210980-68-0

• 常用中文名：去氢辛伐他汀
• 常用英文名：Dehydrosimvastatin
• CAS号：210980-68-0
• 分子式：C₂₅H₃₆O₄
• 分子量：400.551
• 相关类别： 研究领域 其他
• 发布时间：2018-06-25 11:36:33
• 更新时间：2026-07-02 11:09:09
• Anhydrosimvastatin (Impurity C) 是 Simvastatin 的一种杂质。Simvastatin 是 HMG-CoA 还原酶的竞争性抑制剂。

名称

• 中文名: 辛伐他汀杂质C
• 英文名: [(1S,3R,7S,8S,8aR)-3,7-dimethyl-8-[2-[(2R)-6-oxo-2,3-dihydropyran-2-yl]ethyl]-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate
• 中文别名: 脱水辛伐他汀,10 MM DMSO 溶液; 辛伐他汀相关化合物C; 辛伐他汀杂质C 标准品; 脱水辛伐他汀; 脱氢辛伐他汀/辛伐他汀杂质C; 辛伐他汀杂质3(辛伐他汀杂质C); 辛伐他汀杂质C(脱水辛伐他汀); (1S,3R,7S,8S,8-3,7-二甲基-8-(2-((R)-6-氧代-3,6-二氢-2H-吡喃-2-基)乙基)-1,2,3,7,8,8A-六氢萘-1-基 2,2-二甲基丁酸酯; 脱氢辛伐他汀; 2,3-去水辛伐他汀; 辛伐他汀杂质03
• 英文别名: Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,8-8-[2-[(2R)-3,6-dihydro-6-oxo-2H-pyran-2-yl]ethyl]-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-1-naphthalenyl ester; Simvastatin Impurity C/ Simvastatin Related Compound C (2,3-Anhydro Simvastatin/ Dehydro Simvastatin); Simvastatin Impurity C (Anhydro Simvastatin); Simvastatin,Anhydrosimvastatin,inhibit,Inhibitor; Anhydro-simvastatin; 2,2-DiMethylbutanoic Acid (1S,3R,7S,8S,8-8-[2-[(2R)-3,6-Dihydro-6-oxo-2H-pyran -2-yl]ethyl]-1,2,3,7,8,8a-hexahydro-3,7-diMethyl-1-naphthalenyl Ester; Simvastatin Impurity CQ: What is Simvastatin Impurity C Q: What is the CAS Number of Simvastatin Impurity C Q: What is the storage condition of Simvastatin Impurity C Q: What e the applications of Simvastatin Impurity C; Anhydro Simvastatin ((1S,3R,7S,8S,8-3,7-Dimethyl-8-[2-[(2R)-6-oxo-3,6-dihydro-2H-pyran-2-yl]ethy; (1S,3R,7S,8S,8-3,7-Dimethyl-8-[2-[(2R)-6-oxo-3,6-dihydro-2H-pyran-2-yl]ethyl]-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-Dimethylbutanoate (Anhydrosimvastatin); SIMV-IM A; Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,8aR)-8-[2-[(2R)-3,6-dihydro-6-oxo-2H-pyran-2-yl]ethyl]-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-1-naphthalenyl ester; Dehydro Simvastatin; (1S,3R,7S,8S,8-3,7-dimethyl-8-(2-((R)-6-oxo-5,6-dihydro-2H-pyran-2-yl)ethyl)-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate; [(1S,3R,7S,8S,8-3,7-dimethyl-8-[2-[(2R)-6-oxo-2,3-dihydropyran-2-yl]ethyl]-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate; Simvastatin Impurity C（）; (1S,3R,7S,8S,8aR)-3,7-Dimethyl-8-{2-[(2R)-6-oxo-3,6-dihydro-2H-pyran-2-yl]ethyl}-1,2,3,7,8,8a-hexahydro-1-naphthalenyl 2,2-dimethylbutanoate; SiMvastatin IMpurity C; Simvastatin Impurity 3; Anhydro SiMvastatin (SiMvastatin IMpurity C); anhydrosimvastatin; (1S,3R,7S,8S,8-3,7-dimethyl-8-(2-((R)-6-oxo-3,6-dihydro-2H-pyran-2-yl)ethyl)-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate; SiMvastatin IMpurity-C; Anhydrosimvastatin, 10 mM in DMSO; Simvastatin EP Impurity C; Simvastatin Impurity 3（-C）; Simvastatin Impurity 3(Simvastatin Impurity C)

物化性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 536.8±50.0 °C at 760 mmHg
• 分子式: C₂₅H₃₆O₄
• 分子量: 400.551
• 闪点: 265.6±28.5 °C
• 精确质量: 400.261353
• PSA: 52.60000
• LogP: 5.81
• 蒸汽压: 0.0±1.4 mmHg at 25°C
• 折射率: 1.529
• 储存条件: 2-8°C，密封，干燥

生物活性

• 描述: Anhydrosimvastatin (Impurity C) 是 Simvastatin 的一种杂质。Simvastatin 是 HMG-CoA 还原酶的竞争性抑制剂。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. IOANA DRĂGHICI, et al. DEVELOPMENT OF A NEW LC METHOD FOR THE IDENTIFICATION, SEPARATION AND ASSAY OF SIMVASTATIN AND ITS IMPURITIES. FARMACIA, 2013, Vol. 61, 2.

安全

• 危害码 (欧洲): Xi
• 危险品运输编码: NONH for all modes of transport

合成路线

145576-25-6 ~4% 210980-68-0 79902-63-9 121009-77-6

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145576-24-5 850920-00-2 81189-92-6 29138-64-5 151006-15-4 详细

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145576-25-6 ~% 210980-68-0

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145576-24-5 5856-77-9 ~12% 210980-68-0 145576-25-6 详细

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145576-24-5 29138-64-5 ~0% 210980-68-0 850920-00-2 详细

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79902-63-9 ~% 210980-68-0

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