霉菌属物种产生的,对 MRSA 表现出强烈的抑制作用,最小抑菌浓度 (MIC) 值为 0.25 μg/mL。Actinomycin X2 可用于癌症和细菌感染。
相关类别
参考文献

[1]. Zhiyu Chen, et al. Anti-MRSA Activity of Actinomycin X 2 and Collismycin A Produced by Streptomyces globisporusWA5-2-37 From the Intestinal Tract of American Cockroach ( Periplaneta americana). Front Microbiol. 2020 Apr 7;11:555.

密度 1.44g/cm3
沸点 1411.4ºC at 760mmHg
分子式 C62H84N12O17
分子量 1269.40000
闪点 807.4ºC
精确质量 1268.61000
PSA 377.05000
LogP 1.55260
蒸汽压 0mmHg at 25°C
折射率 1.661

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AU2010000
CHEMICAL NAME :
Actinomycin X2
CAS REGISTRY NUMBER :
18865-48-0
LAST UPDATED :
199706
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C62-H84-N12-O17
MOLECULAR WEIGHT :
1269.58

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
300 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 38,1625,1985
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
300 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
38KLAC "Structure-Activity Relationship among the Semisynthetic Antibiotics," Perlman, D., ed., New York, Academic Press, 1977 Volume(issue)/page/year: -,427,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 4(2),48,1980

危害码 (欧洲) T+: Very toxic;
风险声明 (欧洲) 26/27/28-63
安全声明 (欧洲) 22-36/37/39-45
危险品运输编码 UN 2811 6.1/PG 2