2016-88-8

• 常用中文名：盐酸阿米洛利
• 常用英文名：Amiloride hydrochloride
• CAS号：2016-88-8
• 分子式：C₆H₉Cl₂N₇O
• 分子量：266.088
• 相关类别： 原料药 泌尿系统用药 利尿药
• 发布时间：2018-05-20 08:00:00
• 更新时间：2024-01-02 18:29:15
• Amiloride (hydrochloride)是上皮钠通道 ENaC 抑制剂和尿激酶型纤溶酶原激活物的竞争性抑制剂 (uPA)。

名称

• 中文名: 盐酸阿米洛利
• 英文名: amiloride hydrochloride
• 中文别名: 阿米洛利; 阿米洛利盐酸盐水合物; 阿米洛利盐酸盐水合物; N-脒基-3,5-二氨基-6-氯吡嗪甲酰胺盐酸盐; 氨氯吡咪
• 英文别名: GUANAMPRAZINE; amiprazidine; 2-Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-, hydrochloride (1:1); 3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide hydrochloride; N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride hydrate; 3,5-Diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide Hydrochloride Hydrate; Amiloridhydrochlorid; N-amidino-3,5-diamino-6-chloro-pyrazinecarboxamide hydrochloride; AMIPRAMIDIN; Amiloride HCl; 3,5-Diamino-N-carbamimidoyl-6-chloro-2-pyrazinecarboxamide hydrochloride (1:1); 3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide chlorhydrate; N-amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride; 3,5-diamino-N-[amino(imino)methyl]-6-chloropyrazine-2-carboxamide hydrochloride; Arumil; AMipraMidine; HCL AMILORIDE HCL; UNII-7M458Q65S3; Midamor; Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-, monohydrochloride; 3,5-Diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide hydrochloride (1:1); AMIPRAMIZIDE; amiloride monohydrochloride; amiloridechloride; Amiloride (hydrochloride); Guanamprazine hydrochloride; AMipraMizi; EINECS 217-958-2; MFCD03703482; 2-pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-, monohydrochloride; Amiloride hydrochloride

物化性质

• 密度: 2.11 g/cm3
• 沸点: 628.1ºC at 760 mmHg
• 熔点: 293-294°C
• 分子式: C₆H₉Cl₂N₇O
• 分子量: 266.088
• 闪点: 333.7ºC
• 精确质量: 265.024567
• PSA: 156.79000
• LogP: 2.07300
• 外观性状: 淡黄色固体
• 蒸汽压: 1.08E-15mmHg at 25°C
• 储存条件:

  保持贮藏器密封、储存在阴凉、干燥的地方，确保工作间有良好的通风或排气装置

• 稳定性:

  如果遵照规格使用和储存则不会分解，未有已知危险反应，避免氧化物

• 水溶解性: H2O: 50 mg/mL, clear, yellow-green | <0.1 g/100 mL at 19.5 ºC
• 分子结构:

  1、 摩尔折射率：49.91

  2、 摩尔体积（m³/mol）：108.5

  3、 等张比容（90.2K）：353.6

  4、 表面张力（dyne/cm）：112.5

  5、 极化率（10 ^-24cm ³）：19.78

• 计算化学:

  1、 疏水参数计算参考值（XlogP）：

  2、 氢键供体数量：5

  3、 氢键受体数量：7

  4、 可旋转化学键数量：1

  5、 互变异构体数量：33

  6、 拓扑分子极性表面积（TPSA）：159

  7、 重原子数量：16

  8、 表面电荷：0

  9、 复杂度：279

  10、同位素原子数量：0

  11、确定原子立构中心数量：0

  12、不确定原子立构中心数量：0

  13、确定化学键立构中心数量：0

  14、不确定化学键立构中心数量：0

  15、共价键单元数量：2

• 更多:

  1. 状：粉末

  2. 密度（g/mL,25ºC）：未确定

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC）：293.5

  5. 沸点（ºC）：未确定

  6. 沸点（ºC，0.5mmHg）：未确定

  7. 折射率：未确定

  8. 闪点（°F）：未确定

  9. 比旋光度（ºF）：未确定

  10. 自燃点或引燃温度（ºC）：未确定

  11. 蒸气压（kPa,20ºC）：未确定

  12. 饱和蒸气压（kPa,25ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（辛醇/水）分配系数的对数值：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性：能溶解于水的

生物活性

• 描述: Amiloride (hydrochloride)是上皮钠通道 ENaC 抑制剂和尿激酶型纤溶酶原激活物的竞争性抑制剂 (uPA)。
• 相关类别:
  信号通路 >> 跨膜转运 >> 钠通道
  研究领域 >> 代谢疾病
• 靶点:

  ENaC, uPA[1]

