159811-51-5

• 常用中文名：乌利司他
• 常用英文名：Ulipristal
• CAS号：159811-51-5
• 分子式：C₂₈H₃₅NO₃
• 分子量：433.582
• 相关类别： 生物化工 抑制剂 内分泌及激素(Endocrinology & Hormones) Estrogen/progestogen Receptor 调节剂
• 发布时间：2018-07-25 15:54:38
• 更新时间：2026-07-04 12:37:49
• Ulipristal (CDB 3236) 是一种选择性的性孕酮受体 (progesterone receptor) 调节剂。Ulipristal 与孕激素受体结合,从而抑制 PR 介导的基因表达,并干扰生殖系统中孕激素的活性。

名称

• 中文名: 醋酸乌利司他中间体
• 英文名: (8S,11R,13S,14S,17R)-17-acetyl-11-[4-(dimethylamino)phenyl]-17-hydroxy-13-methyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
• 中文别名: 9-二烯-3; N-二甲基氨基)-苯基]-17Α-羟基-19-去甲孕甾-4; 醋酸乌利司他中间体,10 MM DMSO 溶液; 醋酸优力斯特N-1; 化合物:Ulipristal; 11Beta-[4-(N,N-二甲基氨基)-苯基]-17Alpha-羟基-19-去甲孕甾-4,9-二烯-3,20-二酮; 11Β-[4-(N,N-二甲基氨基)-苯基]-17Α-羟基-19-去甲孕甾-4,9-二烯-3,20-二酮(中八); 乌利司他对照品; 埃拉片杂质; 醋酸乌利司他N1; 11Β-4-(N,N-二甲基氨基)-苯基-17Α-羟基-19-去甲孕甾-4,9-二烯-3,20-二酮(醋酸乌利司他中间体); (8S,11R,13S,14S,17R)-17-乙酰基-11-(4-(二甲基氨基)苯基)-17-羟基-13-甲基-6,7,8,11,12,13,14,15 ,16,17-十氢-1H-环戊二烯并[a]菲; 醋酸乌利司他中间体,11Β-[4-(N,N-二甲基氨基)-苯基]-17Α- 羟基-19-去甲孕甾-4,9-二烯-3,20-二 酮(中八); 20-二酮(中八); 醋酸乌利司他标准品008; 17Α-羟基-11Β-(4-N, N-二甲氨基苯基)-19-去甲孕甾-4, 9-二烯-3, 20-二酮; (8S,11R,13S,14S,17R)-17-乙酰基-11-(4-(二甲基氨基)苯基)-17-羟基-13-甲基-6,7,8,11,12,13,14,15 ,16,17-十氢-1H-环戊二烯并[A]菲-3(2H)-酮; 醋酸乌利司他中间体N-1; 化合物：Ulipristal; 11β-[4-(N,N-二甲基氨基)-苯基]-17α-羟基-19-去甲孕甾-4,9-二烯-3,20-二酮; 尤利普斯塔尔杂质; 乌立妥; 11Β-[4-(N,N-二甲基氨基)-苯基]-17Α-羟基-19-去甲孕甾-4,9-二烯-3,20-二酮; 醋酸乌利司他中间体四; 11B-[4-(N,N-二甲基氨基)-苯基]-17a-羟基-19-去甲孕甾-4,9-二烯-3,20-二酮
• 英文别名: Ulipristal (CDB-2914); Ulipristal, 10 mM in DMSO; Ulipristal，(11beta)-11-[4- (Dimethylamino)phenyl]-17-hydroxy- 19-norpregna-4,9-diene-3,20-dione; 5,6-dimethoxy-2 - (4-pyridyl) methylene-1-indenone; (11β)-11-[4-(Dimethylamino)phenyl]-17-hydroxy-19-norpregna-4,9-diene-3,20-dione; Ulipristal (USAN/INN); Intermediate of Ulinastatin Acetate; 6J5J15Q2X8; (8S,11R,13S,14S,17R)-17-Acetyl-11-(4-(dimethylamino)phenyl)-17-hydroxy-13-methyl-6,7,8,11,12,13,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3(2H)-one; Deacetyl CDB 2914; 19-Norpregna-4,9-diene-3,20-dione,11-[4-(dimethylamino)pheny; 8S,11R,13R,17R)-17-acetyl-11-[4-(dimethylamino)phenyl]-17-hydroxy-13-methyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one; Ulipristal: (11)-11-[4-(Dimethylamino)phenyl]-17-hydroxy-19-norpregna-4,9-diene-3,20-dione; (11beta)-11-[4-(Dimethylamino)phenyl]-17-hydroxy-19-norpregna-4,9-diene-3,20-dione; 19-Norpregna-4,9-diene-3,20-dione, 11-[4-(dimethylamino)phenyl]-17-hydroxy-, (11β); 19-Norpregna-4,9-diene-3,20-dione, 17-(acetyloxy)-11-[4-(dimethylamino)phenyl]-, (11β); (8S,11R,13S,14S,17R)-17-Acetyl-11-(4-(dimethylamino)phenyl)-17-hydroxy-13-methyl-6,7,8,11,12,1; 11β-[4-(N,N-Dimethylamino)-phenyl]-17α-hydroxy-19-norpregna-4,9-diene-3,20-dione (N-1); Ulipristal,11beta-[4-(N,N-diMethylaMino)-phenyl]-17alpha-hydroxy-19-norpregna-4,9-diene-3,20-dione; Ulipristal acetate InterMediate; 11β-[4-(N,N-Dimethylamino)-phenyl]-17α-hydroxy-19; (11beta)-11-[4-(Dimethylamino)phenyl]-17-hydroxy-19-norpregna-4; 11β-[4-(N; 19-Norpregna-4,9-diene-3,20-dione,11-[4-(dimethylamino)phenyl]-17-hydroxy-, (11b); 11-(Acetylthio)decanoic Acid-d20; (8S,11R,13S,14S,17R)-17-acetyl-11-(4-(diMethylaMino)phenyl)-1,2, 7,8,11,12,13,15,16,17-decahydro-17-hydroxy-13-Methyl-6H-cyclopenta [a]phenanthren-3(14H)-one; 11β-[4-(N,N-Dimethylamino)-Phenyl]-17α-Hydroxy-19-Norpregna; 11beta-[4-(N,N-diMethylaMino)-phenyl]-17alpha-hydroxy-19-norpregna-4,9-diene-3,20-dione; Ulipristal-008; 11β-[4-(N,N-dimethylamino)-phenyl]-17α-hydroxy-19-norpregna-4,9-diene-3,20-dione; (8s,11r,13s,14s,17r)-17-acetyl-11-(4-(dimethylamino)phenyl)-17-hydroxy-13-methyl-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydro-3h-cyclopenta[a]phenanthren-3-one; Ulipristal //BP; 9-diene-3; Ulipristal [USAN:INN:BAN]; Deacetyl CDB

