2752-64-9

• 常用中文名：新乌头碱； 中乌头碱
• 常用英文名：Mesaconitine
• CAS号：2752-64-9
• 分子式：C₃₃H₄₅NO₁₁
• 分子量：631.711
• 相关类别： 生物化工 中草药成分
• 发布时间：2018-04-22 08:00:00
• 更新时间：2026-07-03 17:43:50
• 新乌头碱(Mesaconitine)是乌头属植物的主要活性成分，具有多种药学作用。

名称

• 中文名: 中乌头碱
• 英文名: Mesaconitine
• 中文别名: 新乌头碱(对照品); 新乌碱,10 MM DMSO 溶液; 新乌头碱溶液, 100PPM; 新乌头碱, 来源于川乌; (3R,4R,6S,6AS,7R,7,8R,9R,10S,11S,11,12R,12,13R,14S)-11A-乙酰氧基-4,9,11-三羟基-6,10,13-三甲氧基-3-(甲氧基甲基)-1-甲基十四氢-1H-3,6A,12-IETHANE[1,1,2]三基)-7,9-甲桥萘并[2,3-B]氮杂环辛烷-8-基 苯甲酸酯; 乙腈中新乌头碱标准溶液; MESACONITINE/需提供证明; 新乌头碱(美沙乌头碱,新乌碱,中乌头碱,中乌碱); 新乌碱; 新乌头碱/HPLC; (3R,4R,6S,7R,7,8R,9R,10S,11S,11,13R,14S)-11A-乙酰氧基-4,9,11-三羟基-6,10,13-三甲氧基-3-(甲氧基甲基)-1-甲基十四氢-1H-3,6A,12-IETHANE[1,1,2]三基)-7,9-甲桥萘并[2,3-B]偶氮辛烷-8-基 苯甲酸酯; 新乌头碱; MESACONITINE 新乌头碱; 美沙乌头碱; 新乌头碱(中乌头碱; XWTJ对照品; 新乌头碱Mesaconitine; 中乌碱; 中间皂碱; 对照品/MESACONITINE/需提供证明; 中乌头碱/新乌头碱; 新乌头碱(标准品)
• 英文别名: 13,14,15-pentol,1,6,16-trimethoxy-4-(methoxymethyl)-20-methyl-aconitane-8; Mesaconitine //BP; MESACONITINE (PRIMARY STANDARD); Mesaconitine in methanol; (1-alpha,3-alpha,6-alpha,14-alpha,15-alpha,16-beta)-8-acetate14-benzoat; (1a,3a,6a,14a,15a,16β)-1,6,16-Trimethoxy-4-(methoxymethyl)-20-methyl-aconitane-3,8,13,14,15-pentol 8-acetate 14-benzoate; 1α,6α,16β-Trimethoxy-4-methoxymethyl-20-methylaconitane-3α,8,13,14α,15α-pentol 8-acetate 14-benzoate; MESACONITINE, (PRIMY STANDD); (3R,4R,6S,6aS,7R,7,8R,9R,10S,11S,11,12R,12,13R,14S)-11a-Acetoxy-4,9,11-trihydroxy-6,10,13-trimethoxy-3-(methoxymethyl)-1-methyltetradecahydro-2H-3,6a,12-iethane[1,1,2]triyl)-7,9-methanonaphtho[2,3-b]azocin-8-yl benzoate; Aconitane-3,8,13,14,15-pentol, 1,6,16-trimethoxy-4-(methoxymethyl)-20-methyl-, 8-acetate 14-benzoate, (1alpha,3alpha,6alpha,14alpha,15alpha,16beta); (1α,3α,6α,14α,15α,16β)-1,6,16-TriMethoxy-4-(MethoxyMethyl)-20-Methyl-aconitane-3,8,13,14,15-pentol 8-Acetate 14-Benzoate; MESACONITINE(AS); 4-(Methoxymethyl)-20-methyl-1α,6α,16β-trimethoxyaconitane-3α,8,13,14α,15α-pentol 8-acetate 14-benzoate; Mesaconitine, 10 mM in DMSO; Mesaconitine Solution, 100ppm; N-Desethyl-N-Methylaconitine; MESACONITINE(SH); Japaconitine B; Japaconitine A; Aconitane-3,8,13,14,15-pentol, 1,6,16-trimethoxy-4-(methoxymethyl)-20-methyl-, 8-acetate 14-benzoate, (1α,3α,6α,14α,15α,16β); Aconitane-3,8,13,14,15-pentol, 1,6,16-trimethoxy-4-(methoxym; Mesaaconitine; Aconitane-3,8,13,14,16-pentol, 1,6,15-trimethoxy-4-(methoxymethyl)-20-methyl-, 8-acetate 14-benzoate; MESACONITINE; 8-Acetoxy-3,13,16-trihydroxy-1,6,15-trimethoxy-4-(methoxymethyl)-20-methylaconitan-14-yl benzoate; Mesaconitine from Aconitum cmichaeli Debeaux

