马沙骨化醇

• 常用名: 马沙骨化醇
• 英文名: Maxacalcitol
• CAS号: 103909-75-7
• 分子量: 418.609
• 密度: 1.1±0.1 g/cm3
• 沸点: 581.4±50.0 °C at 760 mmHg
• 分子式: C₂₆H₄₂O₄
• 熔点: N/A
• 闪点: 305.4±30.1 °C

马沙骨化醇用途

Maxacalcitol (22-Oxacalcitriol)是维生素D3类似物。

马沙骨化醇名称

• 中文名: 马沙骨化醇
• 英文名: (1R,3S,5Z)-5-[(2E)-2-[(1S,3aS,7aS)-1-[(1S)-1-(3-hydroxy-3-methylbutoxy)ethyl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol

马沙骨化醇生物活性

• 描述: Maxacalcitol (22-Oxacalcitriol)是维生素D3类似物。
• 相关类别:
  信号通路 >> 维生素 D 相关 >> VD/VDR
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Barroga, et al. Inhibitory effects of 22-oxa-calcitriol and all-trans retinoic acid on the growth of a canine osteosarcoma derived cell-line in vivo and its pulmonary metastasis in vivo. Res.Vet.Sci. (2000)68 79.

  [2]. Monier-Faugere, et al. 22-Oxacalcitriol suppresses secondary hyperparathyroidism without inducing low bone turnover in dogs with renal failure. Kidney Int. (1999)55 821.

  [3]. Inoue K, et al. Maxacalcitol ameliorates tubulointerstitial fibrosis in obstructed kidneys by recruiting PPM1A/VDR complex to pSmad3.Lab Invest. 2012 Aug 27.

  [4]. Karashima T, et al. Successful Treatment of Bowen's Disease with Topical Maxacalcitol.Acta Derm Venereol. 2012 Jan 26.

马沙骨化醇物理化学性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 581.4±50.0 °C at 760 mmHg
• 分子式: C₂₆H₄₂O₄
• 分子量: 418.609
• 闪点: 305.4±30.1 °C
• 精确质量: 418.308319
• PSA: 69.92000
• LogP: 4.38
• InChIKey: DTXXSJZBSTYZKE-WVLVMWKDSA-N
• SMILES: C=C1C(=CC=C2CCCC3(C)C2CCC3C(C)OCCC(C)(C)O)CC(O)CC1O
• 蒸汽压: 0.0±3.7 mmHg at 25°C
• 折射率: 1.549
• 储存条件: 2-8℃

马沙骨化醇靶点实验

查看更多实验

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Binding affinity for human vitamin D binding protein (hDBP) relative to 1,25(OH)2D3 (... 来源：ChEMBL 靶标：Vitamin D-binding protein External Id：CHEMBL823904

实验名称：Antiviral activity against SARS-CoV-2 (USA-WA1/2020 strain) measured by imaging in HR... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303810

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808149

实验名称：Enzymatic assay of human HDAC6 with custom peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808150

实验名称：Rat Vitamin D receptor (1I. Vitamin D receptor-like receptors) 来源：IUPHAR-DB 靶标：Vitamin D receptor (1I. Vitamin D receptor-like receptors) [Rattus norvegicus] External Id：605_Rat

实验名称：Stability in rat liver microsome relative to maxacalcitol 来源：ChEMBL 靶标：Liver microsomes External Id：CHEMBL861164

实验名称：Calcemic activity in percutaneously dosed mouse relative to control 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL861165

实验名称：Antiproliferative activity against human keratinocyte assessed as inhibition of [3H]T... 来源：ChEMBL 靶标：Keratinocyte External Id：CHEMBL859970

实验名称：Antiproliferative activity against human keratinocyte assessed as inhibition of [3H]T... 来源：ChEMBL 靶标：Keratinocyte External Id：CHEMBL859971

共28条，当前第1页，共3页

1

2

3

马沙骨化醇英文别名

• Oxarol
• (1R,3S,5Z)-4-Methylene-5-[(2E)-2-[(1S,3aS,7aS)-octahydro-1-[(1S)-1-(3-hydroxy-3-methylbutoxy)ethyl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol
• (1S,3R,5Z,7E,20S)-20-(3-hydroxy-3-methylbutoxy)-9,10-secopregna-5,7,10-triene-1,3-diol
• 1α,25-Dihydroxy-22-oxavitamin D3
• MC 1275
• Maxacalcitol
• (1S,3R,5Z,7E,9ξ)-20-(3-hydroxy-3-methylbutoxy)-9,10-secopregna-5,7,10-triene-1,3-diol
• 1,25-dihydroxy-22-oxavitamin D3
• 22-Oxacalcitriol
• (1S,3R,5Z,7E,9ξ,20S)-20-(3-Hydroxy-3-methylbutoxy)-9,10-secopregna-5,7,10-triene-1,3-diol
• Prezios
• (1S-(1a(R*),3ab,4E(1S*,3R*,5Z),7aa))-4-Methylene-5-(2-(octahydro-1-(1-(3-hydroxy-3-methylbutoxy)ethyl)-7a-methyl-4H-inden-4-ylidene)ethylidene)-1,3-cyclohexanediol
• 22-Oxa-1,25-dihydroxyvitamin D3
• 1alpha,25-Dihydroxy-22-oxavitamin D3
• 1R,25-dihydroxy-22-oxavitamin D3
• 1a,25-Dihydroxy-22-oxavitamin D3