• 体外研究: 阿米洛利阻断δβγ通道,IC50为2.6μM。阿米洛利对δβγENaC的Ki是αβγ通道的26倍(αβγENaC为0.1μM)。与αβγ通道相比,阿米洛利对δβγENaC的阻断更加依赖于电压。阿米洛利对δαβγ通道的Ki在-120和+80 mV分别为920和13.7μM,与αβγ和δβγ通道的差异显着[1]。阿米洛利是上皮钠通道(ENaC)的相对选择性抑制剂,在0.1至0.5μM的浓度范围内具有IC 50(达到50％离子通道抑制所需的浓度)。阿米洛利是Na +/H +交换剂(NHE)的相对较差的抑制剂,在低外部[Na +]存在下IC50低至3μM,但在高[Na +]存在下高达1mM。 Amiloride是Na +/Ca2 +交换剂(NCX)中更弱的抑制剂,IC50为1 mM。已知抑制ENaC的阿米洛利(1μM)和亚微摩尔剂量的苯甲酰胺(30nM)通过阻断ENaC蛋白的活性来抑制肌原性血管收缩反应以增加灌注压。阿米洛利完全抑制Na +内流,其剂量已知对血管平滑肌细胞(VSMC)中的ENaC(1.5μM)具有相对特异性[2]。
• 体内研究: 发现阿米洛利(1mg/kg /天)皮下注意逆转胶原沉积的初始增加并防止DOCA-盐高血压大鼠的任何进一步增加。与对照组相比,阿米洛利可延缓蛋白尿的发作,改善饮用盐水,易卒中的自发性高血压大鼠(SHRSP)的脑和肾组织学评分。阿米洛利拮抗或预防醛固酮在这些细胞中以及在具有盐依赖性高血压的动物的心血管和肾组织中的作用[2]。
• 参考文献:

  [1]. Ji, H.L., et al. delta ENaC: a novel divergent amiloride-inhibitable sodium channel. Am J Physiol Lung Cell Mol Physiol, 2012. 303(12): p. L1013-26.

  [2]. Teiwes J, et al. Epithelial sodium channel inhibition in cardiovascular disease. A potential role for amiloride. Am J Hypertens. 2007 Jan;20(1):109-17.

MSDS

Material Safety Data Sheet Section1. Identification of the substance Product Name: Amiloride HCl dihydrate Synonyms: Section2. Hazards identification Harmful by inhalation, in contact with skin, and if swallowed. H301:Toxic if swallowed P264:Wash thoroughly after handling P270:Do not eat, drink or smoke when using this product P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician P321:Specific treatment (see on this label) P405:Store locked up Section3. Composition/information on ingredients. Ingredient name:Amiloride HCl dihydrate CAS number:2016-88-8 Section4. First aid measures Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing contaminated clothing and shoes. If irritation persists, seek medical attention. Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical attention. Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention. Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention. Section5. Fire fighting measures In the event of a fire involving this material, alone or in combination with other materials, use dry powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus should be worn. Section6. Accidental release measures Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national standards. Respiratory precaution:Wear approved mask/respirator Hand precaution:Wear suitable gloves/gauntlets Skin protection:Wear suitable protective clothing Eye protection:Wear suitable eye protection Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container for disposal. See section 12. Environmental precautions: Do not allow material to enter drains or water courses. Section7. Handling and storage Handling:This product should be handled only by, or under the close supervision of, those properly qualified in the handling and use of potentially hazardous chemicals, who should take into account the fire, health and chemical hazard data given on this sheet. Storage:Store in closed vessels. Section8. Exposure Controls / Personal protection Engineering Controls: Use only in a chemical fume hood. Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles. General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse. Section9. Physical and chemical properties Appearance:Not specified Boiling point:No data Melting point:No data Flash point:No data Density:No data Molecular formula:C6H8ClN7O.ClH.2H2O Molecular weight:302.1 Section10. Stability and reactivity Conditions to avoid: Heat, flames and sparks. Materials to avoid: Oxidizing agents. Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen chloride. Section11. Toxicological information No data. Section12. Ecological information No data. Section13. Disposal consideration Arrange disposal as special waste, by licensed disposal company, in consultation with local waste disposal authority, in accordance with national and regional regulations. Section14. Transportation information UN Number:UN2811 Class: 6.1 Packing group: III Proper shipping name: TOXIC SOLIDS, ORGANIC, N.O.S. (Amiloride HCl dihydrate) Section15. Regulatory information No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302, or have known CAS numbers that exceed the threshold reporting levels established by SARA Title III, Section 313. SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

毒理学数据: 1、致突变性 微生物鼠伤寒沙门氏菌突变：1mg/plate。 生态学数据: 对水是稍微有危害的不要让未稀释或大量的产品接触地下水、水道或者污水系统，若无政府许可，勿将材料排入周围环境。 CHEMICAL IDENTIFICATION RTECS NUMBER : UQ2275500 CHEMICAL NAME : Pyrazinecarboxamide, N-amidino-3,5-diamino-6-chloro-, monohydrochloride CAS REGISTRY NUMBER : 2016-88-8 LAST UPDATED : 199504 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C6-H8-Cl-N7-O.Cl-H MOLECULAR WEIGHT : 266.12 HEALTH HAZARD DATA ACUTE TOXICITY DATA MUTATION DATA TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 1 mg/plate REFERENCE : EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 19(Suppl 21),2,1992 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3814 No. of Facilities: 32 (estimated) No. of Industries: 2 No. of Occupations: 9 No. of Employees: 4480 (estimated) No. of Female Employees: 1822 (estimated)

安全

• 危害码 (欧洲): T:Toxic
• 风险声明 (欧洲): R25
• 安全声明 (欧洲): S36-S45
• 危险品运输编码: UN 2811 6.1/PG 3
• WGK德国: 3
• RTECS号: UQ2275500
• 包装等级: II
• 危险类别: 6.1(a)
• 海关编码: 29339980

海关

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%