487-79-6

• 常用中文名：海藻酸(mM/ml)
• 常用英文名：Kainic acid
• CAS号：487-79-6
• 分子式：C₁₀H₁₅NO₄
• 分子量：213.230
• 相关类别： 研究领域 神经疾病
• 发布时间：2018-05-12 08:00:00
• 更新时间：2026-07-01 09:52:23
• Kainic acid 是 CNS 中兴奋性氨基酸受体亚型的有效激动剂。

名称

• 中文名: 红藻氨酸
• 英文名: kainic acid
• 中文别名: (2S,3S,4S)-3-(羧基甲基)-4-(丙-1-烯-2-基)吡咯烷-2-羧酸; 卡英酸; 化合物：Kainic acid; 海人草酸; Kainic acid（红藻氨酸；卡英酸）; KAINIC ACID (MM/ML),PROTOTYPIC KAINATE RECTOR激动剂; 紅藻胺酸; 鷓鴣菜酸; 红藻氨酸,10 MM DMSO 溶液; KAINIC ACID,PROTOTYPIC KAINATE RECTOR激动剂; 海藻酸(MM/ML); Kainic acid(红藻氨酸; ALPHA-红藻氨酸; 化合物:Kainic acid; KAINIC ACID(红藻氨酸,卡英酸); 红藻氨酸-Calbiochem
• 英文别名: [2S-(2A,3B,4B)]-2-CBOXY-4-(1-METHYLETHENYL)-3-PYRROLIDINEACETIC ACID; helminal; Hydroxy Cholesterol-d4 (Major); (3aα Diacetyloxy-chol-5-ene-24-cboxylic Acid Ethyl Ester; (2S,3S,4S)-3-(cboxymethyl)-4-prop-1-en-2-ylpyrrolidine-2-cboxylic acid; [2S-[1(S*),2α KAINIC ACID; Kainicaci; Kainic acid (mM/ml), Prototypic kainate rector agonist; )-4,5-oxy-13-ethyl-17-hydroxy-18,19-dinorpregn-20-yn-3-one; [3aS-(3aα KAINATE; KAINIC ACID SYNTHETIC; (2S,3S,4S)-2-Cboxy-4-isopropenylpyrrolidine-3-acetic acid; Tenacigenin B, 3-O-β 2-CBOXYL-3-CBOXYMETHYL-4-ISOPROPENYL PYRROLIDINE; (−)-Kainic Acid; 12-dihydroxyguaian-6,10-diene; C12819; (-)-A-KAINIC ACID; (2S,3S,4S)-Cboxy-4-(1-methylethenyl)-3-pyrrolidineaceticacid; Periplogenin 3-[O-β )]-4-[2-(2,5-Dihydroxyphenyl)ethyl]octahydro-1-hydroxy-7a-methyl-5H-inden-5-one; (3S,4S)-3-(Carboxymethyl)-4-isopropenyl-L-proline; )-3a,4,7,7a-Tetrahydro-4-hydroxy-1H-isoindole-1,3(2H)-dione; alpha-kainicacid; α-Kainic acid; Dihydroergocristine mesylate; 2-CBOXY-4-(1-METHYLETHENYL)-3-PYRROLIDINEACETIC ACID; Allopyranosyl-(1&rr; Hydroxy Cholesterol 4-Acetate; KAINIC ACID (OPIKA-1(TM)); 7-p-Toluenesulfonylhydrazide 3β 2-cboxy-4-isopropenyl-3-pyrrolidineaceticaci; 3-pyrrolidineaceticacid,2-cboxy-4-(1-methylethenyl)-,(2s-(2-alpha,3-beta; digenicacid; glucopyranosyl-(1&rr; smentopyranoside]; L-alpha-Kainic acid; (-)-α-Kainic Acid; (2-CBOXY-3-CBOXYMETHYL-4-ISOPROPENYLPYRROLIDINE); )-7-Dehydro-4,25-dihydroxycholesterol; 3-(cboxyMethyl)-4-prop-1-en-2-ylproline; Dihydroxy-chol-5-ene-24-cboxylic Acid Ethyl Ester; Dihydroxyandrost-5-en-17-one; digenin; oleandropyranosyl-11-O-isobutyryl-12-O-acetyl; Hydroxy Cholesterol-d7 4-Acetate; Kainic acid, 10 mM in DMSO; )-3,4-Dihydroxy-chol-5,7-diene-24-cboxylic Acid Methyl Ester; Kainic; Kainic acid, prototypic kainate rector agonist; 3-Pyrrolidineaceticacid, 2-cboxy-4-(1-methylethenyl)-, (2S,3S,4S); ]]-4-Methyl-1-(1-phenylethyl)-2-piperidinecboxylic Acid Ethyl Ester; 4-beta)); )]-Hexahydro-2-oxo-1,3-bis(phenylmethyl)-1H-Thieno[3,4-d]imidazole-4-pentanoic Acid Phenylmethyl Ester; (2S,3S,4R)-CBOXY-4-(1-METHYLETHENYL)-3-PYRROLIDINEACETIC ACID

