208445-06-1

• 常用中文名：Rp-8-bromo-Cyclic GMPS sodium salt
• 常用英文名：Rp-8-Br-cGMPS
• CAS号：208445-06-1
• 分子式：C₁₀H₁₀BrN₅NaO₆PS
• 分子量：462.15
• 相关类别： 信号通路 跨膜转运 钙通道
• 发布时间：2021-05-12 16:03:53
• 更新时间：2024-07-19 12:10:42
• Rp-8-Br-cGMPS (Rp-8-bromo-Cyclic GMPS) sodium salt 是一种有效的 Ca2+-ATPase 激活剂。Rp-8-Br-cGMPS sodium salt 通过激活 Ca2+-ATP 酶并随后从细胞中去除 Ca2+ 来介导胞质 Ca2+ 减少。

名称

• 中文名: Rp-8-bromo-Cyclic GMPS sodium salt
• 英文名: Rp-8-bromo-Cyclic GMPS (sodium salt)
• 英文别名: Sodium (2R,4aR,6R,7R,7aS)-6-(2-amino-8-bromo-6-oxo-1,6-dihydro-9H-purin-9-yl)-7-hydroxytetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2-thiolate 2-oxide; Rp-8-Bromoguanosine- 3', 5'- cyclic monophosphorothioate sodium salt; Sodium (2R,4aR,6R,7R,7aS)-6-(2-amino-8-bromo-6-oxo-1,6-dihydro-9H-purin-9-yl)-7-hydroxytetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-2-olate 2-sulfide; Rp-8-Br-Cgmps; Sodium (4aR,6R,7R,7aS)-6-(2-amino-8-bromo-6-oxo-1,6-dihydro-9H-purin-9-yl)-7-hydroxytetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-2-olate 2-sulfide; 6H-Purin-6-one, 2-amino-8-bromo-1,9-dihydro-9-[(2R,4aR,6R,7R,7aS)-tetrahydro-2,7-dihydroxy-2-sulfido-4H-furo[3,2-d]-1,3,2-dioxaphosphorin-6-yl]-, sodium salt (1:1); Rp-8-Br-cGMPS sodium salt; MFCD04037242; Rp-8-Bromo-cGMPS sodium salt; Rp-8-bromo-Cyclic GMPS (sodium salt); 6H-Purin-6-one, 2-amino-8-bromo-1,9-dihydro-9-[(2R,4aR,6R,7R,7aS)-tetrahydro-7-hydroxy-2-mercapto-2-oxido-4H-furo[3,2-d]-1,3,2-dioxaphosphorin-6-yl]-, sodium salt (1:1); 6H-Purin-6-one, 2-amino-8-bromo-1,9-dihydro-9-[(4aR,6R,7R,7aS)-tetrahydro-2,7-dihydroxy-2-sulfido-4H-furo[3,2-d]-1,3,2-dioxaphosphorin-6-yl]-, sodium salt (1:1); 6H-Purin-6-one, 2-amino-8-bromo-1,9-dihydro-9-[(4aR,6R,7R,7aS)-tetrahydro-7-hydroxy-2-mercapto-2-oxido-4H-furo[3,2-d]-1,3,2-dioxaphosphorin-6-yl]-, sodium salt (1:1); Sodium (4aR,6R,7R,7aS)-6-(2-amino-8-bromo-6-oxo-1,6-dihydro-9H-purin-9-yl)-7-hydroxytetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2-thiolate 2-oxide

物化性质

• 分子式: C₁₀H₁₀BrN₅NaO₆PS
• 分子量: 462.15
• 精确质量: 460.917053
• 储存条件: -20°C，密闭，干燥

生物活性

• 描述: Rp-8-Br-cGMPS (Rp-8-bromo-Cyclic GMPS) sodium salt 是一种有效的 Ca2+-ATPase 激活剂。Rp-8-Br-cGMPS sodium salt 通过激活 Ca2+-ATP 酶并随后从细胞中去除 Ca2+ 来介导胞质 Ca2+ 减少。
• 相关类别:
  信号通路 >> 跨膜转运 >> 钙通道
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Rashatwar SS, et, al. Effects of 8-bromo-cGMP on Ca2+ levels in vascular smooth muscle cells: possible regulation of Ca2+-ATPase by cGMP-dependent protein kinase. Proc Natl Acad Sci U S A. 1987 Aug;84(16):5685-9.