120410-24-4

• 常用中文名：比阿培南
• 常用英文名：Biapenem
• CAS号：120410-24-4
• 分子式：C₁₅H₁₈N₄O₄S
• 分子量：350.393
• 相关类别： 原料药 人工合成抗感染类药 抗真菌类药
• 发布时间：2018-05-11 08:00:00
• 更新时间：2026-06-30 17:17:14
• Biapenem是不经肠道的广谱碳青霉烯抗生素。

名称

• 中文名: 比阿培南
• 英文名: biapenem
• 中文别名: 比阿培南杂质; 比阿培南 BIAPENEM; 比阿培南(标准品); 比阿培南粗品; 比阿培南检测标准品; 比阿培南无菌粉; (4R,5S,6S)-3-((6,7-二氢-5H-吡唑并[1,2-A][1,2,4]三唑-4-鎓-6-基)硫基)-6-((R)-1-羟乙基)-4-甲基-7-氧代-1-氮杂双环[3.2.0]庚烷-2-烯-2-羧酸内盐; 保护比阿培南; 比阿陪南; 比亚培南; 比可培南; 比阿培南比亚培南; 6-[[(4R,5S,6S)-2-羧基-6-((1R)-1-羟乙基)-4-甲基-7-氧代-1-氮杂双环[3.2.0]庚-2-烯-3-基]硫]-6,7-双氢-5H-哌唑酮[1,2-a][1,2,4]三氮杂-4-内盐; BIAPENEM 比阿培南; 11比阿培南; 阿比培南
• 英文别名: Biapenem (JAN/USAN); 6-{[(4R,5S,6S)-2-cboxylato-6-[(1R)-1-hydroxyethyl]-4-Methyl-7-oxo-1-azabicyclo[3.2.0]ht-2-en-3-yl]sulfanyl}-5H,6H,7H-2; LJC-10627; Biapenem for Injection; BiapenemQ: What is Biapenem Q: What is the CAS Number of Biapenem Q: What is the storage condition of Biapenem Q: What e the applications of Biapenem; Biapenem, >=; l^{5},2,4]triazol-4-yliuM; Biapenem Impurity 13; l^{5},8000000-pyrazolo[1,2-a][1; L-627; LJC; Biapenem [USAN:INN]; Biapenem Powder Standd; (4R,5S,6S)-3-(6,7-Dihydro-5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium-6-ylsulfanyl)-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate; [4R-[4a,5b,6b(R*)]]-6-[[2-Carboxy-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl]thio]-6,7-dihydro-5 H-pyrazolo[1,2-a][1,2,4]triazol-4-ium inner salt; Biapenem (GMP); Biapenem //BP; Biapenem AKSci M048; omegacin; MFCD00864863; BiapeneM; Biapenem Powder; LJ C10,627; Biapenern; (4R,5S,6S)-3-(6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium-6-ylthio)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]ht-2-ene-2-cboxylate; 6-(7-oxo-1-azabicyclo[3.2.0]ht-2-en-6-yl)-1-azabicyclo[3.2.0]ht-2-en-7-one; 6-[[(4R,5S,6S)-2-Cboxylato-6β-[(R)-1-hydroxyethyl]-4α-methyl-7-oxo-1-azabicyclo[3.2.0]ht-2-en-3-yl]thio]-6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium; 6-[[(4r,5s,6s)-2-cboxy-6-[(1r)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]ht-2-en-3-yl]thio]-6,7-dihydro-5h-pyrazolo[1,2-a][1,2,4]triazol-4-ium inner salt; 6-[[(4R,5β)-2-Cboxylato-4α-methyl-6β-[(R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]ht-2-en-3-yl]thio]-6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium; protected biapenum; Crude; 6-[[(4R,5S,6S)-2-Cboxylato-6β-[(1R)-1-hydroxyethyl]-4α-Methyl-7-oxo-1-azabicyclo[3.2.0]he; ade; OMegacin; EINECS 204-352-8; 5H-Pyrazolo[1,2-a][1,2,4]triazol-4-ium, 6-[[(4R,5S,6S)-2-carboxy-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl]thio]-6,7-dihydro-, inner salt; BiapeneM Crude; protected biapenem; LJ C10627; Biapenem Biapenem; (4R,5S,6S)-3-((6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium-6-yl)thio)-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]ht-2-ene-2-cboxylate; (155-9) biapenem; L-627; 6-[[(4R,5S,6S)-2-Cboxylato-6β-[(1R)-1-hydroxyethyl]-4α-methyl-7-oxo-1-azabicyclo[3.2.0]ht-2-en-3-yl]thio]-6,7-dihydro-5H-pyrazolo[1,2-a]-s-triazol-4-ium; 5H-Pyrazolo[1,2-a][1,2,4]triazol-4-ium, 6-[[(4R,5S,6S)-2-cboxy-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]ht-2-en-3-yl]thio]-6,7-dihydro-, inner salt

物化性质

• 熔点: 265-271°C (dec.)
• 分子式: C₁₅H₁₈N₄O₄S
• 分子量: 350.393
• 精确质量: 350.104889
• PSA: 127.67000
• 外观性状: 白色至淡黄色粉末
• 折射率: 1.651
• 储存条件: -20?C Freezer

生物活性

• 描述: Biapenem是不经肠道的广谱碳青霉烯抗生素。
• 相关类别:
  信号通路 >> 抗感染 >> 细菌
  研究领域 >> 感染
• 参考文献:

  [1]. Perry, C.M. and T. Ibbotson, Biapenem. Drugs, 2002. 62(15): p. 2221-34; discussion 2235.

  [2]. Kasahara, S., et al., [Clinical effects of biapenem on febrile neutropenia in patients with hematological malignancy]. Jpn J Antibiot, 2008. 61(3): p. 115-21.

安全

• 危险品运输编码: NONH for all modes of transport

合成路线

93711-81-0 ~% 120410-24-4

文献：Journal of Organic Chemistry, , vol. 57, # 15 p. 4243 - 4249

104873-15-6 ~% 120410-24-4

文献：Journal of Organic Chemistry, , vol. 57, # 15 p. 4243 - 4249

120764-68-3 ~% 120410-24-4

文献：Journal of Organic Chemistry, , vol. 57, # 15 p. 4243 - 4249

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