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 439.9±45.0 °C at 760 mmHg
• 熔点: 253-254ºC
• 分子式: C₁₀H₁₅NO₄
• 分子量: 213.230
• 闪点: 219.8±28.7 °C
• 精确质量: 213.100113
• PSA: 86.63000
• LogP: 0.50
• 外观性状: 白色固体
• 蒸汽压: 0.0±2.3 mmHg at 25°C
• 折射率: 1.509
• 储存条件: 2-8℃

生物活性

• 描述: Kainic acid 是 CNS 中兴奋性氨基酸受体亚型的有效激动剂。
• 相关类别:
  信号通路 >> 其他 >> 其他
  天然产物 >> 酸和醛
  研究领域 >> 神经疾病
• 体内研究: 红藻氨酸是CNS中兴奋性氨基酸受体亚型的有效激动剂。在注射红藻氨酸后一天,三天和七天,HO-1水平显着增强。在注射红藻氨酸的icv后一天,HO-1蛋白水平达到最大值然后降低,但相对于注射媒介物的组仍然显着增强。 icv注射红藻氨酸后,HO-I免疫反应性不仅在CA3中强烈诱导,而且在整个海马中也广泛诱导[1]。
• 动物实验: 老鼠禁食过夜，可自由饮水。对于立体定位注射，将大鼠麻醉（戊巴比妥钠，50mg / kg，ip）并固定在Kopf立体定位框架中。根据大鼠脑图谱，将大鼠用2μL灭菌的生理盐水中的1μg红藻氨酸显微注射到右侧脑室，即距前囟0.2mm，右侧1.2mm，腹侧3.8mm。为了对照，给大鼠注射相同量（2μL）的载体，灭菌的生理盐水。每组中有5只大鼠用于本研究[1]。
• 参考文献:

  [1]. Matsuoka Y, et al. Kainic acid induction of heme oxygenase in vivo and in vitro. Neuroscience. 1998 Aug;85(4):1223-33.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UX9665250 CHEMICAL NAME : 3-Pyrrolidineacetic acid, 2-carboxy-4-isopropenyl- CAS REGISTRY NUMBER : 487-79-6 BEILSTEIN REFERENCE NO. : 0086660 LAST UPDATED : 199709 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C10-H15-N-O4 MOLECULAR WEIGHT : 213.26 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 32 mg/kg TOXIC EFFECTS : Brain and Coverings - other degenerative changes Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 3 mg/kg SEX/DURATION : female 14 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - behavioral TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 3 mg/kg SEX/DURATION : female 17-18 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - behavioral TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 3 mg/kg SEX/DURATION : female 19 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) MUTATION DATA TEST SYSTEM : Rodent - mouse DOSE/DURATION : 12 mg/kg REFERENCE : FOBGA8 Folia Biologica (Krakow). (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1953- Volume(issue)/page/year: 36,103,1988

安全

• 危害码 (欧洲): Xn
• 风险声明 (欧洲): R20/21/22
• 安全声明 (欧洲): 22-24/25-36
• RTECS号: UX9665250

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