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上海化源世纪贸易有限公司
上海市上海市普陀区
产品名：双链聚肌胞苷酸
纯度：98.0%
规格：
联系人：徐经理
联系电话：13311869306

上海脉铂医药科技有限公司
上海市上海市嘉定区
产品名：Poly(I:C)
纯度：98.0%
规格：1g/50mg/10mg/1g
联系人：李先生
联系电话：18916172912

上海阿拉丁生化科技股份有限公司
上海市上海市浦东新区
产品名：聚肌苷-胞酸
纯度：98.0%
规格：100mg/250mg/1g/5g
联系人：阿拉丁
联系电话：400-620-6333

上海创赛科技有限公司
上海市上海市嘉定区
产品名：Poly(I:C)
纯度：98.0%
规格：1ml/50mg/10mg
联系人：夏言
联系电话：18016376636

武汉敬康恩生物医药科技有限公司
湖北省武汉市东西湖区
产品名：聚肌胞
纯度：98.0%
规格：100g/500g/1kg
联系人：周经理
联系电话：15871494362

武汉鼎信通药业有限公司
湖北省武汉市江夏区
产品名：双链聚肌胞
纯度：99.0%
规格：1kg/10kg/50kg/500kg
联系人：董浩
联系电话：13429867250

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24939-03-5生产厂家

24939-03-5价格

24939-03-5

24939-03-5结构式

常用中文名：聚胞苷酸
常用英文名：Polyinosinic-polycytidylic acid
CAS号：24939-03-5
分子式：C₁₉H₂₇N₇O₁₆P₂
分子量：671.403
相关类别：生物化工生物反应调节剂
发布时间：2018-07-23 19:30:06
更新时间：2024-01-02 19:47:41
聚肌苷聚胞苷酸(Poly(I:C))是一种合成的双链RNA(dsRNA),是一种Toll样受体3(TLR3)激动剂。聚肌苷聚胞苷酸存在于一些病毒中,因此通常用于模拟细胞外dsRNA的作用。

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中文名	聚胞苷酸
英文名	poly(I:C)
中文别名	双链聚肌胞聚肌胞苷酸
英文别名	Polyinosinicacid-polycytidylicacid Polyinosinic–polycytidylic acid polyri:polyrc polyi:c Poly(I).Poly(C) polycpolyi 5'-Inosinic acid homopolymer-5'-cytidylic acid homopolymer complex (1_1) 4-Amino-1-(5-O-phosphonopentofuranosyl)-2(1H)-pyrimidinone - 5'-inosinic acid (1:1) Polyinosinic 2(1H)-Pyrimidinone, 4-amino-1-(5-O-phosphonopentofuranosyl)-, compd. with 5'-inosinic acid (1:1)

描述	聚肌苷聚胞苷酸(Poly(I:C))是一种合成的双链RNA(dsRNA),是一种Toll样受体3(TLR3)激动剂。聚肌苷聚胞苷酸存在于一些病毒中,因此通常用于模拟细胞外dsRNA的作用。
相关类别	信号通路 >> 免疫及炎症 >> Toll样受体(TLR) 研究领域 >> 感染研究领域 >> 炎症/免疫
参考文献	[1]. Alexopoulou L, Holt AC, Medzhitov R, Flavell RA. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature. 2001;413(6857):732-738. [2]. Matsumoto M, Kikkawa S, Kohase M, Miyake K, Seya T. Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling. Biochem Biophys Res Commun. 2002;293(5):1364-1369.

沸点	851.4ºC at 760 mmHg
分子式	C₁₉H₂₇N₇O₁₆P₂
分子量	671.403
精确质量	671.098938
PSA	377.00000
外观性状	白色至米白色粉末或晶体
蒸汽压	7.7E-31mmHg at 25°C
储存条件	−20°C
稳定性	本品为人工合成的干扰素诱导物，系由多聚肌苷酸和多聚胞苷酸组成的双股多聚核苷酸。由于干扰素有种属特异性，大量制备供临床应用有困难，故多应用干扰素诱导剂，诱导干扰素。此外聚肌胞尚有免疫佐剂的作用，能刺激网状内皮系统，增强吞噬细胞的吞噬功能，增强抗体的形成，刺激同种移植反应及迟发型过敏反应。有广谱抗病毒作用、抗肿瘤作用。

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TR0175000

CAS REGISTRY NUMBER :: 24939-03-5

LAST UPDATED :: 199106

DATA ITEMS CITED :: 15

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 365 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - nausea or vomiting

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 185 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - nausea or vomiting

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 35 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Behavioral - somnolence (general depressed activity) Behavioral - ataxia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 9500 ug/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Behavioral - somnolence (general depressed activity) Behavioral - ataxia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Behavioral - excitement

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 15 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - somnolence (general depressed activity) Blood - hemorrhage

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 220 ug/kg

TOXIC EFFECTS :: Vascular - other changes Blood - hemorrhage Nutritional and Gross Metabolic - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 28 mg/kg/28D-I

TOXIC EFFECTS :: Vascular - structural changes in vessels Blood - pigmented or nucleated red blood cells

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 2 mg/kg

SEX/DURATION :: female 8-9 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 50 ug/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

TYPE OF TEST :: Cytogenetic analysis

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 250 ug/kg

REFERENCE :: VVIRAT Voprosy Virusologii. Problems of Virology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1956- Volume(issue)/page/year: (5),540,1982 *** REVIEWS *** TOXICOLOGY REVIEW CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971- Volume(issue)/page/year: 2,159,1973

危害码 (欧洲)	Xn
WGK德国	3
RTECS号	TR0175000