1426214-51-8

• 常用中文名：SGK1 Inhibitor
• 常用英文名：SGK1 Inhibitor
• CAS号：1426214-51-8
• 分子式：C₁₇H₁₂Cl₂N₆O₂S
• 分子量：435.287
• 发布时间：2021-01-10 12:12:42
• 更新时间：2024-01-11 19:04:16
• SGK1 inhibitor is an inhibitor of serum- and glucocorticoid-regulated kinase 1 (SGK1) and SGK2. It is selective for SGK1 and SGK2 over SGK3 in the presence of a high concentration of ATP. SGK1 inhibitor prevents phosphorylation of GSK3β in U2OS cells and decreases cell viability in BYL719-insensitive HCC1954 cells when used in combination with the PI3Kα inhibitor BYL719. SGK1 inhibitor reduces tumor growth in an HCC1954 mouse xenograft model when administered in combination with BYL719.

名称

• 英文名: SGK1 Inhibitor
• 英文别名: N-[4-(3-Amino-1H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-2,3-dichlorobenzenesulfonamide; MFCD31615459; Benzenesulfonamide, N-[4-(3-amino-1H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-2,3-dichloro-; SGK1 Inhibitor

物化性质

• 密度: 1.7±0.1 g/cm3
• 沸点: 730.5±70.0 °C at 760 mmHg
• 分子式: C₁₇H₁₂Cl₂N₆O₂S
• 分子量: 435.287
• 闪点: 395.6±35.7 °C
• 精确质量: 434.011963
• LogP: 3.81
• 蒸汽压: 0.0±2.4 mmHg at 25°C
• 折射率: 1.750