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 695.0±55.0 °C at 760 mmHg
• 分子式: C₃₃H₄₅NO₁₁
• 分子量: 631.711
• 闪点: 374.1±31.5 °C
• 精确质量: 631.299255
• PSA: 153.45000
• LogP: 0.27
• 外观性状: 固体;White to Light yellow powder to crystal
• 蒸汽压: 0.0±2.3 mmHg at 25°C
• 折射率: 1.618
• 储存条件: 库房低温,通风,干燥,与食品原料分开存放

生物活性

• 描述: 新乌头碱(Mesaconitine)是乌头属植物的主要活性成分,具有多种药学作用。
• 相关类别:
  信号通路 >> 细胞凋亡 >> TNF受体
  天然产物 >> 生物碱
  研究领域 >> 其他
• 参考文献:

  [1]. Ogura J, et al. Mesaconitine-induced relaxation in rat aorta: role of Na+/Ca2+ exchangers in endothelial cells. Eur J Pharmacol. 2004 Jan 12;483(2-3):139-46.

  [2]. Mitamura M, et al. Mesaconitine-induced relaxation in rat aorta: involvement of Ca2+ influx and nitric-oxide synthase in the endothelium. Eur J Pharmacol. 2002 Feb 2;436(3):217-25.

  [3]. Murayama M, et al. Mechanism of analgesic action of mesaconitine. I. Relationship between analgesic effect and central monoamines or opiate receptors. Eur J Pharmacol. 1984 May 18;101(1-2):29-36.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : AR5563000 CHEMICAL NAME : Aconitane-3,8,13,14,15-pentol, 1,6,16-trimethoxy-4-(methoxymethyl)-20-methyl-, 8-acetate 14-benzoate, (1-alpha,3-alpha,6-alpha,14-alpha,15-alpha,16-beta)- CAS REGISTRY NUMBER : 2752-64-9 LAST UPDATED : 199009 DATA ITEMS CITED : 7 MOLECULAR FORMULA : C33-H45-N-O11 MOLECULAR WEIGHT : 631.79 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1900 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JJTOEX Japanese Journal of Toxicology. (Yakugyo Jihosha, Hokushin Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo, 101, Japan) V.1- 1988- Volume(issue)/page/year: 2,225,1989 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 213 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 97,359,1977 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 204 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JJTOEX Japanese Journal of Toxicology. (Yakugyo Jihosha, Hokushin Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo, 101, Japan) V.1- 1988- Volume(issue)/page/year: 2,225,1989 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 100 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JJTOEX Japanese Journal of Toxicology. (Yakugyo Jihosha, Hokushin Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo, 101, Japan) V.1- 1988- Volume(issue)/page/year: 2,225,1989 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Mammal - cat DOSE/DURATION : 80 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 23,873,1981 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 100 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 23,873,1981 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 40 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 23,873,1981

安全

• 符号: GHS06
• 信号词: Danger
• 危害声明: H300 + H330
• 警示性声明: P260-P264-P284-P301 + P310-P310
• 危害码 (欧洲): Xn
• 安全声明 (欧洲): 24/25
• 危险品运输编码: UN 1544
• 包装等级: I
• 危险类别: 6.1(a)

合成路线

3327-35-3 74-88-4 ~88% 2752-64-9

文献：Kulanthaivel, Palaniappan; Pelletier, S. William Tetrahedron, 1988 , vol. 44, # 14 p. 4313 - 4320

302-27-2 ~% 2752-64-9

文献：Kulanthaivel, Palaniappan; Pelletier, S. William Tetrahedron, 1988 , vol. 44, # 14 p. 4313 - 4320

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