103909-75-7

• 常用中文名：马沙骨化醇
• 常用英文名：Maxacalcitol
• CAS号：103909-75-7
• 分子式：C₂₆H₄₂O₄
• 分子量：418.609
• 相关类别： 信号通路 维生素 D 相关 VD/VDR
• 发布时间：2018-06-13 18:16:16
• 更新时间：2026-07-15 20:15:41
• Maxacalcitol (22-Oxacalcitriol)是维生素D3类似物。

名称

• 中文名: 马沙骨化醇
• 英文名: (1R,3S,5Z)-5-[(2E)-2-[(1S,3aS,7aS)-1-[(1S)-1-(3-hydroxy-3-methylbutoxy)ethyl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
• 中文别名: 马沙骨化醇/MAXACALCITOL; 22-氧卡利醇; 马沙骨化醇/玛莎骨化醇; 玛莎骨化醇; 氘6-麦角钙化醇; 马沙骨化醇,10 MM DMSO 溶液; (1R,3S,Z)-5-((E)-2-((1S,3AS,7AS)-1-((S)-1-(3-羟基-3-甲基丁氧基)乙基)-7A-甲基六氢-1H-茚-4(2H)-亚基)亚乙基)-4-亚甲基环己烷-1,3-二醇; Maxacalcitol试剂
• 英文别名: Oxarol; (1R,3S,Z)-5-((E)-2-((1S,3aS,7aS)-1-((S)-1-(3-Hydroxy-3-methylbutoxy)ethyl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol; 1α,25-Dihydroxy-22-oxavitamin D3; (1S,3R,5Z,7E,9ξ)-20-(3-hydroxy-3-methylbutoxy)-9,10-secopregna-5,7,10-triene-1,3-diol; 1,25-dihydroxy-22-oxavitamin D3; (1S,3R,5Z,7E,9ξ,20S)-20-(3-Hydroxy-3-methylbutoxy)-9,10-secopregna-5,7,10-triene-1,3-diol; Prezios; Maxacalcitol (22-Oxacalcitriol); 22-Oxa-1,25-dihydroxyvitamin D3; (1R,3S,Z)-5-(2-((1S,3aS,7aS,E)-1-((S)-1-(3-hydroxy-3-methylbutoxy)ethyl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol; Maxacalcitol, 10 mM in DMSO; Mashacalcitol/Mashacalcitol; 1a,25-Dihydroxy-22-oxavitamin D3; Macalciferol; MAXACALCITOL; (1R,3S,5Z)-4-Methylene-5-[(2E)-2-[(1S,3aS,7aS)-octahydro-1-[(1S)-1-(3-hydroxy-3-methylbutoxy)ethyl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol; (1S,3R,5Z,7E,20S)-20-(3-hydroxy-3-methylbutoxy)-9,10-secopregna-5,7,10-triene-1,3-diol; 22-Oxa-1α,25-dihydroxycholecalciferol; MC 1275; (5Z,7E)-9,10-Seco-22-oxacholesta-5,7,10-triene-1α,3β,25-triol; 1,3-Cyclohexanediol, 4-methylene-5-[(2E)-2-[(1S,3aS,7aS)-octahydro-1-[(1S)-1-(3-hydroxy-3-methylbutoxy)ethyl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-, (1R,3S,5Z); 22-Oxacalcitriol; Oxacalcitriol; (+)-(5Z,7E)-(1S,3R,20S)-20-(3-Hydroxy-3-methylbutyloxy)-9,10-secopregna-5,7,10-triene-1,3-diol; (1S-(1a(R*),3ab,4E(1S*,3R*,5Z),7aa))-4-Methylene-5-(2-(octahydro-1-(1-(3-hydroxy-3-methylbutoxy)ethyl)-7a-methyl-4H-inden-4-ylidene)ethylidene)-1,3-cyclohexanediol; 1alpha,25-Dihydroxy-22-oxavitamin D3; 1R,25-dihydroxy-22-oxavitamin D3; 4-methylene-5Z-[2E-[(3aS)-octahydro-1S-[1S-(3-hydroxy-3-methylbutoxy)ethyl]-7aS-methyl-4H-inden-4-ylidene]ethylidene]-1R,3S-cyclohexanediol; D6-Maxacalcitol

物化性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 581.4±50.0 °C at 760 mmHg
• 分子式: C₂₆H₄₂O₄
• 分子量: 418.609
• 闪点: 305.4±30.1 °C
• 精确质量: 418.308319
• PSA: 69.92000
• LogP: 4.38
• 蒸汽压: 0.0±3.7 mmHg at 25°C
• 折射率: 1.549
• 储存条件: 2-8℃

生物活性

• 描述: Maxacalcitol (22-Oxacalcitriol)是维生素D3类似物。
• 相关类别:
  信号通路 >> 维生素 D 相关 >> VD/VDR
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Barroga, et al. Inhibitory effects of 22-oxa-calcitriol and all-trans retinoic acid on the growth of a canine osteosarcoma derived cell-line in vivo and its pulmonary metastasis in vivo. Res.Vet.Sci. (2000)68 79.

  [2]. Monier-Faugere, et al. 22-Oxacalcitriol suppresses secondary hyperparathyroidism without inducing low bone turnover in dogs with renal failure. Kidney Int. (1999)55 821.

  [3]. Inoue K, et al. Maxacalcitol ameliorates tubulointerstitial fibrosis in obstructed kidneys by recruiting PPM1A/VDR complex to pSmad3.Lab Invest. 2012 Aug 27.

  [4]. Karashima T, et al. Successful Treatment of Bowen's Disease with Topical Maxacalcitol.Acta Derm Venereol. 2012 Jan 26.

合成路线

上下游产品

上游产品  7
917-54-4 413571-27-4 20998-18-9 111594-61-7
81522-68-1 192573-35-6 413571-28-5
下游产品  0