179068-02-1

• 常用中文名：PHCCC
• 常用英文名：PHCCC
• CAS号：179068-02-1
• 分子式：C₁₇H₁₄N₂O₃
• 分子量：294.305
• 相关类别： 研究领域 癌症
• 发布时间：2018-06-06 00:30:29
• 更新时间：2024-01-02 19:26:15
• PHCCC是Group I metabotropic glutamate receptor拮抗剂,EC50是6 uM。

名称

• 中文名: PHCCC
• 英文名: (7E)-7-(Hydroxyimino)-N-phenyl-7,7a-dihydrocyclopropa[b]chromene-1a(1H)-carboxamide
• 英文别名: (7E)-7-(Hydroxyimino)-N-phenyl-7,7a-dihydrocyclopropa[b]chromene-1a(1H)-carboxamide; Cyclopropa[b][1]benzopyran-1a(1H)-carboxamide, 7,7a-dihydro-7-(hydroxyimino)-N-phenyl-, (7E)-; PHCCC

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 579.1±50.0 °C at 760 mmHg
• 分子式: C₁₇H₁₄N₂O₃
• 分子量: 294.305
• 闪点: 304.0±30.1 °C
• 精确质量: 294.100433
• LogP: 1.88
• 蒸汽压: 0.0±1.7 mmHg at 25°C
• 折射率: 1.700
• 储存条件: 2-8℃

生物活性

• 描述: PHCCC是Group I metabotropic glutamate receptor拮抗剂,EC50是6 uM。
• 相关类别:
  研究领域 >> 癌症
• 参考文献:

  [1]. Marino MJ et al. Allosteric modulation of group III metabotropic glutamate receptor 4: a potential approach to Parkinson's disease treatment. Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13668-73.

  [2]. Maj M et al. (-)-PHCCC, a positive allosteric modulator of mGluR4: characterization, mechanism of action, and neuroprotection. Neuropharmacology. 2003 Dec;45(7):895-906.

  [3]. Szczurowska E et al. Positive allosteric modulator of mGluR4 PHCCC exhibits proconvulsant action in three models of epileptic seizures in immature rats. Physiol Res. 2012;61(6):619-28.

  [4]. Domin H et al. Neuroprotective potential of the group III mGlu receptor agonist ACPT-I in animal models of ischemic stroke: In vitro and in vivo studies. Neuropharmacology. 2016 Mar;102:276-94.

安全

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302
• 警示性声明: P301 + P312 + P330
• 危险品运输编码: NONH for all modes of transport