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 638.5±55.0 °C at 760 mmHg
• 熔点: 183.5-184.5ºC /Losartan/
• 分子式: C₂₈H₃₅NO₃
• 分子量: 433.582
• 闪点: 340.0±31.5 °C
• 精确质量: 433.261688
• PSA: 57.61000
• LogP: 3.86
• 蒸汽压: 0.0±2.0 mmHg at 25°C
• 折射率: 1.613
• 储存条件: 室温，干燥密封

生物活性

• 描述: Ulipristal (CDB 3236) 是一种选择性的性孕酮受体 (progesterone receptor) 调节剂。Ulipristal 与孕激素受体结合,从而抑制 PR 介导的基因表达,并干扰生殖系统中孕激素的活性。
• 相关类别:
  信号通路 >> 其他 >> 孕激素受体
  研究领域 >> 癌症
  研究领域 >> 内分泌
• 体内研究: Ulipristal(CDB 3236)可能抑制子宫肌瘤的生长。通过抑制或延迟排卵和影响子宫内膜组织,ulipristal可作为紧急避孕措施[1]。
• 参考文献:

  [1]. LIANA PLES, et al. Is Ulipristal Acetate a Liver Toxic Biomolecule? Toxicity assessment of ulipristal acetate. REV.CHIM.(Bucharest).

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