上海阿拉丁生化科技股份有限公司
上海市上海市浦东新区
产品名：去甲替林
纯度：98.0%
规格：100mg/50mg/5mg/25mg
联系人：阿拉丁

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上海化源世纪贸易有限公司
上海市上海市普陀区
产品名：去甲替林
纯度：98.0%
规格：
联系人：小陈

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联系电话：18916513247

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72-69-5生产厂家

72-69-5价格

72-69-5

72-69-5结构式

常用中文名：去甲替林
常用英文名：Nortriptyline
CAS号：72-69-5
分子式：C₁₉H₂₁N
分子量：263.37700
相关类别：原料药神经系统用药抗抑郁、躁狂药
发布时间：2018-05-18 08:00:00
更新时间：2026-07-04 19:30:31
去甲替林(去甲基阿米替林)是阿米替林的主要活性代谢产物,是一种用于缓解抑郁症症状的三环类抗抑郁药。去甲替林是一种有效的自噬抑制剂[1][2]。

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中文名	去甲替林
英文名	nortriptyline
中文别名	N-去甲基阿米替林去甲阿米替林去甲替林(盐酸去甲替林)检测标准品盐酸阿米替林C 盐酸去甲替林D3
英文别名	NORTRIPTYLINE //BP 3-(10,11-dihydro-5h-dibenzo[a,d]cyclohten-5-ylidene)-n-methylpropylamine Noritren Desmethylamitriptyline allegron Demethylamitriptyline 10,11-dihydro-n-methyl-5h-dibenzo(a,d)cyclohtene-delta(5,gamma)-propylamin Amitryptyline, demethyl Demethylamitriptylene Amitriptyline Impurity C Aventyl Psychostyl N-[3-(10,11-DIHYDRO-5H-DIBENZO[A,D]ANNULEN-5-YLIDENE)PROPYL]-N-METHYLAMINE HYDROCHLORIDE Ateben Nortriptylene Demethylamitryptyline Nortryptiline [14C]-Nortriptyline 5-(alpha-methylaminopropylidene)dibenzo[a,d]cyclohta[1,4]diene Desitriptilina nortryptyline 5-(3-Methylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cyclohtene NORTRIPTYLINE 10,11-dihydro-n-methyl-5h-dibenzo[a,d]cyclohtene-delta(5,gamma)-propylamine 5H-Dibenzo[a,d]cyclohtene-delta5,gamma-propylamine, 10,11-dihydro-N-methyl 10,11-dihydro-5-(3-methylaminopropylidene)-5h-dibenzo[a,d][1,4]cyclohtene 1-propanamine,3-(10,11-dihydro-5h-dibenzo(a,d)cyclohtene-5-ylidene)-n-methyl 1-Propanamine, 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohten-5-ylidene)-N-methyl Nortrityline 10,11-Dihydro-N-methyl-5H-dibenzo(a,d)cyclohtane-delta,gamma-propylamine desmethylamitriptyline lambeck C07274 3-(10,11-dihydro-5h-dibenzo[a,d]-cyclohten-5-ylidene)-n-methyl-1-propanamine c.3-(10,11-dihydro-5h-dibenzo[a,d]annulen-5-ylidene)-N-methylpropan-1-amine(nortriptyline) Noramitriptyline 5-[3-(Methylamino)propylidene]dibenzo[a,E]cyclohta[1,5]diene Avantyl Sesaval Lumbeck 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohten-5-ylidene)-N-methyl-1-propanamine noramitriptyline demethylamitryptylene 5-(3-(methylamino)propylidene)dibenzo(a,e)cyclohta(1,5)diene alleon EINECS 200-788-8 demethyl-amitryptylin 5h-dibenzo(a,d)cyclohtene-delta(5,gamma)-propylamine,10,11-dihydro-n-methyl 10,11-dihydro-5-(3-methylaminopropylidene)dibenzo(a,d)cyclohtene notriptyline

描述	去甲替林(去甲基阿米替林)是阿米替林的主要活性代谢产物,是一种用于缓解抑郁症症状的三环类抗抑郁药。去甲替林是一种有效的自噬抑制剂[1][2]。
相关类别	研究领域 >> 癌症信号通路 >> 自噬 >> 自噬研究领域 >> 神经疾病
参考文献	[1]. Dean L. Amitriptyline Therapy and CYP2D6 and CYP2C19 Genotype. In: Pratt VM, Scott SA, Pirmohamed M, et al., eds. Medical Genetics Summaries. Bethesda (MD): National Center for Biotechnology Information (US); March 23, 2017. [2]. Petrosyan E, et al. Repurposing Autophagy Regulators in Brain Tumors [published online ahead of print, 2022 Feb 18]. Int J Cancer. 2022;10.1002/ijc.33965.

