品牌现货直购
供应商:我要出现这里






查看所有供应商和价格请点击:

24939-03-5生产厂家

24939-03-5价格

24939-03-5

24939-03-5结构式
24939-03-5结构式
  • 常用中文名:聚胞苷酸
  • 常用英文名:Polyinosinic-polycytidylic acid
  • CAS号:24939-03-5
  • 分子式:C19H27N7O16P2
  • 分子量:671.403
  • 相关类别: 生物化工 生物反应调节剂
  • 发布时间:2018-07-23 19:30:06
  • 更新时间:2024-01-02 19:47:41
  • 聚肌苷聚胞苷酸(Poly(I:C))是一种合成的双链RNA(dsRNA),是一种Toll样受体3(TLR3)激动剂。聚肌苷聚胞苷酸存在于一些病毒中,因此通常用于模拟细胞外dsRNA的作用。

化源商城直购

中文名 聚胞苷酸
英文名 poly(I:C)
中文别名 双链聚肌胞
聚肌胞苷酸
英文别名 Polyinosinicacid-polycytidylicacid
Polyinosinic–polycytidylic acid
polyri:polyrc
polyi:c
Poly(I).Poly(C)
polycpolyi
5'-Inosinic acid homopolymer-5'-cytidylic acid homopolymer complex (1_1)
4-Amino-1-(5-O-phosphonopentofuranosyl)-2(1H)-pyrimidinone - 5'-inosinic acid (1:1)
Polyinosinic
2(1H)-Pyrimidinone, 4-amino-1-(5-O-phosphonopentofuranosyl)-, compd. with 5'-inosinic acid (1:1)
沸点 851.4ºC at 760 mmHg
分子式 C19H27N7O16P2
分子量 671.403
精确质量 671.098938
PSA 377.00000
外观性状 白色至米白色粉末或晶体
蒸汽压 7.7E-31mmHg at 25°C
储存条件 −20°C
稳定性

本品为人工合成的干扰素诱导物,系由多聚肌苷酸和多聚胞苷酸组成的双股多聚核苷酸。由于干扰素有种属特异性,大量制备供临床应用有困难,故多应用干扰素诱导剂,诱导干扰素。此外聚肌胞尚有免疫佐剂的作用,能刺激网状内皮系统,增强吞噬细胞的吞噬功能,增强抗体的形成,刺激同种移植反应及迟发型过敏反应。有广谱抗病毒作用、抗肿瘤作用。

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TR0175000
CAS REGISTRY NUMBER :
24939-03-5
LAST UPDATED :
199106
DATA ITEMS CITED :
15

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
365 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - nausea or vomiting
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
185 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - nausea or vomiting
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
35 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation Behavioral - somnolence (general depressed activity) Behavioral - ataxia
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
9500 ug/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation Behavioral - somnolence (general depressed activity) Behavioral - ataxia
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
20 mg/kg
TOXIC EFFECTS :
Behavioral - excitement
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Primate - monkey
DOSE/DURATION :
15 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - somnolence (general depressed activity) Blood - hemorrhage
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
220 ug/kg
TOXIC EFFECTS :
Vascular - other changes Blood - hemorrhage Nutritional and Gross Metabolic - other changes
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
28 mg/kg/28D-I
TOXIC EFFECTS :
Vascular - structural changes in vessels Blood - pigmented or nucleated red blood cells
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
2 mg/kg
SEX/DURATION :
female 8-9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
DOSE :
50 ug/kg
SEX/DURATION :
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
TYPE OF TEST :
Cytogenetic analysis

MUTATION DATA

TEST SYSTEM :
Rodent - mouse
DOSE/DURATION :
250 ug/kg
REFERENCE :
VVIRAT Voprosy Virusologii. Problems of Virology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1956- Volume(issue)/page/year: (5),540,1982 *** REVIEWS *** TOXICOLOGY REVIEW CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971- Volume(issue)/page/year: 2,159,1973

危害码 (欧洲) Xn
WGK德国 3
RTECS号 TR0175000

24939-03-5 preparation