1538-09-6

• 常用中文名：苄星青霉素
• 常用英文名：Penicillin G benzathine
• CAS号：1538-09-6
• 分子式：C₄₈H₅₆N₆O₈S₂
• 分子量：909.124
• 相关类别： 原料药 抗生素类药物 青霉素类药
• 发布时间：2018-02-05 08:00:00
• 更新时间：2024-01-02 20:53:39
• Penicillin G benzathine (Benzathine benzylpenicillin) 是一种能抗多种细菌感染的抗生素。

名称

• 中文名: 苄星青霉素 G
• 英文名: benzylpenicillin benzathine
• 中文别名: 苄青霉素; 苄星青霉素G; (2S,5R,6R)-3,3-二甲基-6-(2-苯乙酰氨基)-7-氧代-4-硫杂-1-氮杂双环[3.2.0]庚烷-2-甲酸二苄基乙二胺; 苄星青霉素
• 英文别名: leomypen; neolin; dibencil; 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-, (2S,5R,6R)-, compd. with N,N-bis(phenylmethyl)-1,2-ethanediamine (2:1); benzathine benzylpenicillin; (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-[(phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid - N,N'-dibenzylethane-1,2-diamine (2:1); benzapen; moldamin; N,N'-Dibenzylethylenedi amine bis[benzylpenicillin]; Megacillin; pendepon; DBED-penicillin; Penicillin G N,N'-dibenzylethylenediamine salt; [2S-(2a,5a,6b)]-3,3-Dimethyl-7-oxo-6-[(phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid compd with N,N'-bis(phenylmethyl)-1,2-ethanediamine (2:1); cillenta; N,N'-Dibenzyl-1,2-ethanediaminium bis{(2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate}; penadur; Benzathine Penicillin G; bicillin; longicil

物化性质

• 沸点: 663.3ºCat 760 mmHg
• 熔点: 123-124ºC
• 分子式: C₄₈H₅₆N₆O₈S₂
• 分子量: 909.124
• 闪点: 355ºC
• 精确质量: 908.360107
• PSA: 248.08000
• LogP: 5.72700
• 蒸汽压: 1.69E-18mmHg at 25°C
• 储存条件: 通风低温干燥

生物活性

• 描述: Penicillin G benzathine (Benzathine benzylpenicillin) 是一种能抗多种细菌感染的抗生素。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 参考文献:

  [1]. Bowen AC, et al. Short-course oral co-trimoxazole versus intramuscular benzathine benzylpenicillin for impetigo in a highly endemic region: an open-label, randomised, controlled, non-inferiority trial. Lancet. 2014 Dec 13;384(9960):2132-40.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : XH9425000 CAS REGISTRY NUMBER : 1538-09-6 LAST UPDATED : 199707 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C32-H36-N4-O8-S2.C16-H20-N2 MOLECULAR WEIGHT : 909.22 WISWESSER LINE NOTATION : T45 ANV ESTJ CMV1R& F F GVQ & 2 &622 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,774,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 460 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Lungs, Thorax, or Respiration - dyspnea REFERENCE : ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 4,633,1954 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Parenteral DOSE : 22905 ug/kg SEX/DURATION : female 4 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) REFERENCE : BEXBAN Bulletin of Experimental Biology and Medicine (English Translation). Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.41- 1956- Volume(issue)/page/year: 82,1076,1976 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - T1268 No. of Facilities: 49 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1896 (estimated) No. of Female Employees: 921 (estimated)

安全

• 符号: GHS07, GHS08
• 信号词: Danger
• 危害声明: H302-H334
• 警示性声明: P261-P342 + P311
• 个人防护装备: dust mask type N95 (US);Eyeshields;Faceshields;Gloves
• 危害码 (欧洲): Xn: Harmful;
• 风险声明 (欧洲): R22
• 安全声明 (欧洲): 36
• 危险品运输编码: NONH for all modes of transport
• RTECS号: XH9425000