32981-85-4

• 常用中文名：(2R,3S)-3-苯甲酰氨基-2-羟基-3-苯基丙酸甲酯
• 常用英文名：Bz-RS-iSer(3-Ph)-OMe
• CAS号：32981-85-4
• 分子式：C₁₇H₁₇NO₄
• 分子量：299.321
• 相关类别： 信号通路 抗感染 HIV
• 发布时间：2019-01-01 20:12:28
• 更新时间：2026-06-30 21:45:38
• Bz-RS-iSer(3-Ph)-OMe (compound 2) 是紫杉醇衍生物,在低细胞毒性下抑制 HSV 复制周期,阻断 Vero 细胞的有丝分裂,影响 M-MSV 诱导的肿瘤大小,并通过抑制 PHA 诱导的 T 淋巴细胞增殖而影响免疫应答。

名称

• 中文名: N-苯甲酰基-(2R,3S)-3-苯基异丝氨酸甲酯
• 英文名: methyl (2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoate
• 中文别名: (2R,3S)-甲基3-苯甲酰氨基-2-羟基-3-苯基丙酸酯; 紫杉醇杂质28; (2R,3S)-3-苯甲酰胺基-2-羟基-3-苯基丙酸甲酯; 紫杉醇杂质18; 甲基(2R,3S)- 3(苯甲氨基)-2-羟基-3-苯基丙酸酯; (2R,3S)-N-苄基-3-苯基异丝氨酸甲基酯; (2R,3S)-3-苯基异丝胺酸乙酯; (2R,35)-3-苯甲酰氨基2-羟基-3-苯基丙酸甲酯; 甲基 (2R,3S)-3-苯甲酰胺基-2-羟基-3-苯基丙酸酯; 2R.3S)-N-苯酰基-3-苯基异丝氨酸甲酯; 紫杉烷类侧链; (2R,3S)-N-苯甲酰基-3-苯基异丝氨酸甲酯; N-苯甲酰基-(2R,3S)-3-苯基异丝氨酸甲基酯; 甲基(2R,3S)-3-苯甲酰胺基-2-羟基-3-苯基丙酸酯; 紫杉醇侧链4; (2R,3S)-N-苯甲酰基-3-苯异丝胺酸甲酯; 3S)-3-苯甲酰氨基-2-羟基-3-苯基丙酸甲酯; 紫杉醇杂质11; (2R,3S)-3-苯甲酰氨基-2-羟基-3-苯基丙酸甲酯,紫杉醇侧链4; 紫杉酚侧链甲酯; 紫杉醇侧链4 (2R,3S)-3-苯甲酰氨基-2-羟基-3-苯基丙酸甲酯 N-苯甲酰基-(2R,3S)-3-苯基异丝氨酸甲酯; (2R,3S)-N-苯甲酰基-3-苯基异丝胺酸甲酯
• 英文别名: (2R,3S)-N-Benzoyl-3-phenylisoserine methyl ester, (2R,3S)-2-Hydroxy-3-N-benzoylamino-3-phenylmethyl propionate, ee; benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, methyl ester, (αR,βS); Paclitaxe Side Chain 4; PACLITAXE SIDE CHIAN 4; METHYL (2R,3S)-3-BENZAMIDO-2-HYDRO-3-PHENYLPROPIONATE; (2R,3S)-1-Benzoyl-2-Hydroxy-3-Aminophenylpionic Acid Ester; METHYL (2R,3S)-3-BENZAMIDO-2-HYDROXY-3-PHENYLPROPIONATE; Methyl (2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoate; (2R,3S)-N-benzoyl-3-PhenylisoserineMethylEster; Paclitaxel Impurity 18; Methyl (2R,3S)-N-Benzoyl-3-Phenylisoserine; N-BENZOYL-(2R,3S)-3-PHENYLISOSERINE METHYL ESTER; PaclitaxelSide Chian 4; Bz-RS-ISer(3-Ph)-Ome, 10 mM in DMSO; BENZYLOXYPHENYLISOSERINE METHYLESTER,N- (TAXOL SIDE CHAIN METHYLESTER)(SH); (2R,3S)-2-hydroxy-3-phenyl-3-(phenylformamido)propanoic acid; PACLITAXEL SIDE CHAIN 4; Methyl(2R,3S)-N-Benzoyl-3-Phenylisoserine; methyl(2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoate; Methyl(2R,3S)-3-benzamido-2-hydroxy-3-phenylpropionate; PACLITAXEL SIDE CHAIN NO 4; (2S,3S)-methyl 3-benzamido-2-hydroxy-3-phenylpropanoate; (2R,3S)-Methyl 3-benzaMido-2-hydroxy-3-phenylpropanoate; 2R,3S)-N-BENZOYLl-3-PHENYLISOSERINE METHYL ESTER; Methyl (2S,3S)-3-benzamido-2-hydroxy-3-phenyl-propanoate; Methyl (2R,3S)-N-benzoylphenylisoserinate; METHYL (2R) HYDROXY-(3S)-N-BENZOYLAMINO-3-PHENYL P; benzenepropanoicacid, b-(benzoylaMino)-a-hydroxy-, Methyl esterbS); C-13 SIDE CHAIN FOR PACLITAXEL II; Paclitaxel impurity 7/(2R,3S)-N-Benzoyl-3-phenyl Isoserine Methyl Ester; Paclitaxel Impurity 69; (2S,3S)-N-Benzoyl-3-phenylisoserine Methyl Ester; BENZYLOXYPHENYLISOSERINE METHYLESTER,N- (TAXOL SIDE CHAIN METHYLESTER)(P); N-Benzyloxyphenylisoserine Methylester; BENZYLOXYPHENYLISOSERINE METHYLESTER,N-(P); (2R,3S)-N-tert-butoxycbonyl 3-Phenylisoserine Methyl Este; 3-benzamido-3-(1-cyclohexa-2,4-dienyl)propanoic acid methyl ester; METHYL (2R,3S)-3-(BENZOYLAMINO)-2-HYDROXY-3-PHENYLPROPANOATE; (2R,3S)-3-phenylisoserine methyleste; (R)-methyl 2-hydroxy-3-(N-phenylbenzamido)propanoate; (2R, 3S) -3-benzoylamino-2-hydroxy-3-phenylpropionate methyl ester; Methyl(2R,3S)-3-(benzoylaMino)-2-hydroxy-3-phenylpropanoale; Methyl (2S,3S)-N-benzoyl-3-phenylisoserine; (2R，3S)-N-BENZOYLl-3-PHENYLISOSERINE METHYL ESTER (P); MFCD00673331; Paclitaxel Impurity 11

