141064-23-5

• 常用中文名：诺美林草酸盐
• 常用英文名：Xanomeline oxalate
• CAS号：141064-23-5
• 分子式：C₁₆H₂₅N₃O₅S
• 分子量：371.452
• 相关类别： 信号通路 G 蛋白偶联受体/G 蛋白 由mAChR
• 发布时间：2017-11-28 19:10:09
• 更新时间：2026-07-11 18:46:14
• Xanomeline(LY246708)是M1毒蕈碱受体激动剂。

名称

• 中文名: 诺美林草酸盐
• 英文名: 3-hexoxy-4-(1-methyl-3,6-dihydro-2H-pyridin-5-yl)-1,2,5-thiadiazole,oxalic acid
• 中文别名: 诺美林草酸盐,10 MM DMSO 溶液; XANOMELINE OXALATE,M1 MUSCINIC ACETYLCHOLINE RECTOR激动剂; 3-(己基氧基)-4-(1-甲基-1,2,5,6-四氢吡啶-3-基)-1,2,5-噻二唑草酸盐; 草酸占诺美林; 呫诺美林草酸盐; 占诺美林 草酸盐; XANOMELINE OXALATE 诺美林草酸盐; Xanomeline oxalate试剂; XANOMELINE OXALATE,M1 MUSCINIC ACETYLCHOLINE RECTOR激动剂(DMSO SOLUTION)
• 英文别名: Xanomeline oxalate salt; Lumeron; Xanomeline oxalate, M1 muscinic acetylcholine rector agonist (DMSO solution); 5-[4-(Hexyloxy)-1,2,5-thiadiazol-3-yl]-1-methyl-1,2,3,6-tetrahydropyridine ethanedioate (1:1); LY246708;MEMCOR;LUMERON; Xanomeline (oxalate); Xanomeline oxalate, 10 mM in DMSO; xanomeline oxalate; 3-(3-Hexyloxy-1,2,5-thiadiazol-4-yl)-1,2,5,6-tetrahydro-1-methylpyridine oxalate; Xanomeline oxalate, M1 muscinic acetylcholine rector agonist; LY246708 oxalate; Pyridine, 3-[4-(hexyloxy)-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahydro-1-methyl-, ethanedioate (1:1); 3-[4-(Hexyloxy)-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahydro-1-methylpyridine ethanedioate (1:1); 3-(Hexyloxy)-4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)-1,2,5-thiadiazole oxalate; Xanomeline oxalate (LY246708; unii-jf5a0pk3g5; 3-[4-(Hexyloxy)-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahydro-1-methylpyridineoxalate

物化性质

• 分子式: C₁₆H₂₅N₃O₅S
• 分子量: 371.452
• 精确质量: 371.151489
• PSA: 141.09000
• LogP: 2.30960
• 储存条件: 2-8℃

生物活性

• 描述: Xanomeline(LY246708)是M1毒蕈碱受体激动剂。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 由mAChR
  信号通路 >> 神经信号通路 >> mAChR
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Shannon HE, et al. Xanomeline: a novel muscarinic receptor agonist with functional selectivity for M1 receptors. J Pharmacol Exp Ther. 1994 Apr;269(1):271-81.

  [2]. Bymaster FP, et al. Neurochemical effects of the M1 muscarinic agonist xanomeline (LY246708/NNC11-0232).J Pharmacol Exp Ther. 1994 Apr;269(1):282-9.

合成路线

131988-19-7 ~% 141064-23-5

文献：Novo Nordisk A/S Patent: US5545638 A1, 1996 ; US 5545638 A Title/Abstract Full Text Show Details Novo Nordisk A/S Patent: US5750541 A1, 1998 ; US 5750541 A

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