上海阿拉丁生化科技股份有限公司
上海市上海市浦东新区
产品名：依诺沙星
纯度：98.0%
规格：1ml/1g/1g/1g
联系人：阿拉丁

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上海化源世纪贸易有限公司
上海市上海市普陀区
产品名：依诺沙星
纯度：98.0%
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联系人：徐经理

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74011-58-8生产厂家

74011-58-8价格

74011-58-8

74011-58-8结构式

常用中文名：依诺沙星
常用英文名：Enoxacin
CAS号：74011-58-8
分子式：C₁₅H₁₇FN₄O₃
分子量：320.319
相关类别：原料药人工合成抗感染类药喹诺酮类药
发布时间：2018-08-15 08:12:07
更新时间：2026-06-30 19:17:39
Enoxacin是广谱抗菌剂。

化源商城直购

中文名	依诺沙星
英文名	enoxacin
中文别名	依诺沙星/氟啶酸氟啶酸固体依诺沙星依诺沙星溶液, 1000PPM 依诺沙星溶液, 100UG/ML 甲醇溶液依诺沙星-D8 依诺沙星(标准品) 甲醇中依诺沙星溶液标准物质依诺沙星溶液,100PPM 1-乙基-6-氟-4-氧代-7-(哌嗪-1-基)-1,4-二氢-1,8-萘啶-3-羧酸固体依诺沙星/氟啶酸甲醇中依诺沙星葡萄糖依诺沙星葡糖糖酸依诺沙星 1-乙基-6-氟-1,4-二氢-4-氧代-7-(1-哌嗪基)-1,8-亚奈基-3-羧酸依诺沙星,10 MM DMSO 溶液 1-乙基-6-氟-1,4-二氢-4-氧代-7-(-哌嗪基)-1,8-萘啶-3-羧酸依诺沙星/氟啶酸标准品 1-乙基-6-氟-1,4-二氢-4-氧代-7-(1-哌嗪基)-1,8.萘啶-3-羧酸 1-乙基-6-氟-1,4-二氢-4-氧代-7-(1-哌嗪基)-1,8-萘啶-3-羧酸依诺沙星检测标准品依诺沙星溶液, 1000UG/ML 甲醇溶液依诺沙星倍半水合物 Solbio/索莱宝 IE0470
英文别名	MFCD00133308 Gluconate Norfloxacin ENOXACIN C13166950 Enoxacin 1,8-Naphthyridine-3-cboxylic acid, 1,4-dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl) Enoxacin Solution, 100ppm bactidan Enoxacin in Methanol Enoxacin(Penetrex) Enoxacin //BP Penetrex PENETREX (enoxacin) 1,8-naphthyridine-3-cboxylicacid,1,4-dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-pi at-2266 pd107779 Enoxen flumk Enoxacine Enoxacin API 1-Ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid Humk Gyramid Enoxacin, 10 mM in DMSO 1-ETHYL-6-FLUORO-1,4-DIHYDRO-4-OXO-7-[1-PIPERAZINYL]-1,8-NAPHTHYRIDINE-3-CBOXYLIC ACID Enoxacin,1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-cboxylic acid comprecin 1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-cboxylic acid Enoxacin (DMF) 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-c 1-ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid Enofloxacine Enoxacin solution,1000ppm Enoxacin (Patent-No-Supply) 1-ETHYL-6-FLUORO-1,4-DIHYDRO-4-OXO-7-(1-PIPERAZINYL)-1,8-NAPHTHYRIDINE-3-CBOXYLIC ACID (ENOXACIN) ENX Enoxacin 1.5-Hydrate Enoxor Enofloxacin ci919 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid Enoksetin enoram Flumeork Enoxacin (AT-2266) FLUMARK 1,8-Naphthyridine-3-cboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl) Oleanolic Acid Impurity 9 Abenox Enoxacin (Flumk) 1-ethyl-6-fluoro-4-oxo-7-piperazin-4-ium-1-yl-1,8-naphthyridine-3-cboxylate Humark

描述	Enoxacin是广谱抗菌剂。
相关类别	信号通路 >> 抗感染 >> 细菌研究领域 >> 感染
参考文献	[1]. Chin, N.-X. and H.C. Neu, In vitro activity of enoxacin, a quinolone carboxylic acid, compared with those of norfloxacin, new beta-lactams, aminoglycosides, and trimethoprim. Antimicrobial agents and chemotherapy, 1983. 24(5): p. 754-763. [2]. Wijnands, W., T. Vree, and C. Herwaarden, Enoxacin decreases the clearance of theophylline in man. British journal of clinical pharmacology, 1985. 20(6): p. 583-588.