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 540.3±50.0 °C at 760 mmHg
• 分子式: C₁₇H₁₇NO₄
• 分子量: 299.321
• 闪点: 280.6±30.1 °C
• 精确质量: 299.115753
• PSA: 75.63000
• LogP: 2.90
• 外观性状: 白色晶体
• 蒸汽压: 0.0±1.5 mmHg at 25°C
• 折射率: 1.588
• 储存条件: -20℃

生物活性

• 描述: Bz-RS-iSer(3-Ph)-OMe (compound 2) 是紫杉醇衍生物,在低细胞毒性下抑制 HSV 复制周期,阻断 Vero 细胞的有丝分裂,影响 M-MSV 诱导的肿瘤大小,并通过抑制 PHA 诱导的 T 淋巴细胞增殖而影响免疫应答。
• 相关类别:
  信号通路 >> 抗感染 >> HIV
  研究领域 >> 感染
• 参考文献:

  [1]. Krawczyk E, et al. Cytotoxic, antiviral (in-vitro and in-vivo), immunomodulatory activity and influence on mitotic divisions of three taxol derivatives: 10-deacetyl-baccatin III, methyl (N-benzoyl-(2'R,3'S)-3'-phenylisoserinate) and N-benzoyl-(2'R,3'S)-3'-phenylisoserine. J Pharm Pharmacol. 2005;57(6):791‐797.

安全

• 海关编码: 2924299090

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海关

海关编码	2924299090
中文概述	2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 包装
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%