144-74-1

• 常用中文名：磺胺噻唑钠
• 常用英文名：Sulfathiazole sodium
• CAS号：144-74-1
• 分子式：C₉H₈N₃NaO₂S₂
• 分子量：277.298
• 相关类别： 原料药 人工合成抗感染类药 磺胺类药及增效剂
• 发布时间：2018-03-15 08:00:00
• 更新时间：2024-01-02 11:36:55
• 【用途一】
  属磺胺类药，用于治疗敏感菌感染

名称

• 中文名: 磺胺噻唑钠
• 英文名: Sulfathiazole sodium salt
• 中文别名: 磺胺噻唑鈉
• 英文别名: 2-Sulfanilamidothiazole sodium salt; Sodium 2-sulfanilamidothiazole; 4-Amino-N-(2-thiazolyl)benzenesulfonamide sodium salt; sulphathiazole sodium; MFCD00072133; Monosodium 2-sulfanilamidothiazole; N1-2-thiazolylsulfanilamide sodium salt; EINECS 205-638-5; Benzenesulfonamide, 4-amino-N-2-thiazolyl-, sodium salt (1:1); UNII:PV16N742VM; Sodium [(4-aminophenyl)sulfonyl](1,3-thiazol-2-yl)azanide; Sulfathiazole sodium; Sulfathiazole (sodium)

物化性质

• 沸点: 479.5ºC at 760mmHg
• 熔点: 175ºC (form a); 202ºC (form b)
• 分子式: C₉H₈N₃NaO₂S₂
• 分子量: 277.298
• 闪点: 243.8ºC
• 精确质量: 276.995575
• PSA: 112.91000
• LogP: 3.04690
• 蒸汽压: 2.35E-09mmHg at 25°C
• 储存条件: 2-8℃

生物活性

• 描述: Sulfathiazole是短效的磺胺类抗生素。
• 相关类别:
  信号通路 >> 抗感染 >> 细菌
  研究领域 >> 感染
• 参考文献:

  [1]. Perez, S., P. Eichhorn, and D.S. Aga, Evaluating the biodegradability of sulfamethazine, sulfamethoxazole, sulfathiazole, and trimethoprim at different stages of sewage treatment. Environ Toxicol Chem, 2005. 24(6): p. 1361-7.

  [2]. Haller, M.Y., et al., Quantification of veterinary antibiotics (sulfonamides and trimethoprim) in animal manure by liquid chromatography-mass spectrometry. J Chromatogr A, 2002. 952(1-2): p. 111-20.

  [3]. Kahle, M. and C. Stamm, Time and pH-dependent sorption of the veterinary antimicrobial sulfathiazole to clay minerals and ferrihydrite. Chemosphere, 2007. 68(7): p. 1224-31.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : WP2450000 CHEMICAL NAME : Sulfanilamide, N(sup 1)-2-thiazolyl-, monosodium salt CAS REGISTRY NUMBER : 144-74-1 LAST UPDATED : 199701 DATA ITEMS CITED : 7 MOLECULAR FORMULA : C9-H9-N3-O2-S2.Na MOLECULAR WEIGHT : 278.32 WISWESSER LINE NOTATION : T5N CSJ BMSWR DZ &-NA- HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 750 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 45,15,1940 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3800 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 94,338,1953 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1320 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 81,284,1944 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1434 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 71,138,1941 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 708 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JIDXA3 Journal of the Indiana State Medical Association. (Indiana State Medical Assoc., 3935 N. Meridian, Indianapolis, IN 46208) V.1- 1908- Volume(issue)/page/year: 33,503,1940 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Parenteral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1950 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 43,328,1940

安全

• 符号: GHS07
• 信号词: Warning
• 危害声明: H315-H319-H335
• 警示性声明: P261-P305 + P351 + P338
• 个人防护装备: dust mask type N95 (US);Eyeshields;Gloves
• 危害码 (欧洲): Xi:Irritant;
• 风险声明 (欧洲): R36/37/38
• 安全声明 (欧洲): S26-S36-S24/25-S23
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 2
• RTECS号: WP2450000
• 海关编码: 2935009090

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海关

海关编码	2934100090
中文概述	2934100090. 结构上含有一个非稠合噻唑环的化合物(不论是否氢化). 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%