6933-90-0

• 常用中文名：盐酸氯丙那林
• 常用英文名：Clorprenaline hydrochloride
• CAS号：6933-90-0
• 分子式：C₁₁H₁₇Cl₂NO
• 分子量：268.180
• 相关类别： 原料药 呼吸系统用药 平喘药
• 发布时间：2018-03-16 08:00:00
• 更新时间：2024-01-02 20:17:14
• 用于治疗支气管哮喘

名称

• 中文名: 盐酸氯丙那林
• 英文名: 1-(2-Chlorophenyl)-2-(isopropylamino)ethanol hydrochloride
• 中文别名: alpha-[(1-甲基乙基)氨基]甲基-2-氯-苯甲醇盐酸盐; 甲醇中氯丙那林; 氯丙那林; 盐酸氯喘
• 英文别名: 1-(2-chlorophenyl)-2-(propan-2-ylamino)ethanol,hydrochloride; 1-(2-Chlorophenyl)-2-(isopropylamino)ethanol hydrochloride hydrate; 2-Chloro-a-(((1-methylethyl)amino)methyl)benzenemethanol Hydrochloride Monohydrate; Clorprenaline hydrochloride anhydrous; Benzenemethanol, 2-chloro-α-[[(1-methylethyl)amino]methyl]-, hydrochloride, hydrate (1:1:1); Clorprenaline hydrochloride

物化性质

• 沸点: 329.7ºC at 760 mmHg
• 熔点: 165-169ºC
• 分子式: C₁₁H₁₇Cl₂NO
• 分子量: 268.180
• 闪点: 153.2ºC
• 精确质量: 267.079285
• PSA: 32.26000
• LogP: 3.56430
• 储存条件: 室温

生物活性

• 描述: Clorprenaline hydrochloride 是一种 β2-肾上腺素受体 (β2-adrenergic receptor) 激动剂。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体
  研究领域 >> 炎症/免疫
• 靶点:

  β2-adrenergic receptor[1]

• 参考文献:

  [1]. Shao X, et al. Preparation of Fe2O3-Clorprenaline/Tetraphenylborate Nanospheres and Their Application as Ion Selective Electrode for Determination of Clorprenaline in Pork. Nanoscale Res Lett. 2016 Dec;11(1):178.

  [2]. Shen S, et al. Determination of beta2-agonists by ion chromatography with direct conductivity detection. J Pharm Biomed Anal. 2005 Jun 1;38(1):166-72.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : DN9450000 CHEMICAL NAME : Benzyl alcohol, o-chloro-alpha-((isopropylamino)methyl)-, hydrochloride CAS REGISTRY NUMBER : 6933-90-0 LAST UPDATED : 199806 DATA ITEMS CITED : 8 MOLECULAR FORMULA : C11-H16-Cl-N-O.Cl-H MOLECULAR WEIGHT : 250.19 WISWESSER LINE NOTATION : GR BYQ1MY1&1 &GH HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 445 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,438,1995 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 550 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - cyanosis REFERENCE : NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 65,93,1969 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 100 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 293 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - cyanosis REFERENCE : NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 65,93,1969 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 61 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - cyanosis REFERENCE : NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 65,93,1969 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : >400 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,438,1995 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 50 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis REFERENCE : NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 65,93,1969 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1550 mg/kg/31D-I TOXIC EFFECTS : Cardiac - changes in heart weight Lungs, Thorax, or Respiration - changes in lung weight Related to Chronic Data - death REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 13,469,1977

安全

• 危害码 (欧洲): Xi
• 海关编码: 2942000000

海关

海关编码	2922199090
中文概述	2922199090. 其他氨基醇及其醚，酯和它们的盐（但含一种以上含氧基的除外）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
Summary	2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%