165800-04-4

• 常用中文名：依哌唑胺
• 常用英文名：Eperezolid
• CAS号：165800-04-4
• 分子式：C₁₈H₂₃FN₄O₅
• 分子量：394.39700
• 相关类别： 信号通路 抗感染 细菌
• 发布时间：2018-12-31 20:18:19
• 更新时间：2024-01-05 21:42:09
• Eperezolid(PNU-100592)是恶唑烷酮类抗生素,有很好的体外抑制性。

名称

• 中文名: N-[[(5S)-3-[3-氟-4-[4-(2-羟基乙酰基)-1-哌嗪基]苯基]-2-氧代-5-噁唑烷基]甲基]-乙酰胺
• 英文名: N-[[(5S)-3-[3-fluoro-4-[4-(2-hydroxyacetyl)piperazin-1-yl]phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide
• 英文别名: Eperezolid

物化性质

• 密度: 1.37g/cm3
• 沸点: 701.2ºC at 760 mmHg
• 分子式: C₁₈H₂₃FN₄O₅
• 分子量: 394.39700
• 闪点: 377.9ºC
• 精确质量: 394.16500
• PSA: 102.42000
• LogP: 0.38670
• 蒸汽压: 1.22E-20mmHg at 25°C
• 折射率: 1.579
• 储存条件: 2-8℃

生物活性

• 描述: Eperezolid(PNU-100592)是恶唑烷酮类抗生素,有很好的体外抑制性。
• 相关类别:
  信号通路 >> 抗感染 >> 细菌
  研究领域 >> 感染
• 参考文献:

  [1]. Rybak MJ, et al. Comparative in vitro activities and postantibiotic effects of the oxazolidinone compounds eperezolid (PNU-100592) and linezolid (PNU-100766) versus vancomycin against Staphylococcus aureus, coagulase-negative staphylococci, Enterococcus f

  [2]. Lin AH, et al. The oxazolidinone eperezolid binds to the 50S ribosomal subunit and competes with binding of chloramphenicol and lincomycin. Antimicrob Agents Chemother. 1997 Oct;41(10):2127-31.

  [3]. Zhou CC, et al. 1H nuclear magnetic resonance study of oxazolidinone binding to bacterial ribosomes. Antimicrob Agents Chemother. 2002 Mar;46(3):625-9.

安全

• 海关编码: 2934999090

合成路线

174649-08-2 ~87% 165800-04-4

文献：Narina, Srinivasarao V.; Sudalai, Arumugam Tetrahedron Letters, 2006 , vol. 47, # 38 p. 6799 - 6802

183805-10-9 ~% 165800-04-4

文献：Schaus, Scott E.; Jacobsen, Eric N. Tetrahedron Letters, 1996 , vol. 37, # 44 p. 7937 - 7940

183905-31-9 ~% 165800-04-4

文献：Schaus, Scott E.; Jacobsen, Eric N. Tetrahedron Letters, 1996 , vol. 37, # 44 p. 7937 - 7940

239438-47-2 ~% 165800-04-4

文献：Lohray, Braj B.; Baskaran, Sundarababu; Rao, B. Srinivasa; Reddy, B. Yadi; Rao, I. Nageswara Tetrahedron Letters, 1999 , vol. 40, # 26 p. 4855 - 4856

239438-46-1 ~% 165800-04-4

文献：Lohray, Braj B.; Baskaran, Sundarababu; Rao, B. Srinivasa; Reddy, B. Yadi; Rao, I. Nageswara Tetrahedron Letters, 1999 , vol. 40, # 26 p. 4855 - 4856

239438-42-7 ~% 165800-04-4

文献：Lohray, Braj B.; Baskaran, Sundarababu; Rao, B. Srinivasa; Reddy, B. Yadi; Rao, I. Nageswara Tetrahedron Letters, 1999 , vol. 40, # 26 p. 4855 - 4856

507-09-5 239438-49-4 ~% 165800-04-4

文献：Lohray, Braj B.; Baskaran, Sundarababu; Rao, B. Srinivasa; Reddy, B. Yadi; Rao, I. Nageswara Tetrahedron Letters, 1999 , vol. 40, # 26 p. 4855 - 4856

上下游产品

上游产品  8
174649-08-2 183805-10-9 183905-31-9 239438-47-2
239438-46-1 239438-42-7 507-09-5 239438-49-4
下游产品  0

海关

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%