密度	1.084 g/cm3
沸点	403.4ºC at 760 mmHg
分子式	C₁₉H₂₁N
分子量	263.37700
闪点	194.9ºC
精确质量	263.16700
PSA	12.03000
LogP	4.21730
外观性状	白色固体
折射率	1.633
储存条件	2-8°C
分子结构	1、摩尔折射率：86.76 2、摩尔体积（m³/mol）：242.8 3、等张比容（90.2K）：636.9 4、表面张力（dyne/cm）：47.3 5、极化率（10 ^-24cm ³）：34.39
计算化学	1.疏水参数计算参考值（XlogP）:无 2.氢键供体数量:1 3.氢键受体数量:1 4.可旋转化学键数量:3 5.互变异构体数量:无 6.拓扑分子极性表面积12 7.重原子数量:20 8.表面电荷:0 9.复杂度:307 10.同位素原子数量:0 11.确定原子立构中心数量:0 12.不确定原子立构中心数量:0 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:1

毒理学数据:

急性毒性：大鼠口经LD50：502 mg/kg；大鼠静脉LD50：22 mg/kg；

小鼠口经LD50：370 mg/kg；小鼠腹腔LD50：70 mg/kg；小鼠静脉LD50：17 mg/kg；

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HO9800000

CHEMICAL NAME :: 5H-Dibenzo(a,d)cycloheptene-delta(sup 5),gamma-propylamine, 10,11-dihydro-N-methyl-

CAS REGISTRY NUMBER :: 72-69-5

LAST UPDATED :: 199707

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C19-H21-N

MOLECULAR WEIGHT :: 263.41

WISWESSER LINE NOTATION :: L C676 BY&T&J BU3M1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 502 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Behavioral - ataxia Behavioral - muscle contraction or spasticity

REFERENCE :: HEPHD2 Handbook of Experimental Pharmacology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.50- 1978- Volume(issue)/page/year: 55,527,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 22 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Behavioral - ataxia Behavioral - muscle contraction or spasticity

REFERENCE :: HEPHD2 Handbook of Experimental Pharmacology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.50- 1978- Volume(issue)/page/year: 55,527,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 370 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 20,1561,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 70 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 6,338,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 17 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay)

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 17,65,1974 *** REVIEWS *** TOXICOLOGY REVIEW DICPBB Drug Intelligence and Clinical Pharmacy. (POB 42435, Cincinnati, OH 45242) V.3- 1969- Volume(issue)/page/year: 8,690,1974 TOXICOLOGY REVIEW CLCHAU Clinical Chemistry (Winston-Salem, NC). (American Assoc. for Clinical Chemistry, 1725 K St., NW, Washington, DC 20006) V.1- 1955- Volume(issue)/page/year: 19,361,1973 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4842 No. of Facilities: 25 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 2440 (estimated) No. of Female Employees: 1459 (estimated)

海关编码	2921499090

上游产品 9
4444-42-2 74-88-4 50-48-6 16234-88-1
16234-89-2 2939-66-4 115107-86-3 1159-03-1
40443-02-5
下游产品 4
50-48-6 4444-42-2 47132-19-4 47132-16-1

海关编码	2921499090
中文概述	2921499090 其他芳香单胺及衍生物及它们的盐. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%
申报要素	品名, 成分含量, 用途
Summary	2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

1555423-32-9	1521217-40-2
1780614-97-2	1266815-47-7
923-03-5	5658-71-9
1009303-45-0	1782863-35-7
1403468-46-1	1181377-98-9

72-69-5

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

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