密度	1.4±0.1 g/cm3
沸点	569.9±50.0 °C at 760 mmHg
熔点	220-224ºC
分子式	C₁₅H₁₇FN₄O₃
分子量	320.319
闪点	298.4±30.1 °C
精确质量	320.128479
PSA	87.46000
LogP	0.55
外观性状	灰白色至黄色晶体
蒸汽压	0.0±1.6 mmHg at 25°C
折射率	1.599
储存条件	存放在密封容器内，并放在阴凉，干燥处。2-8 ºC保存。
稳定性	指定条件下稳定，远离氧化物。
分子结构	1、摩尔折射率：78.79 2、摩尔体积（cm³/mol）：230.6 3、等张比容（90.2K）：636.7 4、表面张力（dyne/cm）：58.0 5、极化率（10^-24cm³）：31.23
计算化学	1.疏水参数计算参考值（XlogP）:无 2.氢键供体数量:2 3.氢键受体数量:8 4.可旋转化学键数量:3 5.互变异构体数量:无 6.拓扑分子极性表面积85.8 7.重原子数量:23 8.表面电荷:0 9.复杂度:521 10.同位素原子数量:0 11.确定原子立构中心数量:0 12.不确定原子立构中心数量:0 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:1
更多	1. 性状：白色或浅黄褐色的结晶或结晶性粉末，无臭，味苦。 2. 密度（g/mL,25/4℃）：未确定 3. 相对蒸汽密度（g/mL,空气=1）：未确定 4. 熔点（ºC）：220～224 5. 沸点（ºC,常压）：未确定 6. 沸点（ºC,5.2kPa）：未确定 7. 折射率：未确定 8. 闪点（ºC）：未确定 9. 比旋光度（º）：未确定 10. 自燃点或引燃温度（ºC）：未确定 11. 蒸气压（kPa,25ºC）：未确定 12. 饱和蒸气压（kPa,60ºC）：未确定 13. 燃烧热（KJ/mol）：未确定 14. 临界温度（ºC）：未确定 15. 临界压力（KPa）：未确定 16. 油水（辛醇/水）分配系数的对数值：未确定 17. 爆炸上限（%,V/V）：未确定 18. 爆炸下限（%,V/V）：未确定 19. 溶解性：易溶于冰醋酸，微溶于甲醇，极微溶于氯仿或丙酮，几不溶于乙醇，乙醚或水。

生态学数据:

通常对水是不危害的，若无政府许可，勿将材料排入周围环境。

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QN2800000

CHEMICAL NAME :: 1,8-Naphthyridine-3-carboxylic acid, 1,4-dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-

CAS REGISTRY NUMBER :: 74011-58-8

LAST UPDATED :: 199806

DATA ITEMS CITED :: 15

MOLECULAR FORMULA :: C15-H17-F-N4-O3

MOLECULAR WEIGHT :: 320.36

WISWESSER LINE NOTATION :: T66 BV EN GNJ CVQ E2 IF H- DT6M DNTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Skin and Appendages - hair

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 236 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 327 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >1600 mg/kg

TOXIC EFFECTS :: Behavioral - food intake (animal) Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: >1600 mg/kg

TOXIC EFFECTS :: Behavioral - food intake (animal) Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 90 gm/kg/30D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in bladder weight Blood - changes in leukocyte (WBC) count Nutritional and Gross Metabolic - changes in calcium

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 273 gm/kg/26W-I

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - changes in testicular weight

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1680 mg/kg/4W-I

TOXIC EFFECTS :: Skin and Appendages - dermatitis, other (after systemic exposure) Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 91 gm/kg

SEX/DURATION :: male 13 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 11 gm/kg

SEX/DURATION :: female 7-17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 200 ng/plate

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 281,207,1992

危害码 (欧洲)	Xi
风险声明 (欧洲)	36/37/38
安全声明 (欧洲)	26-36/37
WGK德国	2
RTECS号	QN2800000
海关编码	29335995

上游产品 7
110-85-0 114171-68-5 23651-62-9 82671-02-1
96568-25-1 108108-37-8 114190-30-6
下游产品 2
87939-13-7 74274-68-3

方法1：以2，6-二羟基-5-氟烟酰胺为原料，经氯化、酯化、与乙酰哌嗪缩合、与3-乙胺基丙酸乙酯缩合、环化、脱氢、水解得产品。该路线条件温和，路线较短，但需特殊试剂四氯苯醌。国内目前主要采用该法。

方法2：另一条路线是以2，6-二氯-3-硝基吡啶为原料，经与乙氧羰基哌嗪缩合后，再经氨解、乙酰化、还原、重氮化、氟化、水解、与EMME缩合、环合乙基化、水解得产品。该法氟化反应不易控制、环化需高温，工艺条件苛刻。

海关编码	29335995

1351616-13-1	1351611-79-4
1351599-95-5	1351649-63-2
1351602-08-8	1351645-83-4
1351598-09-8	1351602-15-7
1351582-75-6	1351608-75-7

74011-58-8

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

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