134381-21-8

• 常用中文名：环氧酶素
• 常用英文名：Epoxomicin
• CAS号：134381-21-8
• 分子式：C₂₈H₅₀N₄O₇
• 分子量：554.719
• 相关类别： 信号通路 代谢酶/蛋白酶 蛋白酶体
• 发布时间：2017-06-03 02:36:52
• 更新时间：2026-07-03 22:15:54
• Epoxomicin是一种可渗透细胞且不可逆的蛋白酶体抑制剂,主要抑制胰凝乳蛋白酶样活性。

名称

• 中文名: N-乙酰基-N-甲基-L-异亮氨酰-L-异亮氨酰-N-[(1S)-3-甲基-1-[[(2R)-2-甲基-2-环氧乙烷基]羰基]丁基]-L-苏氨酰胺
• 英文名: Epoxomicin
• 中文别名: OXOMICIN艾泼米辛; 环氧霉素; 环氧甲酮四肽蛋白酶体抑制剂, 一种选择性蛋白酶体抑制剂; oxomicin (BU-4061T) 环氧酶素,S7038; (2S,3S)-N-((2S,3R)-3-羟基-1-(((S)-4-甲基-1-((R)-2-甲基环氧乙烷-2-基)-1-氧代戊-2-基)氨基)-1-氧代丁-2-基)-3-甲基-2-((2S,3S)-3-甲基-3-(N-甲基乙酰胺基)戊酰胺基)戊酰胺; 环氧酶素,10 MM DMSO 溶液; 20S蛋白酶体抑制剂OXOMICIN); oxomicin (BU-4061T) 环氧酶素，S7038; 埃泼米辛; 艾泼米辛; 环氧甲酮四肽OXOMYCIN,OX)
• 英文别名: 134-8 supplier in China; N-Acetyl-N-methyl-L-isoleucyl-L-isoleucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]-L-threoninamide; oxomicin(BU-4061T); n-acetyl-n-methyl-l-isoleucyl-l-isoleucyl-n-[(1s)-3-methyl-1-[[(2r)-2-methyloxiranyl]carbonyl]butyl]-l-threoninamide; OXOMICIN, SYNTHETIC; S7038,BU-4061T; Epoxomicin (BU-4061T); oxomicin, 20S proteasome inhibitor; oxomicin, 10 mM in DMSO; OXOMICIN;BU4061T;BU-4061T; OXOMICIN; BU-4061T,Aids; N-Acetyl-N-methyl-L-isoleucyl-L-isoleucyl-N-{(2S)-4-methyl-1-[(2R)-2-methyl-2-oxiranyl]-1-oxo-2-pentanyl}-L-threoninamide; (2S,3S)-2-[[(2S,3S)-2-[acetyl(Methyl)amino]-3-Methylpentanoyl]amino]-N-[(2S,3R)-3-hydroxy-2-[[(2S)-4-Methyl-1-[(2R)-2-Methyloxiran-2-yl]-1-oxopentan-2-yl]amino]butanoyl]-3-MethylpentanaMide; Aids010837; oxomicin solution; (2S,3S)-2-[[(2S,3S)-2-[acetyl(methyl)amino]-3-methylpentanoyl]amino]-N-[(2S,3R)-3-hydroxy-2-[[(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]amino]butanoyl]-3-methylpentanamide; L-Threoninamide, N-acetyl-N-methyl-L-isoleucyl-L-isoleucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]; L-Threoninamide, N-acetyl-N-methyl-L-isoleucyl-L-isoleucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyloxiranyl]carbonyl]butyl]; oxomicin a selective proteasome inhibitor; Aids-010837; BU-4061T; (2R)-2-[ACETYL-(N-METHYL-L-ISOLEUCYL)-L-ISOLEUCYL-L-THREONYL-L-LEUCYL]-2-METHYLOXIRANE

物化性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 795.7±60.0 °C at 760 mmHg
• 熔点: 107-109ºC
• 分子式: C₂₈H₅₀N₄O₇
• 分子量: 554.719
• 闪点: 435.0±32.9 °C
• 精确质量: 554.367920
• PSA: 157.44000
• LogP: 3.32
• 外观性状: 白色至灰白色固体
• 蒸汽压: 0.0±6.3 mmHg at 25°C
• 折射率: 1.504
• 储存条件: -20°C

生物活性

• 描述: Epoxomicin是一种可渗透细胞且不可逆的蛋白酶体抑制剂,主要抑制胰凝乳蛋白酶样活性。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 蛋白酶体
  研究领域 >> 癌症
  天然产物 >> 其他
• 参考文献:

  [1]. Kim KB, et al. Proteasome inhibition by the natural products epoxomicin and dihydroeponemycin: insights into specificity and potency. Bioorg Med Chem Lett. 1999 Dec 6;9(23):3335-40.

  [2]. Hanada M, et al. Epoxomicin, a new antitumor agent of microbial origin. J Antibiot (Tokyo). 1992 Nov;45(11):1746-52.

  [3]. Garrett IR, et al. Selective inhibitors of the osteoblast proteasome stimulate bone formation in vivo and in vitro. J Clin Invest. 2003 Jun;111(11):1771-82.

  [4]. McNaught KS, et al. Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease. Ann Neurol. 2004 Jul;56(1):149-62.

  [5]. Rideout HJ, et al. Dopaminergic neurons in rat ventral midbrain cultures undergo selective apoptosis and form inclusions, but do not up-regulate iHSP70, following proteasomal inhibition. J Neurochem. 2005 Jun;93(5):1304-13.

安全

• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 危险品运输编码: NONH for all modes of transport