157810-81-6

• 常用中文名：硫酸茚地那韦
• 常用英文名：Indinavir Sulfate
• CAS号：157810-81-6
• 分子式：C₃₆H₄₉N₅O₈S
• 分子量：711.868
• 相关类别： 原料药 人工合成抗感染类药 抗病毒类药
• 发布时间：2018-09-30 14:20:25
• 更新时间：2026-06-30 12:46:54
• Indinavir(MK-639; L735524)硫酸盐是HIV蛋白酶抑制剂,具有很好的口服生物相容性。

名称

• 中文名: 硫酸茚地那韦
• 英文名: Indinavir sulfate
• 中文别名: (1(1S,2R),5(S))-2,3,5-三脱氧-N-(2,3-二氢-2-羟基-1H-茚-1-基)-5-[2-[[(1,1-二甲基乙基)氨基]羰基]-4-(3-吡啶甲基)-1-哌嗪基]-2-(苯甲基)-D-赤式-戊酰胺硫酸盐; 茚地那韦(硫酸盐); 硫酸印地那韦; 茚地那非硫酸盐; 硫酸英地那韦; 硫酸茚地那韦,10 MM DMSO 溶液; 茚地那维; 硫酸吲地纳韦; 硫酸茚地那维; 左乙拉西坦注射; (S)-1-((2S,4R)-4-苄基-2-羟基-5-(((1S,2R)-2-羟基-2,3-二氢-1H-茚-1-基)氨基)-5-氧代戊基)-N-(叔丁基)-4-(吡啶-3-基甲基)哌嗪-2-甲酰胺硫酸盐
• 英文别名: CRIXIVAN; Indinavir, MK 639, L; Indinivar sulphate; Indinavir sulfateQ: What is Indinavir sulfate Q: What is the CAS Number of Indinavir sulfate Q: What is the storage condition of Indinavir sulfate; (2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5-[[(1S,2R)-2-hydroxyinda; INDINAVIR SULPHATE; Indinavir (sulfate); MK-639 sulfate; Indinavir sulfate###Unii-9mg78X43zt; (1(1s,2r),5(s))-2,3,5-trideoxy-n-(2,3-dihydro-2-hydroxy-1h-inden-1-yl)-5-(2-(((1,1-dimethylethyl)amino)carbonyl)-4-(3-pyridinylmethyl)-1-piperazinyl)-2-(phenylmethyl)-d-erythro-pentonamide sulfate; indinavirsulfate(subjecttopatentfree); Indinavir sulfate ethanolate; (2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5-{[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino}-5-oxopentyl]-N-tert-butyl-4-(pyridin-3-ylmethyl)piperazine-2-carboxamide sulfate (salt); N-tert-butyl-1-[2-hydroxy-5-[(2-hydroxy-2,3-dihydro-1H-inden-1-yl)amino]-5-oxo-4-(phenylmethyl)pentyl]-4-(3-pyridinylmethyl)-2-piperazinecboxamide; (2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5-[[(1S,2R)-2-hydroxyindan-1-yl]amino]-5-oxo-pentyl]-N-tert-butyl-4-(3-pyridylmethyl)piperazine-2-cboxamide; Levetiracetam (Injection ade); (2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5-{[(1S,2R)-2-hydroxy-2,3-dihydro-1H-indén-1-yl]amino}-5-oxopentyl]-N-(1,1-diméthyléthyl)-4-(pyridin-3-ylméthyl)pipérazine-2-carboxamide sulfate (salt); INDIGOWOADROOTEXTRACT; IDV; (2S)-1-[(2S,4R)-4-Benzyl-2-hydroxy-5-{[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino}-5-oxopentyl]-N-tert-butyl-4-(pyridin-3-ylmethyl)piperazine-2-carboxamide sulfate (1:1) (non-preferred name); (2S)-1-[(2S,4R)-4-Benzyl-2-hydroxy-5-{[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino}-5-oxopentyl]-N-(2-methyl-2-propanyl)-4-(3-pyridinylmethyl)-2-piperazinecarboxamide sulfate (1:1) (non-preferred name); (2S)-1-[(2S,4R)-4-Benzyl-2-hydroxy-5-{[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino}-5-oxopentyl]-N-tert-butyl-4-(pyridin-3-ylmethyl)piperazin-2-carboxamidsulfat(salt); MK-639,Crixivan; D-erythro-Pentonamide, 2,3,5-trideoxy-N-[(1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]-5-[(2S)-2-[[(1,1-dimethylethyl)amino]carbonyl]-4-(3-pyridinylmethyl)-1-piperazinyl]-2-(phenylmethyl)-, sulfate (1:1); Indinavir sulfate 157-6; (S)-1-((2S,4R)-4-Benzyl-2-hydroxy-5-(((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)amino)-5-oxopentyl)-N-(tert-butyl)-4-(pyridin-3-ylmethyl)piperazine-2-cboxamide sulfate; Indinavir & Indinavir Sulfate; (2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5-{[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino}-5-oxopentyl]-N-tert-butyl-4-(pyridin-3-ylmethyl)piperazine-2-carboxamide sulfate (salt) (non-preferred name); Crixivan; MK-639; 2,3,5-Trideoxy-N-[(1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]-5-[(2S)-2[[(1,1-dimethylethyl)amino]carbonyl]-4-(3-pyridinylmethyl)-1-piperazinyl]-2-(phenylmethyl)-D-erythro-pentonamide; Indinavir sulfate, 10 mM in DMSO; Indinavir sulfate //BP; INDINAVIR SULFATE; L735524 sulfate

物化性质

• 沸点: 877.9ºC at 760 mmHg
• 熔点: 150-153ºC
• 分子式: C₃₆H₄₉N₅O₈S
• 分子量: 711.868
• 闪点: 484.7ºC
• 精确质量: 711.330200
• PSA: 201.01000
• LogP: 3.95250
• 外观性状: 白色粉末
• 蒸汽压: 5.56E-33mmHg at 25°C
• 储存条件: -20°C Freezer
• 水溶解性: Freely soluble in water, soluble in methanol, practically insoluble in heptane.

生物活性

• 描述: Indinavir(MK-639; L735524)硫酸盐是HIV蛋白酶抑制剂,具有很好的口服生物相容性。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> HIV蛋白酶
  信号通路 >> 抗感染 >> HIV
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Stein, D.S., et al., A 24-week open-label phase I/II evaluation of the HIV protease inhibitor MK-639 (indinavir). AIDS, 1996. 10(5): p. 485-92.

  [2]. Liu, F., et al., Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistant mutations L24I, I50V, and G73S. J Mol Biol, 2005. 354(4): p. 789-800.

安全

• 安全声明 (欧洲): S36/37
• 海关编码: 2933990090

海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%